-

Habtemariam, Solomon (2012) Identification of the antidiabetic and antihyperlipidemic principles of Cassia auriculata. Planta Medica, 78 (11). ISSN 0032-0943 (Print), 1439-0221 (Online) (doi:https://doi.org/10.1055/s-0032-1320409)

Acetylcholine, Alzheimer’s disease, docking, enzyme inhibition, marine natural products

Khan, Inamullah, Samad, Abdus, Khan, Amir Zada, Habtemariam, Solomon, Badshah, Amir, Abdullah, Syed Muhammad, Ullah, Naseem, Khan, Abuzar and Zia-Ul-Haq, Muhammad (2013) Molecular interactions of 4-acetoxy-plakinamine B with peripheral anionic and catalytic subsites of the aromatic gorge of acetylcholinesterase: Computational and structural insights. Pharmaceutical Biology, 51 (6). pp. 722-727. ISSN 1388-0209 (Print), 1744-5116 (Online) (doi:https://doi.org/10.3109/13880209.2013.764329)

Acetylcholinesterase, Alzheimer's disease, Berberidaceae, Berberine, Berberis darwinii

Habtemariam, Solomon (2011) The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy. Natural Product Communications, 6 (8). pp. 1089-1090. ISSN 1934-578X (Print), 1555-9475 (Online)

Age-related eye diseases; antioxidant; carotenoid; lens; nutraceuticals; oxidative stress

Manaye, Azadeh, Abdollahi, Mohammad, Thiagarajan, Raman, Nabavi, Seyed Fazel, Habtemariam, Solomon, Daglia, Maria and Nabavi, Seyed Mohammad (2015) Lutein and Cataract: from bench to bedside. Critical Reviews in Biotechnology, 36 (5). pp. 829-839. ISSN 0738-8551 (Print), 1549-7801 (Online) (doi:https://doi.org/10.3109/07388551.2015.1049510)

Age-related macular degeneration; Cataract; Ocular problems; Oxidative stress; Zeaxanthin

Manikandan, Ramar, Thiagarajan, Raman, Goutham, Ganesh, Arumugam, Munusamy, Beulaja, Manikandan, Rastrelli, Luca, Skalicka-Woźniak, Krystyna, Habtemariam, Solomon, Orhan, Ilkay Erdogan, Nabavi, Seyed Fazel and Nabavi, Seyed Mohammad (2015) Zeaxanthin and ocular health, from bench to bedside. Fitoterapia, 109. pp. 58-66. ISSN 1873-6971 (doi:https://doi.org/10.1016/j.fitote.2015.12.009)

Alzheimer’s disease; amyloid beta; caffeic acid; danshensu; dementia; neurodegeneration; rosmarinic acid; salvianolic acids; tau protein

Habtemariam, Solomon (2018) Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer’s and vascular dementia drugs. International Journal of Molecular Sciences, 19 (2):458. p. 458. ISSN 1661-6596 (Print), 1422-0067 (Online) (doi:https://doi.org/10.3390/ijms19020458)

Anthocyanins, Antioxidant, Berry, Diabetes, Diabetic retinopathy

Nabavi, S. F., Habtemariam, Solomon, Daglia, M., Shafighi, N., Barber, A. J. and Nabavi, S.M. (2015) Anthocyanins as a potential therapy for diabetic retinopathy. Current Medicinal Chemistry, 22 (1). pp. 51-58. ISSN 0929-8673 (Print), 1875-533X (Online) (doi:https://doi.org/10.2174/0929867321666140815123852#sthash.Fo34pIn9.dpuf)

Antioxidant enzymes, Human cells, Methyl 3-O-methyl gallate, MicroRNA, miR-17-3p expression level

Curti, V., Capelli, E., Nabavi, S. F., Habtemariam, Solomon, Nabavi, S. M. and Daglia, M. (2014) Modulation of human miR-17-3p expression by methyl 3-O-methyl gallate as explanation of its in vivo protective activities. Molecular Nutrition & Food Research, 58 (9). pp. 1776-1784. ISSN 1613-4125 (Print), 1613-4133 (Online) (doi:https://doi.org/10.1002/mnfr.201400007)

Antioxidant enzymes, flavonoid, neural tissues, reduced glutathione

Nabavi, S.F., Nabavi, S.M., Latifi, A.M., Mirzaei, M., Habtemariam, Solomon and Moghaddam, A.H. (2012) Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain. Pharmaceutical Biology, 50 (11). pp. 1380-1383. ISSN 1388-0209 (Print), 1744-5116 (Online) (doi:https://doi.org/10.3109/13880209.2012.675341)

Antioxidant, Anti-inflammatory, Fisetin, Neurodegeneration, Neuroprotective, Mental diseases.

