3D bioprinting, bioink, chitosan, genipin, human dermal fibroblasts, primary epidermal keratinocytes, skin regeneration

Hafezi, Forough, Shorter, Susan, Tabriz, Atabak Ghanizadeh, Hurt, Andrew P., Elmes, Victoria, Boateng, Joshua ORCID: 0000-0002-6310-729X and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2020) Bioprinting and preliminary testing of highly reproducible novel bioink for potential skin regeneration. Pharmaceutics, 12 (6):550. ISSN 1999-4923 (Print), 1999-4923 (Online) (doi:https://doi.org/10.3390/pharmaceutics12060550)

3D printing, 3D bioprinting, biomaterials, human skin tissue, extracellular matrix

Tabriz, Atabak Ghanizadeh, Douroumis, Dennis ORCID: 0000-0002-3782-0091 and Boateng, Joshua ORCID: 0000-0002-6310-729X (2019) 3D printed scaffolds for wound healing and tissue regeneration. In: Boateng, Joshua ORCID: 0000-0002-6310-729X , (ed.) Therapeutic Dressings and Wound Healing Applications. Wiley, pp. 385-398. ISBN 978-1119433262

3D printing, Inkjet coating, Insulin, Microneedles

Pere, Cristiane Patricia Pissinato, Economidou, Sophia N., Lall, Gurprit, Ziraud, Clémentine, Boateng, Joshua ORCID: 0000-0002-6310-729X , Alexander, Bruce D., Lamprou, Dimitrios A. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2018) 3D printed microneedles for insulin skin delivery. International Journal of Pharmaceutics, 544 (2). pp. 425-432. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2018.03.031)

3D printing, Paediatric medicines, Fusion deposition modelling, Hot melt extrusion, Taste masking

Scoutaris, Nikolaos, Ross, Steven A. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2018) 3D printed "Starmix" drug loaded dosage forms for paediatric applications. Pharmaceutical Research, 35. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:https://doi.org/10.1007/s11095-017-2284-2)

3D printing; Chitosan; Film scaffolds; Genipin; Plasticiser; Tensile testing; Wound healing

Boateng, Joshua ORCID: 0000-0002-6310-729X , Hafezi, Forough, Scoutaris, Nikolaos and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2019) 3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds. International Journal of Pharmaceutics, 560. pp. 406-415. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2019.02.020)

3D printing; Chitosan; collagen; epidermal growth factor; films; wound healing

Boateng, Joshua ORCID: 0000-0002-6310-729X , Hafezi, Forough, Tabriz, Atabak and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2023) 3D printed composite dressings loaded with human epidermal growth factor for potential chronic wound healing applications. Journal of Drug Delivery Science and Technology, 86:104684. pp. 1-13. ISSN 1773-2247 (Print), 2588-8943 (Online) (doi:https://doi.org/10.1016/j.jddst.2023.104684)

3D printing; Microneedles; Inkjet coating; Insulin; μCT

Economidou, Sophia N., Pissinato Pere, Cristiane Patricia, Reid, Andrew, Uddin, Jasim Md., Windmill, James F.C., Lamprou, Dimitrios A. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2019) 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Materials Science and Engineering C, 102. pp. 743-755. ISSN 0928-4931 (doi:https://doi.org/10.1016/j.msec.2019.04.063)

3D printing; digital light processing; microneedles; piercing; mechanical properties; biocompatibility

Ghanizadeh Tabriz, Atabak, Viegas, Beatriz, Okereke, Michael ORCID: 0000-0002-2104-012X , Uddin, Md Jasim, Arribas Lopez, Elena, Zand Fard, Nazanin ORCID: 0000-0003-2058-2354 , Ranatunga, Medhavi, Getti, Giulia ORCID: 0000-0003-1402-8496 and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2022) Evaluation of 3D printability and biocompatibility of microfluidic resin for fabrication of solid microneedles. Micromachines, 13:1368. pp. 1-16. ISSN 2072-666X (Online) (doi:https://doi.org/10.3390/mi13091368)

3D printing; microneedle systems

Economidou, Sophia N. and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2021) 3D printing as a transformative tool for microneedle systems: recent advances, manufacturing considerations and market potential. Advanced Drug Delivery Reviews, 173. pp. 60-69. ISSN 0169-409X (Print), 1872-8294 (Online) (doi:https://doi.org/10.1016/j.addr.2021.03.007)

3D printing; oral solid dosage forms; controlled release; isoniazid; rifampicin; tuberculosis

Ghanizadeh Tabriz, Atabak, Nandi, Uttom, Hurt, Andrew, Hui, Ho-Wah, Karki, Shyam, Gong, Yuchuan, Kumar, Sumit and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2020) 3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment. International Journal of Pharmaceutics, 593:120147. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2020.120147)

