AMPA receptor; PKA; STIM1 and STIM2; endoplasmic reticulum; excitatory synapse; long-term potentiation; spatial memory

Garcia-Alvarez, Gisela, Shetty, Mahesh S., Lu, Bo, Yap, Kenrick An Fu, Oh-Hora, Masatsugu, Sajikumar, Sreedharan, Bichler, Zoë and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2015) Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes. Frontiers in Behavioral Neuroscience, 9:180. ISSN 1662-5153 (Online) (doi:https://doi.org/10.3389/fnbeh.2015.00180)

AMPA receptors, Endoplasmic reticulum, Synaptic plasticity, Stim2, Trafficking

Garcia-Alvarez, Gisela, Lu, Bo, Yap, Kenrick An Fu, Wong, Loo Chin, Thevathasan, Jervis Vermal, Lim, Lynette, Ji, Fang, Tan, Kia Wee, Mancuso, James J., Tang, Willcyn, Poon, Shou Yu, Augustine, Goerge J. and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2015) STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs. Molecular Biology of the Cell, 26 (6). pp. 1141-1159. ISSN 1059-1524 (Print), 1939-4586 (Online) (doi:https://doi.org/10.1091/mbc.E14-07-1222)

Cell migration, Feedback loops, Self-assembly, Signalling, Chemical genetics

Thevathasan, Jervis Vermal, Tan, Elisabeth, Zheng, Hui, Lin, Yu-Chun, Li, Yang, Inoue, Takanari and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2013) The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts. Molecular Biology of the Cell, 24 (14). pp. 2228-2237. ISSN 1059-1524 (Print), 1939-4586 (Online) (doi:https://doi.org/10.1091/mbc.E12-12-0905)

Endoplasmic reticulum; Excitatory synapse; Plasticity; Memory; Long-term potentiation; Long-term depression; AMPA receptors

Yap, Kenrick An Fu, Shetty, Mahesh Shivarama, Garcia-Alvarez, Gisela, Lu, Bo, Alagappan, Durgadevi, Oh-Hora, Masatsugu, Sajikumar, Sreedharan and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2016) STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Neurobiology of Learning and Memory, 138. pp. 54-61. ISSN 1074-7427 (doi:https://doi.org/10.1016/j.nlm.2016.08.007)

Image processing; microRNA (miRNA); Presynaptic terminals; Primary neuron culture; Synapse formation; Synaptic vesicles; Synaptogenic proteins

Poon, Vivian Y., Goh, Chiatzun, Voorhoeve, P. Mathijs and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2014) High-content imaging of presynaptic assembly. Frontiers in Cellular Neuroscience, 8. ISSN 1662-5102 (Online) (doi:https://doi.org/10.3389/fncel.2014.00066)

Imaging, STIM, SOCE, Segmentation Software, Image analysis

Wong, Loo Chin, Lu, Bo, Tan, Kia Wee and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2010) Fully-automated image processing software to analyze calcium traces in populations of single cells. Cell calcium, 48 (5). pp. 270-4. ISSN 1532-1991 (doi:https://doi.org/10.1016/j.ceca.2010.09.008)

Integrin, Invasion, Lamellipodia, Migration

Astro, Veronica, Chiaretti, Sara, Magistrati, Elisa, Fivaz, Marc ORCID: 0000-0003-1003-7934 and de Curtis, Ivan (2014) Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration. Journal of Cell Science, 127 (17). pp. 3862-3876. ISSN 0021-9533 (Print), 1477-9137 (Online) (doi:https://doi.org/10.1242/jcs.155663)

Oncoproteins, Transformation, Hippo pathway, YAP proto-oncogene

Nguyen, Hung Thanh, Hong, Xin, Tan, Sam, Chen, Qingfeng, Chan, Lifang, Fivaz, Marc ORCID: 0000-0003-1003-7934 , Cohen, Stephen M. and Voorhoeve, P. Mathijs (2014) Viral small T oncoproteins transform cells by alleviating hippo-pathway-mediated inhibition of the YAP proto-oncogene. Cell Reports, 8 (3). pp. 707-713. ISSN 2211-1247 (Print), 2211-1247 (Online) (doi:https://doi.org/10.1016/j.celrep.2014.06.062)

SOCE, STIM, neuron, calcium imaging, endoplasmic reticulum

Lu, Bo and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2016) Neuronal SOCE: myth or reality? Trends in Cell Biology, 26 (12). pp. 890-893. ISSN 0962-8924 (Print), 1879-3088 (Online) (doi:https://doi.org/10.1016/j.tcb.2016.09.008)

Synapse, Imaging, Fluorescent biosensors, Optogenetics

Augustine, George J. and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2016) Editorial: Imaging synapse structure and function. Frontiers in Synaptic Neuroscience, 8:36. ISSN 1663-3563 (Online) (doi:https://doi.org/10.3389/fnsyn.2016.00036)

autism; human neural progenitors; stem cells; CHD8

Coakley-Youngs, Emma, Ranatunga, Medhavi, Richardson, Simon ORCID: 0000-0002-7927-0649 , Getti, Giulia ORCID: 0000-0003-1402-8496 , Shorter, Susan and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2022) Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle. Biology Open, 11 (9):bio058941. pp. 1-11. ISSN 2046-6390 (Online) (doi:https://doi.org/10.1242/bio.058941)

feedback, signalling, Ras, PI3K, neuron, differentiation

Fivaz, Marc ORCID: 0000-0003-1003-7934 , Bandara, Samuel, Inoue, Takanari and Meyer, Tobias (2007) Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Current Biology, 18 (1). pp. 44-50. ISSN 0960-9822 (Print), 1879-0445 (Online) (doi:https://doi.org/10.1016/j.cub.2007.11.051)

feedback, signalling, synapse, neurobiology

Li, Yang and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2008) Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue. BioEssays : news and reviews in molecular, cellular and developmental biology, 30 (10). pp. 929-933. ISSN 1521-1878 (Print), 1475-147X (Online) (doi:https://doi.org/10.1002/bies.20824)

mammary cancer, metastatic sublines, syngeneic, spontaneous metastasis, D2A1, BALB/c

Jungwirth, Ute, van Weverwijk, Antoinette, Melake, Miriam J., Chambers, Ann F., Gao, Qiong, Fivaz, Marc ORCID: 0000-0003-1003-7934 and Isacke, Clare M. (2017) Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host. Disease models & mechanisms. ISSN 1754-8403 (Print), 1754-8411 (Online) (doi:https://doi.org/10.1242/dmm.031740)

miRNAs, Synapse, Transcriptome, Polycomb Group Protein, Neurotransmission, Epigenetics

Poon, Vivian Y., Gu, Minxia, Ji, Fang, VanDongen, Antonius M. and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2016) miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1. BMC Genomics, 17 (1):777. ISSN 1471-2164 (Online) (doi:https://doi.org/10.1186/s12864-016-3139-7)

synaptic vesicle cycle, neurotransmitter, synaptic transmission, DISC1, neuropsychiatric disorders

Tang, Willcyn, Thevathasan, Jervis Vermal, Lin, Qingshu, Lim, Kim Buay, Kuroda, Keisuke, Kaibuchi, Kozo, Bilger, Marcel, Soong, Tuck Wah and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2016) Stimulation of synaptic vesicle exocytosis by the mental disease gene DISC1 is mediated by N-Type voltage-gated calcium channels. Frontiers in Synaptic Neuroscience, 8:15. ISSN 1663-3563 (Online) (doi:https://doi.org/10.3389/fnsyn.2016.00015)