Nabavi, Seyed Fazel, Braidy, Nady, Habtemariam, Solomon, Sureda, Antoni, Manayi, Azadeh and Nabavi, Seyed Mohammad (2016) Neuroprotective effects of fisetin in Alzheimer’s and Parkinson's Diseases: From chemistry to medicine. Current Topics in Medicinal Chemistry, 16 (17). pp. 1910-1915. ISSN 1568-0266 (Print), 1873-4294 (Online) (doi:https://doi.org/10.2174/1568026616666160204121725)

Antioxidant, Catalase, Haemolysates, Reduced glutathione, Superoxide dismutase

Nabavi, Seyed Fazel, Habtemariam, Solomon, Sureda, Antoni, Moghaddam, Akbar Hajizadeh, Daglia, Maria and Nabavi, Seyed Mohammad (2013) In vivo protective effects of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in erythrocytes. Archives of Industrial Hygiene and Toxicology, 64 (4). pp. 563-569. ISSN 0004-1254 (doi:https://doi.org/10.2478/10004-1254-64-2013-2353)

Antioxidant, Curcumin, Hepatic disorders, Nuclear factor-kB, Turmeric

Nabavi, Seyed Fazel, Daglia, Maria, Habtemariam, Solomon, Nabavi, Seyed Mohammad and Moghaddam, Akbar Hajizadeh (2014) Curcumin and liver health: From chemistry to medicine. Comprehensive Reviews in Food Science and Food Safety, 12 (1). pp. 62-67. ISSN 1541-4337 (Print), 1541-4337 (Online) (doi:https://doi.org/10.1111/1541-4337.12047)

Antiviral, HSV, Tanacetum, Tansy, Rhizome, Spiroketals

Álvarez, Ángel L., Habtemariam, Solomon, Moneim, Ahmed, Melón, Santiago, Dalton, Kevin and Parra, Francisco (2015) A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells. Antiviral Research, 119. pp. 8-18. ISSN 0166-3542 (Print), 1872-9096 (Online) (doi:https://doi.org/10.1016/j.antiviral.2015.04.004)

Artemisia roxburghiana; PTP1B; docking; triterpenes; ursolic acid

Shah, Muhammad Raza, Ishtiaq, , Hizbullah, Syed Muhammad, Habtemariam, Solomon, Zarrelli, Armando, Muhammad, Akhtar, Collina, Simona and Khan, Inamullah (2015) Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana. Journal of Enzyme Inhibition and Medicinal Chemistty, 31 (4). pp. 563-567. ISSN 1475-6366 (Print), 1475-6374 (Online) (doi:https://doi.org/10.3109/14756366.2015.1047358)

Berberine; Acetylcholinesterase; Antioxidants; Phenethylamines; Alzheimer’s disease

Roselli, Mariagrazia, Cavalluzzi, Maria Maddalena, Bruno, Claudio, Lovece, Angelo, Carocci, Alessia, Franchini, Carlo, Habtemariam, Solomon and Lentini, Giovanni (2016) Synthesis and evaluation of berberine derivatives and analogues as potential anti-acetylcholinesterase and antioxidant agents. Phytochemistry Letters, 18. pp. 150-156. ISSN 1874-3900 (Print), 1876-7486 (Online) (doi:https://doi.org/10.1016/j.phytol.2016.10.005)

Berberine; Inflammatory bowel disease; Anti-inflammatory mechanisms; Antinociceptive; Epithelial barrier protection; Anti-diarrhoeal

Habtemariam, Solomon (2016) Berberine and inflammatory bowel disease: A concise review. Pharmacological Research, 113 (Part A). pp. 592-599. ISSN 1043-6618 (Print), 1096-1186 (Online) (doi:https://doi.org/10.1016/j.phrs.2016.09.041)

Bergenia cordifolia, Saxifragaceae, antioxidant, anti-α-glucosidase, anticholinesterase, (+)-catechin gallates, 1,2,4,6-tetra-O-galloyl-β- d-glucopyranoside

Roselli, Mariagrazia, Lentini, Giovanni and Habtemariam, Solomon (2011) Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia. Phytotherapy Research, 26 (6). pp. 908-914. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.3655)

Blood glucose control; Type-2 diabetes; Aloe vera supplements

Habtemariam, Solomon (2017) Could we really use aloe vera food supplements to treat diabetes? Quality control issues. Evidence-Based Complementary and Alternative Medicine. ISSN 1741-427X (Print), 1741-4288 (Online) (doi:https://doi.org/10.1155/2017/4856412)

Bursera simaruba, antiviral, HSV-1, HSV-2, pentacyclic triterpenoids

Álvarez, Ángel L., Habtemariam, Solomon and Parra, Francisco (2015) Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication. Natural Product Research, 29 (24). pp. 2322-2327. ISSN 1478-6419 (Print), 1478-6427 (Online) (doi:https://doi.org/10.1080/14786419.2015.1007456)

Caesalpiniaceae, diabetes, kaempferol, kaempferol 3-O-gentiobioside

Varghese, George Kadakasseril, Bose, Lekshmi Vijaya and Habtemariam, Solomon (2013) Antidiabetic components of Cassia alata leaves: Identification through a-glucosidase inhibition studies. Pharmaceutical Biology, 51 (3). pp. 345-349. ISSN 1388-0209 (Print), 1744-5116 (Online) (doi:https://doi.org/10.3109/13880209.2012.729066)

Capparis spinosa; Caper; Medicinal plant; Polyphenolic compounds

Nabavi, Seyed Fazel, Maggi, Filippo, Daglia, Maria, Habtemariam, Solomon, Rastrelli, Luca and Nabavi, Seyed Mohammad (2016) Review: Pharmacological effects of Capparis spinosa L. Phytotherapy Research, 30 (11). pp. 1733-1744. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.5684)

Cardiac stress, Fluoride in rats, Lipid peroxidation, Methyl-3-O-methyl gallate Oxidative stress in rats

Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon, Moghaddam, Akbar Moghaddam, Daglia, Maria and Abolhasani, Fatemeh (2012) Protective effect of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in rat’s cardiac tissues. Fluoride, 45 (3). pp. 290-292. ISSN 0015-4725 (Print), 2253-4083 (Online)

Cassia auriculata, Caesalpiniaceae, Antilipase, Kaemperol-3-O-rutinoside rutin, Quercetin, luteolin, Kaempferol

Habtemariam, Solomon (2013) Antihyperlipidemic components of Cassia auriculata aerial parts: Identification through in vitro studies. Phytotherapy Research, 27 (1). pp. 152-155. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.4711)

Cassine transvaalensis, antioxidant, DPPH radicals, 4’-O-methylepigallocatechin, epicatechin

Motlhanka, D.M.T, Habtemariam, S. and Houghton, P. (2008) Free radical scavenging activity of crude extracts and 4´-O-methylepigallocatechin isolated from roots of Cassine transvaalensis Burtt-Davy from Botswana. African Journal of Biomedical Research, 11 (1). pp. 55-63. ISSN 1119-5096

Citrus limonoids; Tetranortriterpenoids; Lead compound; Structure-activity relationships; Ligand efficiency metrics; Developability; Antimicrobial; Anticancer; antioxidant; Antiinflammatory; Insecticidal; Antidiabetic

Gualdani, Roberta, Cavalluzzi, Maria, Lentini, Giovanni and Habtemariam, Solomon (2016) The chemistry and pharmacology of citrus limonoids. Molecules, 21 (11):1530. pp. 1-39. ISSN 1420-3049 (Print), 1420-3049 (Online) (doi:https://doi.org/10.3390/molecules21111530)

Combretum, phytochemistry, pharmacology, terpenoids, polyphenolic compounds, antibacterial activity, antifungal activity

Dawe, Amadou, Pierre, Saotoing, Tsala, David Emery and Habtemariam, Solomon (2013) Phytochemical Constituents of Combretum Loefl. (Combretaceae). Pharmaceutical Crops, 4. pp. 38-59. ISSN 2210-2906 (doi:https://doi.org/10.2174/2210290601304010038)

Commiphora glandulosa resins, antibacterial activity, novel pentacyclic triterpene, Botswana medicinal plants, antibacterial activity

Motlhanka, Daniel, Houghton, Peter, Miljkovic-Brake, Ana and Habtemariam, Solomon (2010) A novel pentacyclic triterpene glycoside from a resin of Commiphora glandulosa from Botswana. African Journal of Pharmacy and Pharmacology, 4 (8). pp. 549-554. ISSN 1996 0816

Depression; Gallic acid; Ischemia; Stroke

Nabavi, Seyed Fazel, Habtemariam, Solomon, Di Lorenzo, Arianna, Sureda, Antoni, Khanjani, Sedigheh, Nabavi, Seyed Mohammad and Daglia, Maria (2016) Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system. Nutrients, 8 (5). p. 248. ISSN 2072-6643 (Online) (doi:https://doi.org/10.3390/nu8050248)

Ebola; plant medicines; new antiviral agents

Habtemariam, Solomon and Lentini, Giovanni (2015) Did Ebola survivors use plant medicines, and if so, which ones? Phytotherapy Research, 29 (4). p. 632. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.5279)

Embelia ribes, Myrsinaceae, embelin, antidepressant, imipramine, tail suspension test, forced swimming test

Gupta, Gaurav, Kazmi, Imran, Afzal, Muhammad, Upadhyay, Gaurav, Singh, Rajnish and Habtemariam, Solomon (2013) Antidepressant-like activity of Embelin isolated from Embelia ribes. Phytopharmacology, 4 (1). pp. 87-95. ISSN 2046-1194

Emesis, anti-emetics, natural products, anti-emetic experimental models, drug development

Ahmed, Salman, Hasan, Muhammad Mohtasheemul, Ahmed, Syed Waseemuddin, Mahmood, Zafar Alam, Azhar, Iqbal and Habtemariam, Solomon (2013) Anti-emetic effects of bioactive natural products. Phytopharmacology, 4 (2). pp. 390-433. ISSN 2046-1194

Epilobium parviflorum Schreb, benign prostatic hyperplasia, BPH

Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, S., Milligan, S., Kalita, C.J., Purohit, A. and Kéry, Á. (2007) Epilobium parviflorum Schreb. - in vitro study of biological action. Planta Medica, 73 (9). P454. ISSN 0032-0943 (doi:https://doi.org/10.1055/s-2007-987234)

Epilobium parviflorum, BPH, DPPH, TBA, fibroblast, COX-enzyme

Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, Solomon and Kéry, Á. (2009) Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. Phytotherapy Research, 23 (5). pp. 719-724. ISSN 0951418X (doi:https://doi.org/10.1002/ptr.2725)

Erythrocyte, Fluoride, Methyl-3-O-methyl gallate, Oxidative damage

Nabavi, S.M., Habtemariam, Solomon, Nabavi, S.F., Moghaddam, A.H. and Latifi, A.M. (2013) Prophylactic effect of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in rat’s erythrocytes in vivo. Journal of Pharmacy and Pharmacology, 65 (6). pp. 868-873. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12048)

