AbetaPP; Alzheimer’s disease; Differentiation; SH-SY5Y; Super-resolution microscopy

Riegerova, Petra, Brejcha, Jundrich, Bezdekova, Dagmar, Chum, Tomas, Masinova, Eva, Cermakova, Nikola, Ovsepian, Saak, Cebecauer, Marek and Stefl, Marek (2021) Expression and localization of AβPP in SH-SY5Y cells depends on differentiation state. Journal of Alzheimer's Disease, 82. pp. 485-491. ISSN 2542-4823 (Online) (doi:https://doi.org/10.3233/JAD-201409)

ChIP; HLA; PARTICLE; TINA; histone; long non-coding RNA; methylation

Juříčková, Iva, Hudec, Michael, Votava, Felix, Vosáhlo, Jan, Ovsepian, Saak, Černá, Marie and O'Leary, Valerie (2022) The immunological epigenetic landscape of the human life trajectory. Biomedicines, 10 (11):2894. ISSN 2227-9059 (Online) (doi:https://doi.org/10.3390/biomedicines10112894)

Eker rats; animal models of autism; cingulate gyrus; enriched environment; open field test; tuberous sclerosis complex, dendritic spine.

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:https://doi.org/10.1111/ejn.15864)

GluN1 subunit; autoimmune response; endocannabinoids; endogenous polyamines; kynurenic acid; neurosteroids; zinc

Jorratt, Pascal, Hoschl, Cyril and Ovsepian, Saak (2021) Endogenous antagonists of N-Methyl-D-Aspartate receptor in schizophrenia. Alzheimers and Dementia, 17 (5). pp. 888-905. ISSN 1552-5279 (Print), 1552-5279 (Online) (doi:https://doi.org/10.1002/alz.12244)

Growth factor; neuropsychiatry; antidepressants; antipsychotics; targeted delivery; polyplex nanoparticles

Dremencov, Eliyahu ORCID: 0000-0001-8103-8577 , Jezova, Daniela, Barak, Segev ORCID: 0000-0002-3143-6777 , Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:https://doi.org/10.1016/j.neulet.2021.136194)

TrkB receptor; estradiol; fluid biomarker; neuroplasticity; perinatal affective disorder; postpartum depression; pregnancy

Singh, Saumya, Fereshetyan, Katarine, Shorter, Susan, Paliokha, Ruslan, Dremencov, Eliyahu, Yenkoyan, Konstantin and Ovsepian, Saak (2022) Brain-derived neurotrophic factor (BDNF) in perinatal depression: side show or pivotal factor? Drug Discovery Today, 28 (2):103467. pp. 1-7. ISSN 1359-6446 (doi:https://doi.org/10.1016/j.drudis.2022.103467)

adult neurogenesis; autoimmunity; biomarkers; enteric nervous system; neurodegenerative disease; tau

Ovsepian, Saak and O'Leary, Valerie (2022) Adult neurogenesis in the gut, homeostatic autoimmunity and neurodegenerative disease biomarkers. Neuroscience, 10 (504). pp. 75-78. ISSN 0306-4522 (doi:https://doi.org/10.1016/j.neuroscience.2022.09.019)

advanced biomaterials; animal toxins; fluorescent probes; ICG; Ion channels; optical imaging; visualisation

Ergen, Pinar Helin, Shorter, Susan, Ntizachristos, Vasilis and Ovsepian, Saak (2023) Neurotoxin-derived optical probes for biological and medical imaging. Molecular Imaging and Biology, 25. pp. 799-814. ISSN 1536-1632 (Print), 1860-2002 (Online) (doi:https://doi.org/10.1007/s11307-023-01838-1)

artificial intelligence, machine learning, anticancer therapy, patient profiling, migraine, personalized medicine, predictive modeling

Olawade, David B., Teke, Jennifer, Adeleye, Khadijat K., Egbon, Eghosasere, Weerasinghe, Kusal, Ovsepian, Saak V. and Boussios, Stergios (2024) AI-guided cancer therapy for patients with coexisting migraines. Cancers, 16 (21):3690. ISSN 2072-6694 (Online) (doi:https://doi.org/10.3390/cancers16213690)

autism spectrum disorder; cerebellum; mTORC1 signaling; demyelination; Purkinje neurons; microglia activation; synaptophysin

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:https://doi.org/10.1002/aur.2688)

axonal degeneration; epileptic seizures; fluid biomarkers; neurodegeneration; neurofilament light chain; neurogranin; Tau protein

Negi, Deepika, Granak, Simon, Shorter, Susan, O’Leary, Valerie B., Rekto, Ivan and Ovsepian, Saak (2023) Molecular biomarkers of neuronal injury in epilepsy shared with neurodegenerative diseases. Neurotherapeutics. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:https://doi.org/10.1007/s13311-023-01355-7)

brain evolution; cholinergic neurons; p75 NTR; amyloid deposition; cortical expansion; default mode networks; Alzheimer’s disease