3D printing; selective laser sintering; personalised medicines; oral; carvedilol

Ghanizadeh Tabriz, Atabak, Gonot-Munck, Quentin, Baudoux, Arnaud, Garg, Vivek ORCID: 0000-0002-8515-4759 , Farnish, Richard, L.Katsamenis, Orestis, Hui, Ho-Wah, Boersen, Nathan, Roberts, Sandra, Jones, John and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2023) 3D printing of personalised Carvedilol tablets using selective laser sintering. Pharmaceutics, 15 (9):2230. pp. 1-19. ISSN 1999-4923 (Online) (doi:https://doi.org/10.3390/pharmaceutics15092230)

Acryl-EZE, Astree e-tongue, Eudragit L100, taste masking, TS5000Z

Maniruzzaman, Mohammed and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study. Journal of Pharmacy and Pharmacology, 67 (1). pp. 43-55. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12319)

Maniruzzaman, Mohammed and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) An in-vitro–in-vivo taste assessment of bitter drug: comparative electronic tongues study. Journal of Pharmacy and Pharmacology, 67 (1). pp. 43-55. ISSN 0022-573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12319)

Amorphous; Continuous manufacturing; Energy dispersive X-ray; Oral strips; Surface analysis

Maniruzzaman, Mohammed, Farias, Smirna, Slipper, Ian J., Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Chowdhry, Babur Z., Nair, Arun and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2016) Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Journal of Pharmacy and Pharmacology, 68 (7). pp. 890-900. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12569)

Bitter APIs; Hot melt extrusion; Inter-molecular interactions; Modified release; Molecular dispersion; Taste assessment; Taste masking

Maniruzzaman, Mohammed, Boateng, Joshua ORCID: 0000-0002-6310-729X , Chowdhry, Babur, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) A review on the taste masking of bitter APIs: Hot-melt extrusion (HME) evaluation. Drug Development and Industrial Pharmacy, 40 (2). pp. 145-156. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:https://doi.org/10.3109/03639045.2013.804833)

CDS quantum dots, synthesis, photoluminescence

Slipper, Ian J., Bhujval, Pranav, Rajaram, Sudha, Favretto, Marco E. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2010) A facile synthesis route of size tunable CdS quantum dots with high photoluminescence yield. Journal of Nanoscience and Nanotechnology, 10 (9). pp. 5899-5902. ISSN 1550-7033 (Print), 1550-7041 (Online) (doi:https://doi.org/10.1166/jnn.2010.2548)

Extrusion; Solid dispersions; Excipients; Drug – excipient interactions dissolution.

Maniruzzaman, M., Ross, S.A., Islam, M.T, Scoutaris, N., Nair, A. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy, 43 (6). pp. 947-957. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:https://doi.org/10.1080/03639045.2017.1287716)

General materials science, general chemistry, condensed matter physics

Ross, Steven A., Ward, Adam, Basford, Pat, McAllister, Mark and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2018) Coprocessing of pharmaceutical cocrystals for high quality and enhanced physicochemical stability. Crystal Growth & Design, 19 (2). pp. 876-888. ISSN 1528-7483 (Print), 1528-7505 (Online) (doi:https://doi.org/10.1021/acs.cgd.8b01440)

Granulations; DoE; QbD; Dissolutions; Twin screw; Raman; DVS

Maniruzzaman, Mohammed, Nair, Arun, Renault, Maxcene, Nandi, Uttom ORCID: 0000-0003-1777-3862 , Scoutaris, Nicholaos, Farnish, Richard, Bradley, Mike, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug. International Journal of Pharmaceutics Special Issue on "Continuous Manufacturing and Process Analytical Tools”, 496 (1). ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2015.09.025)

HME, taste masking

Maniruzzaman, M., Boateng, J. ORCID: 0000-0002-6310-729X and Douroumis, D. ORCID: 0000-0002-3782-0091 (2011) Taste masking of bitter APIs by using hot melt extrusion (HME). In: AAPS Journal. American Association of Pharmaceutical Sciences, Arlington, VA, USA, T3273-T3273. ISSN 1550-7416 (on-line)

Hot melt extrusion, polymers, medical devices, solubility parameters, scale-up

Douroumis, Dennis ORCID: 0000-0002-3782-0091 (ed.) (2012) Hot-Melt Extrusion: pharmaceutical applications. Advances in Pharmaceutical Technology . John Wiley & Sons, Ltd., Chichester, UK. ISBN 9780470711187

Hot melt extrusion; Taste masking; Solubility increase; Process technology; Formulation

Maniruzzaman, Mohammed, Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) A review of hot-melt extrusion: process technology to pharmaceutical products [Review article]. ISRN Pharmaceutics, 2012:436763. pp. 1-9. ISSN 2090-6145 (Print), 2090-6153 (Online) (doi:https://doi.org/10.5402/2012/436763)

Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity

Potta, Sriharsha Gupta, Minemi, Sriharsha, Nukala, Ravi Kumar, Peinado, Chairmane, Lamprou, Dimitios A., Urquhart, Andrew and Douroumis, D. ORCID: 0000-0002-3782-0091 (2011) Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28 (1). pp. 74-81. ISSN 0265-2048 (Print), 1464-5246 (Online) (doi:https://doi.org/10.3109/02652048.2010.529948)

Indomethacin, In-line monitoring, Reflectance; Transmission, Near infrared spectroscopy, Process analytical technology, Hot-melt extrusion, Molecular solutions, Raman mapping

Islam, Muhammad T., Scoutaris, Nikolaos, Maniruzzaman, Mohammed, Moradiya, Hiren G., Halsey, Sheelagh, Bradley, Michael, Chowdhry, Babur, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. European Journal of Pharmaceutics and Biopharmaceutics, 96. pp. 106-116. ISSN 0939-6411 (Print), 1873-3441 (Online) (doi:https://doi.org/10.1016/j.ejpb.2015.06.021)

Inorganic excipients; Solid dispersions; Continuous extrusion

Maniruzzaman, M., Nair, A., Scoutaris, N., Bradley, Michael S.A., Snowden, M.J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2015) One-step continuous extrusion process for the manufacturing of solid dispersions. International Journal of Pharmaceutics Special Issue on "Continuous Manufacturing and Process Analytical Tools”, 496 (1). pp. 42-51. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2015.09.048)

Jet dispensing; Films; Combination therapy; Antihypertensive drugs

Scoutaris, Nicolaos, Malamatari, Maria, Letellier, Adrien and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2017) Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents. Drug Delivery and Translational Research, 8 (1). pp. 32-42. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:https://doi.org/10.1007/s13346-017-0430-3)

Laponite; alginate; composite particles; theophylline; pH-dependent release

Nandi, Uttom ORCID: 0000-0003-1777-3862 , Trivedi, Vivek ORCID: 0000-0001-9304-9214 , Douroumis, Dennis ORCID: 0000-0002-3782-0091 , Mendham, Andrew P. and Coleman, Nichola J. (2020) Layered Silicate-Alginate Composite Particles for the pH-Mediated Release of Theophylline. Pharmaceuticals, 13 (8):182. ISSN 1424-8247 (Online) (doi:https://doi.org/10.3390/ph13080182)

Microelectromechanical Systems; 3D printing; microneedles; Optical Coherence Tomography; in vivo

Economidou, Sophia N., Uddin, Md. Jasim, Marques, Manuel J., Douroumis, Dennis ORCID: 0000-0002-3782-0091 , Ting Sow, Wan, Li, Huaqiong, Reid, Andrew, Windmill, James F.C. and Podoleanu, Adrian (2020) A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalised transdermal drug delivery. Additive Manufacturing, 38:101815. ISSN 2214-7810 (Print), 2214-8604 (Online) (doi:https://doi.org/10.1016/j.addma.2020.101815)

Microneedles, coating, jet-dispensing

University of Greenwich (2013) Method of coating microneedle devices. WO 2013/038137.

Nutraceuticals; Fish oil microencapsulation; Hydroxy propyl methyl cellulose acetate succinate (HPMCAS); Docosahexaenoic acid (DHA); Spray-drying; Solid lipid nanoparticle (SLN)

Loughrill, Emma, Thompson, Sharon, Owusu-Ware, Samuel K., Snowden, Martin J. ORCID: 0000-0002-1087-2692 , Douroumis, Dennis ORCID: 0000-0002-3782-0091 and Zand Fard, Nazanin ORCID: 0000-0003-2058-2354 (2019) Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray–drying processing. Food Chemistry, 286. pp. 368-375. ISSN 0308-8146 (doi:https://doi.org/10.1016/j.foodchem.2019.01.121)

PMAA-Chitosan-PEG, nanoparticles, oral drug delivery, muco-adhesion

Pawar, H., Douroumis, D. ORCID: 0000-0002-3782-0091 and Boateng, J.S. ORCID: 0000-0002-6310-729X (2010) Preparation and optimization of PMAA-Chitosan-PEG nanoparticles for oral drug delivery. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1463-1464. ISSN 2042-7158 (Print), 0022-3573 (Online) (doi:https://doi.org/10.1111/j.2042-7158.2010.01178.x)

Pharmaceutics, Molecular, Modelling Drug Delivery,

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Fahr, A., Siepmann, J. and Snowden, Martin ORCID: 0000-0002-1087-2692 (eds.) (2015) Computational pharmaceutics: application of molecular modeling in drug delivery. Advances in Pharmaceutical Technology . Wiley-Blackwell. ISBN 978-1118573990

Solid, Dispersions, Surface, Analysis

Maniruzzaman, Mohammed, Snowden, Martin ORCID: 0000-0002-1087-2692 , Bradley, Michael and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2015) Correction: Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis. RSC Advances, 5 (103). p. 84936. ISSN 2046-2069 (Online) (doi:https://doi.org/10.1039/c5ra90091c)

Stent, 3D printing

The University Of Greenwich (2017) STENT WO 2016116748 A1. WO 2016116748 A1.