European plants, drug leads, Berberis darwinii; Bergenia cordifolia

Habtemariam, Solomon (2013) The hidden treasure in Europe’s garden plants: Case examples; Berberis darwinni and Bergenia cordifolia. Medicinal & Aromatic Plants, 2 (4):1000130. ISSN 2167-0412 (doi:https://doi.org/10.4172/2167-0412.1000130)

Ferula, Disorders, Antioxidant mechanisms, Pharmacology

Nabavi, Seyed Fazel, Habtemariam, Solomon, Sureda, Antoni and Nabavi, Seyed Mohammad (2012) Ferula gummosa Boiss as a rich source of natural antioxidants with numerous therapeutic uses - A short review. In: Capasso, Anna, (ed.) Medicinal Plants as Antioxidant Agents: Understanding Their Mechanism of Action and Therapeutic Efficacy. Research Signpost, Kerala, India, pp. 15-26. ISBN 9788130805092

Gallic acid, Oxidative stress, Sodium fluoride, Nephrotoxicity

Nabavi, Seyed Mohammad, Habtemariam, Solomon, Nabavi, Seyed Fazel, Sureda, Antoni, Daglia, Maria, Moghaddam, Akbar Hajizadeh and Amani, Mohammad Ali (2012) Protective effect of gallic acid against sodium fluoride-induced oxidative stress in rat’s kidney. Molecular and Cellular Biochemistry, 372 (1-2). pp. 233-239. ISSN 0300-8177 (Print), 1573-4919 (Online) (doi:https://doi.org/10.1007/s11010-012-1464-y)

Gallic acid, methyl-3-O-methyl gallate, prostate cancer, stem cells

Civenni, G., Iodice, M. G., Nabavi, S. F., Habtemariam, S., Nabavi, S. M., Catapano, C. V. and Daglia, M. (2015) Gallic acid and methyl-3-O-methyl gallate: a comparative study on their effects on prostate cancer stem cells. RSC Advances, 5 (78). pp. 63800-63806. ISSN 2046-2069 (Online) (doi:https://doi.org/10.1039/C5RA07988H)

Ginsenoside Rd, Panax ginseng, signal transduction

Nabavi, Seyed Fazel, Sureda, Antoni, Habtemariam, Solomon and Nabavi, Seyed Mohammad (2015) Ginsenoside Rd and ischemic stroke; a short review of literatures. Journal of Ginseng Research, 39 (4). pp. 299-303. ISSN 1226-8453 (doi:https://doi.org/10.1016/j.jgr.2015.02.002)

Kniphofia foliosa (Asphodelaceae), Knipholone, Knipholone anthrone, cytotoxicity, apoptosis, necrosis

Habtemariam, S. (2010) Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia, 81 (8). pp. 1013-1019. ISSN 0367-326X (doi:https://doi.org/10.1016/j.fitote.2010.06.021)

Medicinal plants, ethnobotany, urolithiasis, kidney stone

Varghese, George, John, Diana and Habtemariam, Solomon (2013) Medicinal plants for kidney Stone: a monograph. LAP Lambert Academic Publishing. ISBN 978-3-659-49778-0

Metabolism; Capillary electrophoresis; Mass spectrometry; Metabolism; Capillary electrophoresis; Mass spectrometry; Glutathione conjugation

Lentini, Giovanni and Habtemariam, Solomon (2014) Microchip capillary electrophoresis–electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: An intriguing case. Journal of Chromatography A, 1327. p. 160. ISSN 0021-9673 (doi:https://doi.org/10.1016/j.chroma.2013.12.068)

Mexiletine; Antiarrhythmics; P-glycoprotein; Inotropism; MW-assisted synthesis

Roselli, Mariagrazia, Carocci, Alessia, Budriesi, Roberta, Micucci, Matteo, Toma, Maddalena, Di Cesare Mannelli, Lorenzo, Lovece, Angelo, Catalano, Alessia, Cavalluzzi, Maria Maddalena, Bruno, Claudio, De Palma, Annalisa, Contino, Marialessandra, Perrone, Maria Grazia, Colabufo, Nicola Antonio, Chiarini, Alberto, Franchini, Carlo, Ghelardini, Carla, Habtemariam, Solomon and Lentini, Giovanni (2016) Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. European Journal of Medicinal Chemistry, 121. pp. 300-307. ISSN 0223-5234 (doi:https://doi.org/10.1016/j.ejmech.2016.05.046)

Monocytes, macrophages, inflammation, herbal drugs, proinflammatory cytokines, TNF-α, IL-1β, IL-6, IL-8, IL-10, HMGB1

Habtemariam, Solomon (2013) Targeting the production of monocytes/macrophages-derived cytokines by anti-inflammatory herbal drugs. Phytopharmacology, 4 (1). pp. 131-148. ISSN 2046-1194

Moringa stenopetala, Diabetes, Oxidative damage, Pancreatic-cells, Rutin, Neochlorogenic acid.

