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Hot-Melt Extrusion: pharmaceutical applications

Hot-Melt Extrusion: pharmaceutical applications

Douroumis, Dennis ORCID: 0000-0002-3782-0091 (ed.) (2012) Hot-Melt Extrusion: pharmaceutical applications. Advances in Pharmaceutical Technology . John Wiley & Sons, Ltd., Chichester, UK. ISBN 9780470711187

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Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets.

Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include:

•principles and die design of single screw extrusion
•twin screw extrusion techniques and practices in the laboratory and on production scale
•HME developments for the pharmaceutical industry
•solubility parameters for prediction of drug/polymer miscibility in HME formulations
•the influence of plasticizers in HME
•applications of polymethacrylate polymers in HME
•HME of ethylcellulose, hypromellose, and polyethylene oxide
•bioadhesion properties of polymeric films produced by HME
•taste masking using HME
•clinical studies, bioavailability and pharmacokinetics of HME products
•injection moulding and HME processing for pharmaceutical materials
•laminar dispersive & distributive mixing with dissolution and applications to HME

Item Type: Edited Book
Additional Information: E-book ISBN: 9781118307878
Uncontrolled Keywords: Hot melt extrusion, polymers, medical devices, solubility parameters, scale-up
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
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Last Modified: 19 May 2019 09:17

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