Ultrahigh Drug Loading, Biodegradable Porous Silicon, Aerocrystals, supercritical CO2

Nadarassan, D. K., Loni, A., Q. Shabir, Q., Kelly, C, O’Brien, H., Caffull, E., Webb, K., Canham, L. T., Maniruzamman, M, Trivedi, V. ORCID: 0000-0001-9304-9214 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2015) Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals. In: Controlled Release Society Meeting. CRS, pp. 42-43.

Wet granulation; DoE; QbD; Dissolution rate; Specific surface area; Water sorption

Maniruzzaman, Mohammed, Ross, Steven A., Dey, Tumpa, Nair, Arun, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2017) A quality by design (QbD) twin–screw extrusion wet granulation approach for processing water insoluble drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 496-505. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2017.05.020)

Zeolite, In vitro, Insilico, Supercritical CO2

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Fatouros, Dimitrios, Nikolakis, Vladimiros, Ntais, Spyridon, Moschovi, Anastasia Maria, Trivedi, Vivek ORCID: 0000-0001-9304-9214 , Khima, Bhavin, Roldo, Marta, Nazar, Hamde and Cox, Paul A (2011) In vitro and in silico investigations of drug delivery via zeolite BEA. Journal of Materials Chemistry, 21. pp. 7789-7794. ISSN 0959-9428 (Print), 1364-5501 (Online) (doi:https://doi.org/10.1039/C1JM10204D)

advanced surface chemical analysis; drug/polymer interactions

Maniruzzaman, Mohammed, Snowden, Martin ORCID: 0000-0002-1087-2692 , Bradley, Michael and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2015) Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis. RSC Advances: An international journal to further the chemical sciences, 5 (91). pp. 74212-74219. ISSN 2046-2069 (Online) (doi:https://doi.org/10.1039/C5RA13176F)

bioadhesion, chitosan, copolymerization, drug release, pH sensitive nanoparticles, polymethacrylic acid

Pawar, Harshavardhan, Douroumis, Dionysios ORCID: 0000-0002-3782-0091 and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2012) Preparation and optimization of PMAA–chitosan–PEG nanoparticles for oral drug delivery. Colloids and Surfaces B: Biointerfaces, 90. pp. 102-108. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2011.10.005)

bioadhesion, films, hot-melt extrusion

Boateng, Joshua ORCID: 0000-0002-6310-729X and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) Bioadhesion properties of polymeric films produced by hot-melt extrusion. In: Douroumis, Dennis ORCID: 0000-0002-3782-0091 , (ed.) Hot-Melt Extrusion: Pharmaceutical Applications. Advances in Pharmaceutical Technology . John Wiley & Sons, Ltd., Chichester, UK, pp. 177-200. ISBN 978-0-470-71118-7 (hbk), 978-1-1183-0787-8 (ebk)

buccal tablets, direct compression, controlled release, bioadhesion, kinetic models

Boyapally, Harikrishna, Nukala, Ravi Kumar, Bhujval, Pranav and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2010) Controlled release from directly compressible theophylline buccal tablets. Colloids and Surfaces B: Biointerfaces, 77 (2). pp. 227-233. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2010.01.031)

calcium alginate beads, hydrogels, swelling, release mechanism, Peppas model

Nochos, Argyrios, Douroumis, Dionysios ORCID: 0000-0002-3782-0091 and Bouropoulos, Nikolaos (2008) In vitro release of bovine serum albumin from alginate/HPMC hydrogel beads. Carbohydrate Polymers, 74 (3). pp. 451-457. ISSN 0144-8617 (doi:https://doi.org/10.1016/j.carbpol.2008.03.020)

carbon nanotubes, liposomes, drug delivery systems, Raman spectroscopy, ζ-potential

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Fatouros, Dimitrios G., Bouropoulos, Nikolaos, Papagelis, Konstas and Tasis, Dimitrios (2007) Colloidal stability of carbon nanotubes in an aqueous solution of phospholipids. International Journal of Nanomedicine, 2 (4). pp. 761-766. ISSN 1178-2013 (doi:https://doi.org/10.2147/IJN.S)

chitosan derivatives, hydroxyapatite, calcium phosphate implants, calcein, FITC-dextran, drug delivery

Green, S., Roldo, M., Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Bouropoulos, Nikolaos, Lamprou, D. and Fatouros, Dimitrios G. (2009) Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. Carbohydrate Research, 344 (7). pp. 901-907. ISSN 0008-6215 (doi:https://doi.org/10.1016/j.carres.2009.02.022)

coating, drug eluting stents, electrostatic deposition, platelet adhesion, supercritical fluids

