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Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals

Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals

Nadarassan, D. K., Loni, A., Q. Shabir, Q., Kelly, C, O’Brien, H., Caffull, E., Webb, K., Canham, L. T., Maniruzamman, M, Trivedi, V. ORCID: 0000-0001-9304-9214 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2015) Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals. In: Controlled Release Society Meeting. CRS, pp. 42-43.

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Biodegradable porous silicon (pSi) is under assessment for the controlled release of both proteins and poorly-soluble API formulations. Super-critical drying of ultrahigh porosity (90%) porous silicon is shown here to preserve much higher mesopore volumes (up to 4mL/g) and surface areas (up to 600m2M/g) than achievable with standardair drying. The payloads and physical state of the model drug (S) (+) ibuprofen, as loaded within a super-critically dried porous silicon carrier matrix,were quantified and assessed using TGA, DSC, cross-sectional EDX, XRD, Raman mapping andFT-IR. In-vitro biodegradability was assessed using Mmolybdenum blue assay and drug release using RPHPLC. Entrapped drug payloads as high as 70%w/w have been achieved, substantially higher than values reported for other mesoporous materials. The entrapped (S) (+) ibuprofen showed faster release than bulk (S) (+) ibuprofen.

Item Type: Conference Proceedings
Title of Proceedings: Controlled Release Society Meeting
Uncontrolled Keywords: Ultrahigh Drug Loading, Biodegradable Porous Silicon, Aerocrystals, supercritical CO2
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 19 May 2019 09:17
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None

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