Habtemariam, Solomon (2015) Investigation into the antioxidant and antidiabetic potential of Moringa stenopetala: Identification of the active principles. Natural Product Communications, 10 (3). pp. 475-478. ISSN 1934-578X (Print), 1555-9475 (Online)

Moringa stenopetala; Moringaceae; Seeds; Glucomoringin isothiocyanate; Moringin; Cancer; HPLC; Combiflash chromatography

Habtemariam, Solomon (2017) Methodology for rapid isolation of Moringin: Potential anticancer compound from the seeds of Moringa stenopetala. Pharmaceutica Analytica Acta, 8 (8):1000558. ISSN 2153-2435 (Online) (doi:https://doi.org/10.4172/2153-2435.1000558)

NA

Lentini, Giovanni and Habtemariam, Solomon (2015) Plotting intersections. Nature Methods (Correspondence), 12 (281). ISSN 1548-7091 (Print), 1548-7105 (Online) (doi:https://doi.org/10.1038/nmeth.3328)

Nabavi, S.M., Habtemariam, Solomon, Daglia, M and Nabavi, S.F. (2015) Apigenin and Breast Cancers: from Chemistry to Medicine. Anticancer Agents in Medicinal Chemistry, 15 (6). 728 -735. ISSN 1871-5206 (doi:https://doi.org/10.2174/1871520615666150304120643#sthash.9UczvT47.dpuf)

Natural products, secondary metabolites, wound healing, inflammation, proliferation, remodeling

Tsala, David Emery, Amadou, Dawe and Habtemariam, Solomon (2013) Natural wound healing and bioactive natural products. Phytopharmacology, 4 (3). pp. 532-560. ISSN 2046-1194

Neurodegenerative diseases; mTOR; omega-3; Docosahexaenoic acid; Eicosapentaenoic acid

Shirooie, Samira, Nabavi, Seyed Fazel, Dehpour, Ahmad R., Belwal, Tarun, Habtemariam, Solomon, Argüelles, Sandro, Sureda, Antoni, Daglia, Maria, Tomczyk, Michał, Sobarzo-Sanchez, Eduardo, Xu, Suowen and Nabavi, Seyed Mohammad (2018) Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration? Pharmacological Research, 135. pp. 37-48. ISSN 1043-6618 (Print), 1096-1186 (Online) (doi:https://doi.org/10.1016/j.phrs.2018.07.004)

Neurotrophins, Traumatic brain injury and BDNF, Neurodegenerative diseases

Habtemariam, Solomon (2018) The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs. Neural Regeneration Research, 13 (6). pp. 983-984. ISSN 1673-5374 (Print), 1876-7958 (Online) (doi:https://doi.org/10.4103/1673-5374.233438)

Not applicable

Habtemariam, Solomon (2017) The African and Arabian Moringa Species: Chemistry, Bioactivity and Therapeutic Applications. Elsevier, Oxford/Amsterdam. ISBN 978-0-08-102286-3

Obesity, pancreatic lipase, α-glucosidase, eriodictyol, sigmoidin A, prenylated flavonoids, Erythrina abyssinica, Fabaceae Read More: http://informahealthcare.com/doi/abs/10.3109/13880209.2012.688838

Habtemariam, Solomon (2012) The anti-obesity potential of sigmoidin A. Pharmaceutical Biology, 50 (12). pp. 1519-1522. ISSN 1388-0209 (Print), 1744-5116 (Online) (doi:https://doi.org/10.3109/13880209.2012.688838)

Paullinia pinnata, Sapindaceae, Novel triterpene, Lupine

Jackson, N., Annan, K., Mensah, A.Y., Ekuadzi, E, Mensah, M.L.K. and Habtemariam, Solomon (2015) A novel triterpene from the roots of Paullinia pinnata: 6a-(3’-methoxy-4’-hydroxybenzoyl)-lup-20(29)-ene-3-one. Natural Product Communications, 10 (4). pp. 563-564. ISSN 1934-578X (Print), 1555-9475 (Online)

Peltiphyllum peltatum, Saxifragaceae, Antioxidant, α-glucosidase, 11-O-galloylbergenin, Gallates, Catechins

Habtemariam, Solomon and Cowley, Raymond (2012) Antioxidant and anti-α-glucosidase compounds from the rhizome of Peltiphyllum peltatum (Torr.) Engl. Phytotherapy Research, 26 (11). pp. 1656-1660. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.4626)

Peltiphyllum peltatum, Gallic acid, Fluoride toxicity, Antioxidant, Oxidative stress

Nabavi, S.F., Habtemariam, Solomon, Jafar, M., Sureda, A. and Nabavi, S.M. (2012) Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bulletin of Environmental Contamination and Toxicology, 89 (1). pp. 73-77. ISSN 0007-4861 (Print), 1432-0800 (Online) (doi:https://doi.org/10.1007/s00128-012-0645-4)

Peltiphyllum peltatum, saxifragaceae, antioxidant, radical scavenging, reducing power, phenol content, Cytoprotection, DPPH, hydroxyl radical

Habtemariam, Solomon and Jackson, Caroline (2007) Antioxidant and cytoprotective activity of leaves of Peltiphyllum peltatum (Torr.) Engl. Food Chemistry, 105 (2). p. 498. ISSN 0308-8146 (doi:https://doi.org/10.1016/j.foodchem.2007.03.073)

Premna serattifolia, Verbenaceae, antioxidant, root wood, acteoside, verbacoside

Bose, Lekshmi V., Varghese, George K. and Habtemariam, Solomon (2013) Identification of acteoside as the active antioxidant principle of Premna serratifolia root wood tissues. Phytopharmacology, 4 (2). pp. 228-236. ISSN 2046-1194

Premna serratifolia, Verbenaceae, Novel diterpene skeleton, Cytotoxic, Antioxidant

Habtemariam, Solomon and Varghese, G.K. (2015) A Novel Diterpene Skeleton: Identification of a highly aromatic, cytotoxic and antioxidant 5-methyl-10-demethyl-abietane-type diterpene from Premna serratifolia. Phytotherapy Research, 29 (1). pp. 80-85. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.5229)

Rutin, Quercetin-3-O-rutinoside, Alzheimer’s disease, Neurodegeneration, Amyloid-beta.