Nukala, Ravi Kumar, Boyapally, Harikrishna, Slipper, Ian J., Mendham, Andrew P. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2009) The application of electrostatic dry powder deposition technology to coat drug-eluting stents. Pharmaceutical Research, 27 (1). pp. 72-81. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:https://doi.org/10.1007/s11095-009-0008-y)

complexation, drug delivery, microencapsulation, orally disintegrating tables, taste masking

Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2011) Orally disintegrating dosage forms and taste-masking technologies; 2010. Expert Opinion on Drug Delivery, 8 (5). pp. 665-675. ISSN 1742-5247 (Print), 1744-7593 (Online) (doi:https://doi.org/10.1517/17425247.2011.566553)

continuous cocrystallisation, carbamazepine, trans-cinnamic acid, melt extrusion processing

Moradiya, Hiren G., Islam, Muhammad T., Halsey, Sheelagh, Maniruzzaman, Mohammed, Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2014) Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing. CrystEngComm, 16 (17). pp. 3573-3583. ISSN 1466-8033 (doi:https://doi.org/10.1039/c3ce42457j)

drug delivery LNCap Apoptosis

Akanda, Mushfiq H., Rai, Rajeev, Slipper, Ian J., Chowdhry, Babur Z., Lamprou, Dimitrios, Getti, Giulia ORCID: 0000-0003-1402-8496 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Delivery of retinoic acid to LNCap human prostate cancer cells using solid lipid nanoparticles. International Journal of Pharmaceutics, 493 (1-2). pp. 161-171. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2015.07.042)

drug eluting stents, inkjet printing, PLA, paclitaxel, simvastatin, cytokines, implantation

Scoutaris, Nikolaos, Chai, Feng, Blandine, Maurel, Sobocinski, Jonathan, Zhao, Min, Moffat, Jonathan G., Craig, Duncan Q., Martel, Bernard, Blanchemain, Nicolas and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2016) Development and biological evaluation of Iinkjet printed drug coatings on intravascular stent. Molecular Pharmaceutics, 13 (1). pp. 125-133. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/acs.molpharmaceut.5b00570)

e-tongue, hot-melt extrusion, molecular dispersions, taste masking

Maniruzzaman, Mohammed, Bonnefille, Marion, Aranyos, Attila, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs. Journal of Pharmacy and Pharmacology, 66 (2). pp. 323-337. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12169)

extended release, FT-IR, ibuprofen, matrix tablet, polyethylene oxide, polymer combination, propranolol hydrochloride, sodium carboxymethylcellulose, theophylline

Palmer, Dasha, Levina, Marina, Nokhodchi, Ali, Douroumis, Dennis ORCID: 0000-0002-3782-0091 , Farrell, Tom and Rajabi-Siahboomi, Ali (2011) The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices. AAPS PharmSci Tech, 12 (3). pp. 862-871. ISSN 1530-9932 (Online) (doi:https://doi.org/10.1208/s12249-011-9648-4)

extrusion, lipids, solid dispersions, tablet, solid dosage form

Vithani, K., Maniruzzaman, M., Slipper, I.J., Mostafa, S., Miolane, C., Cuppok, Y., Marchaud, D. and Douroumis, D. ORCID: 0000-0002-3782-0091 (2013) Sustained release solid lipid matrices processed by hot-melt extrusion (HME). Colloids and Surfaces B: Biointerfaces, 110. pp. 403-410. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2013.03.060)

fatty acids, supercritical fluids, melting point depression

Trivedi, Vivek ORCID: 0000-0001-9304-9214 , Bhomia, Ruchir, Mitchell, John C. ORCID: 0000-0003-2945-3292 , Coleman, Nichola J., Douroumis, Dennis ORCID: 0000-0002-3782-0091 and Snowden, Martin J. ORCID: 0000-0002-1087-2692 (2013) Study of the effect of pressure on melting behavior of saturated fatty acids in liquid or supercritical carbon dioxide. Journal of Chemical & Engineering Data, 58 (6). pp. 1861-1866. ISSN 0021-9568 (Print), 1520-5134 (Online) (doi:https://doi.org/10.1021/je400260c)

hot melt extrusion, lipid matrices, surface mapping, sustained release

Vithani, K., Cuppok, Y., Mostafa, S., Slipper, I. J., Snowden, M. J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2014) Diclofenac sodium sustained release hot melt extruded lipid matrices. Pharmaceutical Development and Technology, 19 (5). pp. 531-538. ISSN 1083-7450 (Print), 1097-9867 (Online) (doi:https://doi.org/10.3109/10837450.2013.805775)

hot-melt extrusion, dissolution enhancement, solid dispersions, hydrophilic polymers, insoluble drugs

