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Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

Shirooie, Samira, Nabavi, Seyed Fazel, Dehpour, Ahmad R., Belwal, Tarun, Habtemariam, Solomon, Argüelles, Sandro, Sureda, Antoni, Daglia, Maria, Tomczyk, Michał, Sobarzo-Sanchez, Eduardo, Xu, Suowen and Nabavi, Seyed Mohammad (2018) Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration? Pharmacological Research, 135. pp. 37-48. ISSN 1043-6618 (Print), 1096-1186 (Online) (doi:https://doi.org/10.1016/j.phrs.2018.07.004)

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Abstract

Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects. This review now assesses the potential of this class of compounds in NDs therapy through specific action against the mammalian target of rapamycin (mTOR) signaling pathway. The role of mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed.

Item Type: Article
Uncontrolled Keywords: Neurodegenerative diseases; mTOR; omega-3; Docosahexaenoic acid; Eicosapentaenoic acid
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 29 Nov 2018 17:34
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/22281

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