Habtemariam, Solomon (2016) Rutin as a natural therapy for Alzheimer’s disease: Insights into its mechanisms of action. Current Medicinal Chemistry, 23 (9). pp. 860-873. ISSN 0929-8673 (doi:https://doi.org/10.2174/0929867323666160217124333)

Rutin, diabetes, Anti-inflammatory, Antioxidant, Organ protection, Multifunctional compound

Habtemariam, Solomon and Lentini, Giovanni (2015) The therapeutic potential of rutin for diabetes: an update. Mini-Reviews in Medicinal Chemistry, 15 (7). pp. 524-528. ISSN 1389-5575 (Print), 1875-5607 (Online) (doi:https://doi.org/10.2174/138955751507150424103721)

Senna tora, Cassia tora, Cassiatorin, Aurantio-obtusin, Insecticidal, Ovipositor deterrent, Antifeedant, Cowpea weevil

Mbatchou, Valentine Chi, Dickson, Rita Akosua, Amponsah, Isaac Kingsley, Mensah, Abraham Yeboah and Habtemariam, Solomon (2018) Protection effect of the anthraquinones, cassiatorin and aurantio-obtusin from seeds of Senna tora against cowpea weevil attack. Asian Pacific Journal of Tropical Biomedicine. ISSN 2221-1691 (Print), 2588-9222 (Online) (doi:https://doi.org/10.4103/2221-1691.225620)

Sideroxylon foetidissimum subsp. gaumeri, Sapotaceae, Yucatan peninsula, endemic, triterpenoid saponins, cytotoxic activity, medicinal plants, HPLC, NMR

Sánchez-Medina, Alberto, Stevenson, Philip C. ORCID: 0000-0002-0736-3619 , Habtemariam, Solomon, Peña-Rodríguez, Luis M., Corcoran, Olivia, Mallet, Anthony I. and Veitch, Nigel C. (2009) Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri. Phytochemistry, 70 (6). pp. 765-772. ISSN 0031-9422 (doi:https://doi.org/10.1016/j.phytochem.2009.03.014)

Sideroxylon foetidissimum, saponins

Sanchez Medina, A., Stevenson, P.C. ORCID: 0000-0002-0736-3619 , Habtemariam, S., Peña-Rodríguez, L.M., Corcoran, O., Mallet, T.A. and Veitch, N.C. (2008) Triterpenoid saponins from the cytotoxic root extract of Sideroxylon foetidissimum, an endemic Yucatecan medicinal plant. Planta Medica, 74 (9). SL13-SL13. ISSN 0032-0943 (doi:https://doi.org/10.1055/s-0028-1083893)

Smeathxanthone A; Wound; Tensile strength; Antihyperglycemia.

Tsala, David Emery, Lannang, Alain Meli, Dimo, Theophile, Habtemariam, Solomon, Ekanga, Jean Arnaud, Guemmogne, Blandine Mbougen and Sewald, Norbert (2016) Antidiabetic and wound healing effects of smeathxanthone A. Recent Advances in Biology and Medicine, 2. pp. 5-10. ISSN 2378-654X (doi:https://doi.org/10.18639/RABM.2016.02.271146)

Tetrapleura tetraptera, Skin, Excision wound, Incision wound, Epithelialization, Tensile strength

Tsala, David Emery, Habtemariam, Solomon, Simplice, Foyet Harquin, Ndzana, Martin Thierry Bella, Jital, Abraham Abraham and Dimo, Theophile (2014) Topically applied Tetrapleura tetraptera stem bark extract promotes healing of excision and incision wounds in rats. Journal of Intercultural Ethnopharmacology, 3 (2). pp. 63-67. ISSN 2146-8397 (doi:https://doi.org/10.5455/jice.20140129034637)

Urolithiasis, Aerva lanata, Calcium hydrogen phosphate Dihydrate, SEM, EDX, FT-IR, TGA/DTA and XRD.

Varghese, George K., Diana, K. J. and Habtemariam, Solomon (2014) In vitro studies on indigenous medicine for urolithiasis: Efficacy of aqueous extract of Aerva lanata (Linn.) Juss. Ex Schult on growth inhibition of calcium hydrogen phosphate dihydrate. The Pharma Innovation International Journal, 3 (1). pp. 92-100. ISSN 2349-8242 (Print), 2277-7695 (Online)

activity-guided isolation, free radical-scavenging components, ethanolic extract, boneset, Eupatorium perfoliatum

Habtemariam, S. (2008) Activity-guided isolation and identification of free radical-scavenging components from ethanolic extract of boneset (leaves of Eupatorium perfoliatum). Natural Product Communications, 3 (8). pp. 1317-1320. ISSN 1934-578X (Print), 1555-9475 (Online)

animals, anti-Inflammatory Agents, cell adhesion, endothelial cells, humans, leukocytes, plant extracts, plants, medicinal

Habtemariam, S. (2010) Applying new science for old medicines: targeting leukocyte-endothelial adhesions by antiinflammatory herbal drugs. Natural Product Communications, 5 (8). pp. 1329-1336. ISSN 1934 578X (printed), 1555 9475 (online)

anopyxis klaineana; rhizophoraceae; methyl angolensate; antinflammatory, carrageenan

