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The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy

The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy

Habtemariam, Solomon (2011) The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy. Natural Product Communications, 6 (8). pp. 1089-1090. ISSN 1934-578X (Print), 1555-9475 (Online)

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Abstract

Berberis darwinii is native to South America but has been widely distributed in Europe and other continents following its discovery by Charles Darwin. Herewith, the therapeutic potential of stem-bark of the plant for treating Alzheimer's disease was studied using an in vitro acetylcholinesterase inhibition assay. It was found that the methanolic extract of the stem-bark was a potent inhibitor of the enzyme with an IC50 value of 1.23 ± 0.05 μg/mL. An HPLC-based berberine quantification study revealed an astonishing 38% yield of the dried methanolic extract.

Item Type: Article
Uncontrolled Keywords: Acetylcholinesterase, Alzheimer's disease, Berberidaceae, Berberine, Berberis darwinii
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Related URLs:
Last Modified: 14 Oct 2016 09:18
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/7381

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