Maniruzzaman, M., Rana, M.M., Boateng, J. S. ORCID: 0000-0002-6310-729X , Mitchell, J. C. ORCID: 0000-0003-2945-3292 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2013) Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion using hydrophilic polymers. Drug Development and Industrial Pharmacy, 39 (2). pp. 218-227. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:https://doi.org/10.3109/03639045.2012.670642)

hot-melt extrusion, in-line NIR, process analytical technology, quality by design, critical quality attributes

Islam, Muhammad T., Maniruzzaman, Mohammed, Halsey, Sheelagh A., Chowdhry, Babur Z. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2014) Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach. Drug Delivery and Translational Research, 4 (4). pp. 377-387. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:https://doi.org/10.1007/s13346-014-0197-8)

hot-melt extrusion, taste masking, electronic tongue, solubility parameter

Maniruzzaman, Mohammed, Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Bonnefille, Marion, Arranyos, Attila, Mitchell, John C. ORCID: 0000-0003-2945-3292 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2011) Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 80 (2). pp. 433-442. ISSN 0939-6411 (doi:https://doi.org/10.1016/j.ejpb.2011.10.019)

hot-melt extrusion, taste masking, orally disintegrating tablets, Eudragit EPO

Gryczke, Andreas, Schminke, Silke, Maniruzzaman, Mohammed, Beck, Julien and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2011) Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids and Surfaces B: Biointerfaces, 86 (2). pp. 275-284. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2011.04.007)

ikjet printing, microneedles, release, transdermal delivery, anticancer drugs

Uddin, Md Jasim, Scoutaris, Nicolaos, Klepetsanis, Pavlos, Chowdry, Babur, Prausnitz, Mark R. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Inkjet printing of transdermal microneedles for the delivery of anticancer agents. International Journal of Pharmaceutics, 494 (2). pp. 593-602. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2015.01.038)

in vitro, in silico, drug delivery, zeolite BEA

Fatouros, Dimitrios G., Douroumis, Dennis ORCID: 0000-0002-3782-0091 , Nikolakis, Vladimiros, Ntais, Spyridon, Moschovi, Anastasia Maria, Trivedi, Vivek ORCID: 0000-0001-9304-9214 , Khima, Bhavin, Roldo, Marta, Nazar, Hamde and Cox, Paul A. (2011) In vitro and in silico investigations of drug delivery via zeolite BEA. Journal of Materials Chemistry, 21 (21). pp. 7789-7794. ISSN 0959-9428 (Print), 1364-5501 (Online) (doi:https://doi.org/10.1039/c1jm10204d)

in vitro-in vivo correlations (IVIVC), in vitro dynamic lipolysis model, self-emulsifying drug delivery systems, mathematical modelling, neuron-fuzzy networks

Fatouros, Dimitrios G., Nielsen, Flemming Seier, Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Hadjileontiadis, Leontios J. and Mullertz, Anette (2008) In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks. European Journal of Pharmaceutics and Biopharmaceutics, 69 (3). pp. 887-898. ISSN 0939-6411 (doi:https://doi.org/10.1016/j.ejpb.2008.01.022)

jet dispensing, printing, taste masking, water insoluble drugs

Scoutaris, Nikolaos, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Taste masked thin films printed by jet dispensing. International Journal of Pharmaceutics, 494 (2). pp. 619-622. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2015.05.018)

lipid micelles, single wall carbon nanotubes, Raman spectroscopy, atomic force microscopy, zeta potential

Tasis, Dimitrios, Papagelis, Konstantinos, Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Smith, James R., Bouropoulos, Nikolaos and Fatouros, Dimitrios G. (2008) Diameter-selective solubilization of carbon nanotubes by lipid micelles. Journal of Nanoscience and Nanotechnology, 8 (1). pp. 420-423. ISSN 1533-4880 (doi:https://doi.org/10.1166/jnn.2008.104)

liposomes, invasomes, fluidity, electron spin resonance, differential scanning calorimetry, temoporfin

Dragicevic-Curic, Nina, Friedrich, Manfred, Petersen, Silvia, Scheglmann, Dietrich, Douroumis, Dennis ORCID: 0000-0002-3782-0091 , Plass, Winfried and Fahr, Alfred (2011) Assessment of fluidity of different invasomes by electron spin resonance and differential scanning calorimetry. International Journal of Pharmaceutics, 412 (1-2). pp. 85-94. ISSN 0378-5173

matrix tablets, direct compression, sustained release, higuchi model, diltiazem hydrochloride, drug stability, tablets

Boyapally, Harikrishna, Nukala, Ravi Kumar and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2009) Development and release mechanism of diltiazem HCl prolonged release matrix tablets. Drug Delivery, 16 (2). pp. 67-74. ISSN 1071-7544 (doi:https://doi.org/10.1080/10717540802586220)

mesoporous silica, functionalized silica nanoparticles, cellular uptake, toxicity, drug delivery, imaging