Mireku, Evelyn A., Mensah, Abraham Y., Mensah, Merlin L. K., Tocher, Derek A. and Habtemariam, Solomon (2014) Antiinflammatory properties of the stem-bark of anopyxis klaineana and its major constituent, methyl angolensate. Phytotherapy Research, 28 (12). pp. 1855-1860. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.5212)

anti-inflammatory, antioxidant, diabetes, enzyme inhibition, fatty acids metabolism, glucose metabolism, polyphenols, receptor modulation

Habtemariam, Solomon and Varghese, George K. (2014) The antidiabetic therapeutic potential of dietary polyphenols. Current Pharmaceutical Biotechnology, 15 (4). pp. 391-400. ISSN 1389-2010 (Print), 1873-4316 (Online) (doi:https://doi.org/10.2174/1389201015666140617104643)

antioxidant enzymes, brain, oxidative stress, sodium fluoride

Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon, Akbar Hajizadeh, Moghaddam, Sureda, Anton and Mirzaei, Morteza (2012) Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats. Cellular and Molecular Neurobiology, 33 (2). pp. 261-267. ISSN 0272-4340 (Print), 1573-6830 (Online) (doi:https://doi.org/10.1007/s10571-012-9893-4)

antioxidant enzymes, lipid peroxidation, liver function markers, peltiphyllum peltatum, oxidative stress, sodium fluoride intoxication

Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon, Moghaddamd, Akbar Hajizadeh, Sureda, Antoni, Jafari, Mahtab and Latifia, Ali Mohammad (2012) Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress. Industrial Crops and Products, 44. pp. 50-55. ISSN 0926-6690 (doi:https://doi.org/10.1016/j.indcrop.2012.10.024)

antioxidant, baicalin, baicalein, flavonoid, mitochondria

Roberto de Oliveira, Marcos, Nabavi, Seyed Fazel, Habtemariam, Solomon, Erdogan Orhan, Ilkay, Daglia, Maria and Nabavi, Seyed Mohammad (2015) The effects of baicalein and baicalin on mitochondrial function and dynamics: A review. Pharmacological Research, 100. pp. 296-308. ISSN 1043-6618 (doi:https://doi.org/10.1016/j.phrs.2015.08.021)

antioxidant, cytotoxicity, DNA damage, methyl-3-0-methyl gallate, peltiphyllum peltatum, prooxidant, reactive oxygen species

Habtemariam, Solomon (2011) Methyl-3-O-methyl gallate and gallic acid from the leaves of peltiphyllum peltatum: Isolation and comparative antioxidant, prooxidant, and cytotoxic effects in neuronal cells. Journal of Medicinal Food, 14 (11). pp. 1412-1418. ISSN 1557-7600 (online) (doi:https://doi.org/10.1089/jmf.2010.0257)

azetidine; ligand efficiency metrics; lipophilicity; neurodegeneration; nicotinic acetylcholine receptors; pain; schizophrenia; smoking cessation

Degennaro, Leonardo, Zenzola, Marina, Laurino, Annunziatina, Cavalluzzi, Maria Maddalena, Franchini, Carlo, Habtemariam, Solomon, Matucci, Rosanna, Luisi, Renzo and Lentini, Giovanni (2017) 2-Arylazetidines as ligands for nicotinic acetylcholine receptors. Chemistry of Heterocyclic Compounds, 53 (3). pp. 329-334. ISSN 0009-3122 (Print), 1573-8353 (Online) (doi:https://doi.org/10.1007/s10593-017-2061-5)

cancer; carcinogenesis; metastasis; genipin; geniposide; reactive oxygen species; apoptosis; uncoupling protein 2

Habtemariam, Solomon and Lentini, Giovanni (2018) Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin. Biomedicines, 6 (2):39. ISSN 2227-9059 (Online) (doi:https://doi.org/10.3390/biomedicines6020039)

cardioprotective, gallic acid, peltiphyllum peltatum, homogenate, sodium fluoride

Habtemariam, Solomon, Sureda, Antony, Moghaddam, Akbar Hajizadeh, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad and Abolhasani, Fatemeh (2013) Protective role of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat’s heart. Letters in Drug Design and Discovery, 10 (3). pp. 277-282. ISSN 1570-1808 (Print), 1875-628X (Online) (doi:https://doi.org/10.2174/1570180811310030012)

cardiovascular drugs, Ebola, repurposing

Lentini, Giovanni and Habtemariam, Solomon (2015) Ebola therapy: Developing new drugs or repurposing old ones? International Journal of Cardiology, 179. p. 325. ISSN 0167-5273 (doi:https://doi.org/10.1016/j.ijcard.2014.11.092)

cassia auriculata, caesalpiniaceae, antioxidant, kaemperol-3-O-rutinoside, quercetin, luteolin, kaempferol

Juan-Badaturuge, Malindra, Habtemariam, Solomon and Thomas, Michael J. K. (2011) Antioxidant compounds from a South Asian beverage and medicinal plant, Cassia auriculata. Food Chemistry, 125 (1). pp. 221-225. ISSN 0308-8146 (doi:https://doi.org/10.1016/j.foodchem.2010.08.065)

citron; lemon; orange; solvent-free extraction; pseudomonads; staphylococci; Escherichia

