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Applying new science for old medicines: targeting leukocyte-endothelial adhesions by antiinflammatory herbal drugs.

Applying new science for old medicines: targeting leukocyte-endothelial adhesions by antiinflammatory herbal drugs.

Habtemariam, S. (2010) Applying new science for old medicines: targeting leukocyte-endothelial adhesions by antiinflammatory herbal drugs. Natural Product Communications, 5 (8). pp. 1329-1336. ISSN 1934 578X (printed), 1555 9475 (online)

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Abstract

During the last two decades, considerable progress has been made in understanding the molecular mechanisms of the various leukocytes and endothelial cell adhesion molecules (cell adhesion molecules - CAMs) involved in cell-cell and cell matrix interactions. This understanding has opened up a new avenue of novel chemotherapeutic targets and bioassay models for inflammatory diseases. Recently developed in vitro bioassays on leukocyte/endothelial cell adhesions can now offer rapid and inexpensive assessment methods for herbal medicines with claimed antiinflammatory uses. Through the use of these robust in vitro methods, active principles of herbal drugs can also be isolated thereby providing the opportunity of standardizations based on a known chemical standard(s) and pharmacology. This review highlights relevant leukocyte/endothelial CAMs targets, available in vitro methods and our strategic approach for herbal standardizations.

Item Type: Article
Uncontrolled Keywords: animals, anti-Inflammatory Agents, cell adhesion, endothelial cells, humans, leukocytes, plant extracts, plants, medicinal
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 16:54
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7652

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