Palmer, Dasha, Levina, Marina, Nokhodchi, Ali, Douroumis, Dennis ORCID: 0000-0002-3782-0091, Farrell, Tom and Rajabi-Siahboomi, Ali (2011) The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices. AAPS PharmSci Tech, 12 (3). pp. 862-871. ISSN 1530-9932 (Online) (doi:https://doi.org/10.1208/s12249-011-9648-4)

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Abstract

Anionic polymer sodium carboxymethylcellulose (CELLOGEN® HP-HS and/or HP-12HS)was investigated for its ability to influence the release of three model drugs propranolol hydrochloride, theophylline and ibuprofen from polyethylene oxide (POLYOX™ WSR 1105 and/or Coagulant) hydrophilic matrices. For anionic ibuprofen and non-ionic theophylline, no unusual/unexpected release profiles were obtained from tablets containing a mixture of two polymers. However, for cationic propranolol HCl, a combination of polyethylene oxide (PEO) with sodium carboxymethylcellulose (NaCMC) produced a significantly slower drug release compared to the matrices with single polymers. The potential use of this synergistic interaction can be a design of new extended release pharmaceutical dosage forms with a more prolonged release (beyond 12 h) using lower polymer amount, which could be particularly beneficial for freely water-soluble drugs, preferably for once daily oral administration. In order to explain changes in the obtained drug release profiles, Fourier transform infrared absorption spectroscopy was performed. A possible explanation for the more prolonged propranolol HCl release from matrices based on both PEO and NaCMC may be due to a chemical bond(i.e. ionic/electrostatic intermolecular interaction) between amine group of the cationic drug and carboxyl group of the anionic polymer, leading to a formation of a new type/form of the active (i.e. salt) with sustained release pattern.

Item Type:	Article
Uncontrolled Keywords:	extended release, FT-IR, ibuprofen, matrix tablet, polyethylene oxide, polymer combination, propranolol hydrochloride, sodium carboxymethylcellulose, theophylline
Subjects:	Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Publisher
Last Modified:	19 May 2019 09:17
URI:	http://gala.gre.ac.uk/id/eprint/7420

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