Caputo, Leonardo, Quintieri, Laura, Cavalluzzi, Maria Maddalena, Lentini, Giovanni and Habtemariam, Solomon (2018) Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods. Biomedicines, 6 (2):70. ISSN 2227-9059 (Online) (doi:https://doi.org/10.3390/biomedicines6020070)

cytotoxic activity, knipholone anthrone, knipholone

Habtemariam, S. and Dagne, E. (2009) Differential cytotoxic and prooxidnant activity of knipholone and knipholone anthrone. Planta Medica, 75 (9). SL5-SL5. ISSN 0032-0943 (doi:https://doi.org/10.1055/s-0029-1234260)

dietary anthocyanins; insulin resistance; diabetes; obesity

Belwal, Tarun, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad and Habtemariam, Solomon (2017) Dietary anthocyanins and insulin resistance: When food becomes a medicine. Nutrients, 9 (10):1111. ISSN 2072-6643 (doi:https://doi.org/10.3390/nu9101111)

erythrophleum ivorense, fabaceae, erythroivorensin, betulinic acid, eriodictyol, anti-inflammatory, novel diterpene

Armah, Francis A., Annan, Kofi, Mensah, Abraham Y., Amponsah, Isaac K., Tocher, Derek A. and Habtemariam, Solomon (2015) Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.). Fitoterapia, 105. pp. 37-42. ISSN 0367-326X (doi:https://doi.org/10.1016/j.fitote.2015.06.001)

kaempferol, quercetin, rutin

Habtemariam, S. (2011) A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside. Natural Product Communications, 6 (2). pp. 201-203. ISSN 1934-578X (Printed), 1555-9475 (Online)

kidney, oxidative stress, quercetin, sodium fluoride, nephroprotection

Nabavi, Seyed Mohammad, Nabavi, Seyed Fazel, Habtemariam, Solomon, Moghaddam, Akbar Hajizadeh and Latifi, Ali Mohammad (2012) Ameliorative effects of quercetin on sodium fluoride-induced oxidative stress in rat's kidney. Renal Failure, 34 (7). pp. 901-906. ISSN 0886-022X (Print), 1525-6049 (Online) (doi:https://doi.org/10.3109/0886022X.2012.687347)

knipholone anthrone, Kniphofia foliosa, antioxidant activity, DPPH, reducing power, superoxide anion, hydroxyl radical, iron chelation, DNA damage

Habtemariam, Solomon (2007) Antioxidant activity of Knipholone anthrone. Food Chemistry, 102 (4). pp. 1042-1047. ISSN 0308-8146 (doi:https://doi.org/10.1016/j.foodchem.2006.06.040)

knipholone, knipholone anthrone, copper, reactive oxygen species, DNA damage

Habtemariam, S. and Dagne, E. (2009) Prooxidant action of knipholone anthrone: Copper dependent reactive oxygen species generation and DNA damage. Food and Chemical Toxicology, 47 (7). pp. 1490-1494. ISSN 0278-6915 (doi:https://doi.org/10.1016/j.fct.2009.03.032)

molecular weight, Peltiphyllum Peltatum, antioxicant, neuroprotection, antidiabetic

Habtemariam, S. (2012) Multifunctional small molecular weight compounds from Peltiphyllum Peltatum: From antioxicant to neuroprotection and antidiabetic effects. Planta Medica, 11 (78):PD4. ISSN 0032-0943 (Print), 1439-0221 (Online) (doi:https://doi.org/10.1055/s-0032-1320362)

monoterpenes; iridoids; Alzheimer’s disease; amyloid beta; drug likeness; multiple mechanisms

Habtemariam, Solomon (2018) Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects. Molecules, 23 (1):117. ISSN 1420-3049 (doi:https://doi.org/10.3390/molecules23010117)

sigmoidin A, eriodictyol, prooxidant, DNA damage, cytotoxicity, Erythrina abyssinica, Fabaceae

Habtemariam, Solomon and Dagne, Ermias (2010) Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol. Planta Medica, 76 (6). pp. 589-594. ISSN 0032-0943 (doi:https://doi.org/10.1055/s-0029-1240604)

tanacetum vulgare, asteraceae, 3,5-O-dicaffeoylquinic acid, axillarin, luteolin, antioxidant

Juan-Badaturuge, M., Habtemariam, S., Jackson, C. and Thomas, M. J. (2009) Antioxidant principles of Tanacetum vulgare L. aerial parts. Natural Product Communications, 4 (11). pp. 1561-1564. ISSN 1934-578X (Print), 1555-9475 (Online)

tanacetum vulgare, tansy, antiviral, HSV, ethnomedicine

Álvarez, Ángel L., Habtemariam, Solomon, Juan-Badaturuge, Malindra, Jackson, Caroline and Parra, Francisco (2010) In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action. Phytotherapy Research, 25 (2). pp. 296-301. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.3382)

two mammalian cell lines (HeLa and RAW 264.7), Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, fractionation

Sánchez-Medina, A., Peña-Rodríguez, L. M., May-Pat, F., Karagianis, G., Waterman, P. G., Mallet, A. and Habtemariam, S. (2010) Identification of sakurasosaponin as a cytotoxic principle from Jacquinia flammea. Natural Product Communications, 5 (3). pp. 365-368. ISSN 1934 578X (printed), 1555 9475 (online)