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Onyesom, Ichioma, Maniruzzaman, Mohammed and Edwards, Mark (2011) Mesoporous silica nanoparticles as a drug delivery system. In: Vivero-Escoto, Juan, (ed.) Silica Nanoparticles: Preparation, Properties and Uses. Nanotechnology Science and Technology Series. Chemical Engineering Methods and Technology Series . Nova Science Publishers, Hauppauge, NY, USA, pp. 81-114. ISBN 978-1-61324-452-4

mesoporous silica, sba-16, antiepileptic drugs, loading, cytotoxicity

Thomas, M.J.K., Slipper, I., Walunj, A., Jain, A., Favretto, M.E., Kallinteri, P. and Douroumis, Di. ORCID: 0000-0002-3782-0091 (2009) Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. International Journal of Pharmaceutics, 387 (1-2). pp. 272-277. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2009.12.023)

microneedles; 3D printing; stereolithography; optimisation; inkjet coating

Economidou, Sophia, Pissinato Pere, Cristiane, Okereke, Michael ORCID: 0000-0002-2104-012X and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2021) Optimisation of design and manufacturing parameters of 3D printed solid microneedles for improved strength, sharpness, and drug delivery. Micromachines, 12 (2). ISSN 2072-666X (doi:https://doi.org/10.3390/mi12020117)

mixing, mathematical model, liposomes, polymeric drug delivery systems, nanoparticles

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Scheler, Stefan and Fahr, Alfred (2008) Using a modified shepards method for optimization of a nanoparticulate cyclosporine a formulation prepared by a static mixer technique. Journal of Pharmaceutical Sciences, 97 (2). pp. 919-930. ISSN 0022-3549 1520-6017 (online) (doi:https://doi.org/10.1002/jps.21001)

nanoparticles, mesoporous silica, supercritical fluids, drug solubility, loading, cytotoxicity

Patil, A., Chirmade, U. N., Trivedi, V. ORCID: 0000-0001-9304-9214 , Lamprou, D.A., Urquart, A. and Douroumis, D. ORCID: 0000-0002-3782-0091 (2011) Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide. Journal of Nanomedicine and Nanotechnology, 2 (3). ISSN 2157-7439 (doi:https://doi.org/10.4172/2157-7439.1000111)

polymorph spectroscopy

Moradiya, Hiren, Islam, Muhammad T., Woollam, Grahame R., Slipper, Ian J., Halsey, Sheelagh, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2013) Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. Crystal Growth & Design, 14 (1). pp. 189-198. ISSN 1528-7483 (Print), 1528-7505 (Online) (doi:https://doi.org/10.1021/cg401375a)

polymorphs, transformation, variable-temperature XRPD, caprolactam, extrudates, near-infrared spectroscopy, Polynorphism, drug delivery, crystals

Maniruzzaman, Mohammed, Islam, Muhammad T., Moradiya, Hiren G., Halsey, Sheelagh A., Slipper, Ian J., Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2014) Prediction of polymorphic transformations of paracetamol in solid dispersions. Journal of Pharmaceutical Sciences, 103 (6). pp. 1819-1828. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:https://doi.org/10.1002/jps.23992)

prostate cancer, bioconjugated quantum dots

Rajaram, Sudha, Bhujbal, Pranav, Slipper, Ian J., Favretto, Marco E. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) Prostate cancer targeting with 7E11-C5.3-CdS bioconjugated quantum dots. Journal of Colloid Science and Biotechnology, 2 (1). pp. 34-39. ISSN 2164-9634 (Print), 2164-9642 (Online) (doi:https://doi.org/10.1166/jcsb.2013.1036)

quantum dot, nanoparticles, bioconjugation, molecular imaging, targeting

Obonyo, Onyechi, Fisher, Emma, Edwards, Mark and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2010) Quantum dots synthesis and biological applications as imaging and drug delivery systems. Critical Reviews in Biotechnology, 30 (4). pp. 283-301. ISSN 0738-8551 (Print), 1549-7801 (Online) (doi:https://doi.org/10.3109/07388551.2010.487184)

solid dispersions, cationic drugs, anionic polymers, hot-melt extrusion (HME) technique

Maniruzzaman, Mohammed, Morgan, David J., Mendham, Andrew P., Pang, Jiayun ORCID: 0000-0003-0689-8440 , Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) Drug–polymer intermolecular interactions in hot-melt extruded solid dispersions. International Journal of Pharmaceutics, 443 (1-2). pp. 199-208. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2012.11.048)

solid dispersions, quantum mechanics, molecular modelling, miscibility, drug-polymer interactions

