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Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

Mithu, Sadeque Hossain, Ross, Steven A., Alexander, Bruce D. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2019) Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing. Green Chemistry, 22 (2). pp. 540-549. ISSN 1463-9262 (Print), 1463-9270 (Online) (doi:https://doi.org/10.1039/C9GC03528A)

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Abstract

Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole - oxalic acid and ciprofloxacin – maleic acid salts by imparting temperature, shear rate and stress in comparison to liquid assisted grinding (LAG) approach. We demonstrated that thermomechanical synthesis is advantageous by producing high quality and pure, solvent-free pharmaceutical salts by tailoring extrusion processing variables.

Item Type: Article
Uncontrolled Keywords: solid-state thermomechanical extrusion process, pharmaceutical salts
Subjects: Q Science > Q Science (General)
T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Centre for Innovation and Process Engineering in Research (CIPER)
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 31 Jan 2020 11:41
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/26070

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