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Antidepressant-like activity of Embelin isolated from Embelia ribes

Antidepressant-like activity of Embelin isolated from Embelia ribes

Gupta, Gaurav, Kazmi, Imran, Afzal, Muhammad, Upadhyay, Gaurav, Singh, Rajnish and Habtemariam, Solomon (2013) Antidepressant-like activity of Embelin isolated from Embelia ribes. Phytopharmacology, 4 (1). pp. 87-95. ISSN 2046-1194

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Various preparations of Embelia ribes are used in Indian traditional medicine as brain tonic and for treating mental disorders. The aim of the present study was to evaluate the major known active principle of Embelia ribes for possible antidepressant activity. Fractionation of the methanlic extract of dried powdered fruits (?) using column chromatography over silica gel afforded embelin. Experimental depression was induced by subjecting mice to tail suspension test (TST) and forced swimming test (FST) experimental models. Intraperitonial administration of embelin (2.5 and 5 mg/kg) 30 min prior to induction of experimental depression resulted in dose-dependent reduction of immobility under both test conditions. The effect of embelin at the dose of 5 mg/kg in both experimental models was comparable with the standard antidepressant drug, imipramine administered at the dose of 15 mg/kg. It is concluded that Embelia ribes and its major bioactive compound, embelin, have therapeutic potential for managing depression.

Item Type: Article
Additional Information: [1] Copyright: © 2013 Inforesights Publishing UK. [2] Phytopharmacology is an international peer-reviewed open-access journal (
Uncontrolled Keywords: Embelia ribes, Myrsinaceae, embelin, antidepressant, imipramine, tail suspension test, forced swimming test
Subjects: Q Science > QK Botany
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
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Last Modified: 06 Dec 2016 11:48

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