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Protective role of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat’s heart

Protective role of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat’s heart

Habtemariam, Solomon, Sureda, Antony, Moghaddam, Akbar Hajizadeh, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad and Abolhasani, Fatemeh (2013) Protective role of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat’s heart. Letters in Drug Design and Discovery, 10 (3). pp. 277-282. ISSN 1570-1808 (Print), 1875-628X (Online) (doi:https://doi.org/10.2174/1570180811310030012)

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Abstract

The purpose of this study was to examine the potential cardioprotective role of gallic acid, a natural phenolic acid isolated from Peltiphyllum peltatum, against sodium fluoride-induced oxidative stress in rat’s heart. Oxidative stress and cardiotoxicity were induced by drinking water containing 600 ppm of sodium fluoride (NaF) for a week. For determination of cardioprotective role of gallic acid, 10 and 20 mg/kg doses were intraperitoneally administrated daily for a week prior to NaF intoxication. Thiobarbituric acid reactive substances (TBARS), antioxidant enzyme activities (i.e. superoxide dismutase and catalase) and the level of non-enzymatic antioxidant (reduced glutathione) were evaluated in the homogenates of rat’s cardiac tissues. Vitamin C (10 mg/kg) was used as standard antioxidant for comparison. Thiobarbituric acid reactive substance levels in heart homogenates of NaF intoxicated rats significantly increased (59.36 ± 2.19 nmol MDA eq/g tissue) when compared with control group (43.51 ± 1.47 nmol MDA eq/g tissue) (P<0.001). Administration of gallic acid at 20 mg/kg resulted in a significant decrease in TBARS levels (48.48 ± 1.81 nmol MDA eq/g tissue) (P>0.05 vs. normal). Antioxidant enzyme activities and glutathione levels were significantly reduced in NaF-treated animals (P<0.001 vs. normal). Gallic acid of Peltiphyllum peltatum at 20 mg/kg totally reversed (P>0.05 vs. control group) the oxidative stress induced by NaF as evidenced from the measured biochemical markers: superoxide dismutase (102.21 ± 1.29 U/g tissue) and catalase (39.29 ± 1.49 μmol/min/mg protein) activities and reduced glutathione (5.11 ± 0.09 μg/mg protein) levels. We concluded that gallic acid mitigated NaF induced oxidative stress in rat heart.

Item Type: Article
Additional Information: [1] Copyright © Bentham Science Publishers. All Rights Reserved.
Uncontrolled Keywords: cardioprotective, gallic acid, peltiphyllum peltatum, homogenate, sodium fluoride
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/13429

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