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Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia

Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia

Roselli, Mariagrazia, Lentini, Giovanni and Habtemariam, Solomon (2011) Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia. Phytotherapy Research, 26 (6). pp. 908-914. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:https://doi.org/10.1002/ptr.3655)

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Abstract

The antioxidant, anti-α-glucosidase and anticholinesterase activity of the leaves and rhizomatous extract of Bergenia cordifolia were investigated. The rhizomes extract that showed a higher degree of 1,1-diphenyl-2-picrylhydrazyl radical scavenging and anti-α-glucosidase activity than reference compounds (rutin and acarbose respectively) were subjected to phytochemical analysis. The study revealed that previously unknown minor constituents from the plant, (+)-catechin 3-O-gallate, (+)-catechin 3,5-di-O-gallate and 1,2,4,6-tetra-O-galloyl-β- d-glucopyranoside, were the radical scavenging and anti-α-glucosidase principles. These compounds as well as the crude extracts were weak acetylcholienesterase inhibitors, suggesting a higher degree of selectivity against α-glucosidase enzyme. In comparison with the minor constituents, the previously known major constituents of the plant, bergenin and arbutin, were poor radical scavengers and enzyme inhibitors.

Item Type: Article
Additional Information: [1] Copyright: © 2011 John Wiley & Sons, Ltd
Uncontrolled Keywords: Bergenia cordifolia, Saxifragaceae, antioxidant, anti-α-glucosidase, anticholinesterase, (+)-catechin gallates, 1,2,4,6-tetra-O-galloyl-β- d-glucopyranoside
Subjects: R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
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Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/13456

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