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Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration

Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration

Astro, Veronica, Chiaretti, Sara, Magistrati, Elisa, Fivaz, Marc ORCID: 0000-0003-1003-7934 and de Curtis, Ivan (2014) Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration. Journal of Cell Science, 127 (17). pp. 3862-3876. ISSN 0021-9533 (Print), 1477-9137 (Online) (doi:https://doi.org/10.1242/jcs.155663)

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Abstract

Cell migration during development and metastatic invasion requires the coordination of actin and adhesion dynamics to promote protrusive activity at the front of the cell. The knowledge of the molecular mechanisms required to achieve such coordination is fragmentary. Here, we identify a new functional complex that drives cell motility. ERC1a (an isoform of ERC1) and the LL5 proteins LL5α and LL5β (encoded by PHLDB1 and PHLDB2, respectively) are required, together with liprin-α1, for effective migration and tumor cell invasion, and do so by stabilizing the protrusive activity at the cell front. Depletion of either protein negatively affects invasion, migration on extracellular matrix, lamellipodial persistence and the internalization of active integrin β1 receptors needed for adhesion turnover at the front of the cell. Liprin-α1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge. Our results indicate that the functional complex and the associated structures described here represent an important mechanism to drive tumor cell migration.

Item Type: Article
Uncontrolled Keywords: Integrin, Invasion, Lamellipodia, Migration
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 28 Nov 2017 15:53
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/17890

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