Ovsepian, Saak, O'Leary, Valerie, Hoschl, Cyril and Zaborszky, Laszlo (2021) Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: a unifying hypothesis. Neuroscience Letters, 11 (755):135895. pp. 1-9. ISSN 0304-3940 (Print), 0304-3940 (Online) (doi:https://doi.org/10.1016/j.neulet.2021.135895)

brain; placenta; microbiome; mental health

Ovsepian, Saak, O'Leary, Valerie and Hoschl, Cyril (2021) Mainstream psychiatry reinstates therapeutic ventures of the remote past. Drug Discovery Today, 26 (3). pp. 845-851. ISSN 1359-6446 (Print), 1359-6446 (Online) (doi:https://doi.org/10.1016/j.drudis.2021.01.011)

bulbar and spinal ALS; excitotoxicity; motor neuron disease; motor units; SOD1 mutation; skeletal and visceral muscles; TDP43

Ovsepian, Saak, O'Leary, Valerie B and Martinez, Salvador (2023) Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates. Brain Structure and Function. ISSN 1863-2653 (Print), 1863-2661 (Online) (doi:https://doi.org/10.1007/s00429-023-02728-6)

chromosome, lncRNA, CD54, prominin-1, ATRA, brain cancer

Pokorná, Markéta, Hudec, Michael, Juříčková, Iva, Michael, Vácha, Zdeňka, Polívková, Viera, Kútna, Jan, Pala, Ovsepian, Saak V., Marie, Černá and Valerie Bríd, O'Leary (2021) All-trans retinoic acid fosters the multifarious U87MG cell line as a model of glioblastoma. Brain Sciences, 11 (6):812. ISSN 2076-3425 (Online) (doi:https://doi.org/10.3390/brainsci11060812)

chronic pain; nociception; sensory neurons; gene therapy

Ovsepian, Saak and Waxman, Stephen (2023) Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors. Nature Review Neuroscience, 12 (1):1. pp. 252-265. ISSN 1471-003X (Print), 1471-0048 (Online) (doi:https://doi.org/10.1038/s41583-022-00673-7)

cortical thinning; dendritic morphology; glutamate release; intrinsic excitability; neuroplasticity; neurosteroids; polyamines; psd95

Jorratt, Pascal, Ricny, Jan, Leibold, Christian and Ovsepian, Saak (2022) Endogenous modulators of NMDA receptor control dendritic field expansion of cortical neurons. Molecular Neurobiology. ISSN 0893-7648 (Print), 1559-1182 (Online) (doi:https://doi.org/10.1007/s12035-022-03147-0)

epilepsy; medicinal herbs; biomarkers; antiseizure medications; Ion channels; mTOR signaling; neuroprotection

Tabassum, Sobia, Shorter, Susan and Ovsepian, Saak V. (2024) Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy. Journal of Molecular Medicine, 102. pp. 761-771. ISSN 0946-2716 (Print), 1432-1440 (Online) (doi:https://doi.org/10.1007/s00109-024-02445-5)

exosome; major histocompatibility complex II; autoimmunity; monocyte-derived dendritic cells; gluten

Hudec, Michael, Jurícková, Iva, Riegerová, Kamila, Ovsepian, Saak, Cerná, Marie and O’Leary, Valerie (2022) Enhanced extracellular transfer of HLA-DQ activates CD3+ lymphocytes towards compromised Treg induction in celiac disease. International Journal of Molecular Sciences, 23 (11):6102. ISSN 1661-6596 (doi:https://doi.org/10.3390/ijms23116102)

exosomes; renal cancer; tumor microenvironment; extracellular vesicles; biomarker

Ovsepian, Saak V. and Boussios, Stergios (2024) Exosomes in renal cell cancer: diagnostic and therapeutic nanovehicles (editorial). Technology in Cancer Research and Treatment, 23. pp. 1-4. ISSN 1533-0346 (Print), 1533-0338 (Online) (doi:https://doi.org/10.1177/15330338241275403)

fluid biomarkers, autoimmunity, dementia, differential diagnosis, immunoglobins

Kocurova, Gabriela, Ricny, Jan and Ovsepian, Saak (2022) Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases. Theranostics, 12 (7). pp. 3045-3056. ISSN 1838-7640 (Online) (doi:https://doi.org/10.7150/thno.72126)

lncRNA; noncoding RNA; glioblastoma multiforme; glioma; plasma; serum; blood; biomarker; liquid biopsy; AC016405.3; ADAMTs9-AS2; AGAP2-AS1; AHIF; ANRIL; lncRNA-ATB; CASC2; CASC7; CASC9; CCND2-AS1; CRNDE; DCST1-AS1; DGCR5; DLEU1-AS1; ECONEXIN; LINC00461; FAM66C; GAS5; H19; HMMR-AS1; HOTAIR; HOTAIRM1; HOXA-AS2; HOXB13-1; HOTTIP; HULC; KTN1-AS1; LINC00467; LINC00565; LINC00641; LINC01393; LINC01426; LINC01446; LINC01494; LINC01503; LINC01711; LINC02283; LINC-ROR; lnc-TALC; MAFG-DT; MALAT1; MATN1-AS1; MDC1-AS; MEG3; MIAT; MIR210HG; MNX1-AS1; NCK1-AS1; NEAT1; PART1; PARTICLE; PCAT1; PCA1; PVT1; RBPMS-AS1; RPSAP52; RUNX1-IT1; SAMMSON; SOX2-OT; TALNEC2; TP73-AS1; TSLC1-AS1; TUSC7; TUG1; TUNAR; UCA1; XIST; ZEB1-AS1; ZBED3-AS1

