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Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress

Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress

Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon, Moghaddamd, Akbar Hajizadeh, Sureda, Antoni, Jafari, Mahtab and Latifia, Ali Mohammad (2012) Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress. Industrial Crops and Products, 44. pp. 50-55. ISSN 0926-6690 (doi:https://doi.org/10.1016/j.indcrop.2012.10.024)

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Abstract

In the present study, the possible protective effects of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride (NaF)-induced hepatotoxicity and oxidative stress were evaluated. Rats were intoxicated with 600 ppm NaF through drinking water for one week. Gallic acid (10 and 20 mg/kg) and the positive control, silymarin (10 mg/kg) were administrated for seven days prior to NaF intoxication. 24 h after the treatment period, superoxide dismutase and catalase activities, lipid peroxidation and reduced glutathione levels were measured in the liver. Serum biochemical markers including: alanine transaminase, aspartate aminotransferase, alkaline phosphatase, lipase and α-amylase activities and triglyceride, cholesterol, glucose, total bilirubin, direct bilirubin, total protein and albumin levels were determined. The results demonstrated that pretreatment with gallic acid normalized the sodium fluoride-induced alterations in serum parameters and oxidative stress in hepatic tissue. Fluoride intoxication resulted in an increased level of thiobarbituric acid reactive substances (TBARS) (53.05 ± 2.23 nmol MDA equiv./g tissue) in the liver homogenates in comparison with control group (25.03 ± 1.27 nmol MDA equiv./g tissue). Pretreatment with gallic acid at 20 mg/kg demonstrated significant mitigation in TBARS level (33.95 ± 2.51 nmol MDA equiv./g tissues). Fluoride intoxication did also suppress the superoxide dismutase and catalase activity of hepatic tissue homogenates by 33.87% and 66.87%, respectively. Treatment with gallic acid resulted in a dose-dependent mitigation of the fluoride-mediated suppression of antioxidant enzymes. In conclusion, gallic acid prevented the NaF-induced abnormalities in the serum and hepatic biochemical markers.

Item Type: Article
Additional Information: [1] Acknowledgements (funding): This study was partly supported by the research grant of University of Greenwich (UK) and National Elite's Foundation of Iran (Iran) for this study. [2] Copyright © 2015 Elsevier B.V. All rights reserved
Uncontrolled Keywords: antioxidant enzymes, lipid peroxidation, liver function markers, peltiphyllum peltatum, oxidative stress, sodium fluoride intoxication
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
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Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/13431

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