Maniruzzaman, Mohammed, Pang, Jiayun ORCID: 0000-0003-0689-8440 , Morgan, David J. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Molecular modelling as a predictive tool for the development of solid dispersions. Molecular Pharmaceutics, 12 (4). pp. 1040-1049. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/mp500510m)

solid lipid nanoparticles (SLNs); prostate cancer therapy

Akanda, Mushfiq, Getti, Giulia ORCID: 0000-0003-1402-8496 , Nandi, Uttom, Sadeque Mithu, Md and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2021) Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. International Journal of Pharmaceutics, 599:120416. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2021.120416)

solid lipid nanoparticles, high pressure homogenization, cyclosporine, cytotoxicity

Potta, Sriharsha Gupta, Minemi, Sriharsha, Nukala, Ravi Kumar, Peinado, Chairmane, Lamprou, Dimitrios A., Urquhart, Andrew and Douroumis, D. ORCID: 0000-0002-3782-0091 (2010) Development of solid lipid nanoparticles for enhanced solubility of poorly soluble drugs. Journal of Biomedical Nanotechnology, 6 (6). pp. 634-640. ISSN 1550-7033 (Print), 1550-7041 (Online) (doi:https://doi.org/10.1166/jbn.2010.1169)

solid lipid nanoparticles; curcumin; transferrin; prostate cancer; bioconjugation

Akanda, Md Mushfiq, Getti, Giulia ORCID: 0000-0003-1402-8496 , Nandi, Uttom, Mithu, Md Sadeque Hossain and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2021) Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. International Journal of Pharmaceutics, 599:120416. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2021.120416)

solid-state thermomechanical extrusion process, pharmaceutical salts

Mithu, Sadeque Hossain, Ross, Steven A., Alexander, Bruce D. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2019) Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing. Green Chemistry, 22 (2). pp. 540-549. ISSN 1463-9262 (Print), 1463-9270 (Online) (doi:https://doi.org/10.1039/C9GC03528A)

spray-drying, nanoparticles, microparticles, biodegradable polymers, encapsulation

Schafroth, Nina, Arpagaus, Cordin, Jadhava, Umesh Y., Makne, Sushil and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids and Surfaces B: Biointerfaces, 90 (1). pp. 8-15. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2011.09.038)

stealth liposomes, sirolimus, mechanical properties, atomic force microscopy, X-ray photon electron analysis

Onyesom, Ichioma, Lamprou, Dimitrios A., Sygellou, Lamprini, Owusu-Ware, Samuel K., Antonijevic, Milan ORCID: 0000-0002-5847-7886 , Chowdhry, Babur Z. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) Sirolimus encapsulated liposomes for cancer therapy: physicochemical and mechanical characterization of sirolimus distribution within liposome bilayers. Molecular Pharmaceutics, 10 (11). pp. 4281-4293. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/mp400362v)

stent coating strategies, plasma coating, spray coating, jet coating

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 and Onyesom, Ichioma (2011) Novel coating technologies of drug-eluting stents. In: Zilberman, Meital, (ed.) Biomaterials and Nanostructures for Active Implants. Studies in mechanobiology, tissue engineering and biomaterials, 8 . Springer, London, UK, pp. 87-125. ISBN 9783642180651

taste masking, fast dissolving tablets, inclusion complexation, microencapsulation, solid dispersions

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2007) Practical approaches of taste masking technologies in oral solid forms (Review). Expert Opinion on Drug Delivery, 4 (4). pp. 417-426. ISSN 1742-5247 (Print), 1744-7593 (Online) (doi:https://doi.org/10.1517/17425247.4.4.417)

taste-masking, oral disintegrating tablets, fluidized-bed coating, superdisintegrants

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Gryczke, Andreas and Schminke, Silke (2011) Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets. AAPS PharmSci Tech, 12 (1). pp. 141-151. ISSN 1530-9932 (Online) (doi:https://doi.org/10.1208/s12249-010-9569-7)

three‐dimensional printing; fused deposition modeling; inkjet printing; polyvinylalcohol; minoxidil; dissolution

Junqueira, Laura Andrade, Ghanizadeh Tabriz, Atabak, Raposo, Francisco José, Carobini, Luana Rocha, Vaz, Urias Pardócimo, Brandão, Marcos Antônio Fernandes, Douroumis, Dionysios ORCID: 0000-0002-3782-0091 and Raposo, Nádia Rezende Barbosa (2022) Coupling of fused deposition modeling and inkjet printing to produce drug loaded 3D printed tablets. Pharmaceutics, 14 (1):159. ISSN 1999-4923 (Online) (doi:https://doi.org/10.3390/pharmaceutics14010159)

water insoluble drugs, nanoparticles, liposomes, hydrosols, dendrimers, polymers, solid dispersions

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 and Fahr, Alfred (eds.) (2013) Drug delivery strategies for poorly water-soluble drugs. Advances in Pharmaceutical Technology . Wiley. ISBN 9780470711972