Pokorná, Markéta, Cern, Marie, Boussios, Stergios, Ovsepian, Saak V. and Bríd O’Leary, Valerie (2024) lncRNA biomarkers of glioblastoma multiforme. Biomedicines, 12:932. pp. 1-37. ISSN 2227-9059 (Online) (doi:https://doi.org/10.3390/biomedicines12050932)

mTOR signalling; autism spectrum disorders; hamartoma; neoplasia; TSC1; TSC2; refractory epilepsy

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:https://doi.org/10.1007/s13311-020-01000-7)

methamphetamine, sleep and insomnia, dopamine, addiction, modafinil, drug abuse, circadian rhythms, dopamine transporter

Vrajova, Monika, Slamberova, Romana, Hoschl, Cyril and Ovsepian, Saak (2021) Methamphetamine and sleep impairments: neurobehavioral correlates and molecular mechanisms. Sleep, 44 (6):zsab001. ISSN 0161-8105 (Print), 1550-9109 (Online) (doi:https://doi.org/10.1093/sleep/zsab001)

neuroplasticity; general anesthesia; dendritic spine dynamics; coflin; actin cytoskeleton; depression

Granak, Simon, Hoschl, Cyril and Ovsepian, Saak V. (2021) Dendritic spine remodeling and plasticity under general anaesthesia. Brain Structure and Function, 226. pp. 2001-2017. ISSN 1863-2653 (Print), 1863-2661 (Online) (doi:https://doi.org/10.1007/s00429-021-02308-6)

neuroprotection; oestrogen; hormone replacement therapy; healthy ageing; contraception; gender transition; transgender; cognitive decline

Zhang, Grace, Devo, Perry ORCID: 0000-0003-1487-8896 , O'Leary, Valerie B. ORCID: 0000-0003-1171-9830 and Ovsepian, Saak ORCID: 0000-0002-9522-4159 (2023) Ageing perspective on cognitive outcomes from auxiliary reproductive hormone adjustments. Heliyon, 9 (8):E19050. pp. 1-7. ISSN 2405-8440 (Online) (doi:https://doi.org/10.1016/j.heliyon.2023.e19050)

Zhang, Grace, Devo, Perry, O'Leary, Valerie and Ovsepian, Saak (2023) Ageing perspective on cognitive outcomes from reproductive hormone adjustments. Heliyon, 9 (8):E19050. pp. 1-7. ISSN 2405-8440 (Online) (doi:https://doi.org/10.1016/j.heliyon.2023.e19050)

neuroprotection; plasticity; adjuvant therapy; menopause; cognitive deficit; animal models

Androvičová, Renáta, Pfaus, James G and Ovsepian, Saak (2021) Oestrogen pendulum in schizophrenia and Alzheimer's disease: review of therapeutic benefits and outstanding questions. Neuroscience Letters, 759:136038. pp. 1-8. ISSN 0304-3940 (Print), 0304-3940 (Online) (doi:https://doi.org/10.1016/j.neulet.2021.136038)

prominin-1; ICAM-1; lncRNA; Glioma; Eker rats; U87MG; PARTICLE; GAS5; GBM; biomarker

Pokorná, Markéta, Kútna, Viera, Ovsepian, Saak V., Matěj, Radoslav, Cerná, Marie and Brid O'Leary, Valerie (2024) Biomolecules to biomarkers? U87MG marker evaluation on the path towards glioblastoma multiforme pathogenesis. Pharmaceutics, 16 (1):123. pp. 1-16. ISSN 1999-4923 (Print), 12 January 2024 / Published: 18 January 2024 (Online) (doi:https://doi.org/10.3390/pharmaceutics16010123)

renal cell cancer; exosomes; tumor microenvironment; mRNA; miRNA; tumor drug resistance

Boussios, Stergios, Devo, Perry, Rassy, Elie and Ovsepian, Saak (2023) Exosomes in the diagnosis and treatment of renal cell cancer. International Journal of Molecular Sciences, 24 (18):14356. pp. 1-23. ISSN 1661-6596 (Print), 1422-0067 (Online) (doi:https://doi.org/10.3390/ijms241814356)

steroid hormones, UHPLC-MS, solid phase extraction, supercritical fluid, biomarkers, UHPSFC-MS

Devo, Perry, Cretu, Victoria, Radhakrishnan, Harsha, Hamilton-Pink, Darren, Boussios, Stergios and Ovsepian, Saak V. (2024) An orthogonal approach for analysis of underivatized steroid hormones using ultrahigh performance supercritical fluid chromatography-mass spectrometry. Journal of Neural Transmission. ISSN 0300-9564 (Print), 1435-1463 (Online) (doi:https://doi.org/10.1007/s00702-024-02862-3)