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Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells

Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells

Habtemariam, S. (2010) Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia, 81 (8). pp. 1013-1019. ISSN 0367-326X (doi:https://doi.org/10.1016/j.fitote.2010.06.021)

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Abstract

The present study examines the comparative cytotoxicity of knipholone (KP) and knipholone anthrone (KA) in leukameic and melonocyte cancer cell lines. It was found that KA induces a rapid onset of cytotoxicity with IC50 values ranging from 0.5 - 3.3 mM. In comparison to KA, KP was 70-480-times less toxic to cancer cells. Morphological and biochemical studies revealed that the cytotoxicity of KA was coupled with a quick loss of membrane integrity leading to necrotic cell death. The study identified KA as a new class of natural potential anticancer agent with a wide range of toxicological and pharmacological implications.

Item Type: Article
Uncontrolled Keywords: Kniphofia foliosa (Asphodelaceae), Knipholone, Knipholone anthrone, cytotoxicity, apoptosis, necrosis
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 16:55
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/3518

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