Items where School / Department / Research Groups is "Medway School of Pharmacy"

2013

Ferrara, Francesca, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Corti, Davide, Scott, Simon D. and Temperton, Nigel J. (2013) The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7. pp. 309-314. ISSN 1747-0862

Mahallawi, Waleed H., Kasbekar, Anand V., McCormick, Maxwell S., Hoschler, Katja, Temperton, Nigel, Leong, Samuel C., Beer, Helen, Ferrara, Francesca, McNamara, Paul S. and Zhang, Qibo (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. ISSN 0022-538X (Print), 1098-5514 (Online) (In Press) (doi:10.1128/​JVI.03547-12)

Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862

Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)

2012

Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862

2011

Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)

Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)

Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)

Ibanez, Lorena Itati, De Filette, Marina, Hultberg, Anna, Verrips, Theo, Temperton, Nigel, Weiss, Robin A., Vandevelde, Wesley, Schepens, Bert, Vanlandschoot, Peter and Saelens, Xavier (2011) Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. The Journal of Infectious Diseases, 203 (8). pp. 1063-1072. ISSN 0022-1899 (print), 1537-6613 (on-line) (doi:10.1093/infdis/jiq168)

Loureiro, Silvia, Ren, Junyuan, Phapugrangkul, Pongsathon, Colaco, Camilo A., Bailey, Christopher R., Shelton, Holly, Molesti, Eleonora, Temperton, Nigel J., Barclay, Wendy S. and Jones, Ian M. (2011) Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. Journal of Virology, 85 (6). pp. 3010-3014. ISSN 0022-538X (Print), 1098-5514 (Online) (doi:10.1128/​JVI.01241-10)

Muthana, Munitta, Giannoudis, Athina, Scott, Simon D., Fang, Hsin-Yu, Coffelt, Seth B., Morrow, Fiona J., Murdoch, Craig, Burton, Julian, Cross, Neil, Burke, Bernard, Mistry, Roshna, Hamdy, Freddie, Brown, Nicola J., Georgopoulos, Lindsay, Hoskin, Peter, Essand, Magnus, Lewis, Claire E. and Maitland, Norman J. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71 (5). pp. 1805-1815. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-10-2349)

2010

Corti, Davide, Suguitan Jr., Amorsolo L., Pinna, Debora, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Vanzetta, Fabrizia, Santos, Celia, Luke, Catherine J., Torres-Velez, Fernando J., Temperton, Nigel J., Weiss, Robin A., Sallusto, Federica, Subbarao, Kanta and Lanzavecchia, Antonio (2010) Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. The Journal of Clinical Investigation, 120 (5). pp. 1663-1673. ISSN 0021-9738 (print), 1558-8238 (on-line) (doi:10.1172/JCI41902)

Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)

2009

Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)

Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)

Oha, Sawyin, Selleck, Paul, Temperton, Nigel J., Chan, Paul K.S., Capecchi, Barbara, Manavis, Jim, Higgins, Geoff, Burrell, Christopher J. and Kok, Tuckweng (2009) Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses. Journal of Virological Methods, 57 (2). pp. 161-167. ISSN 0166-0934 (doi:10.1016/j.jviromet.2008.12.016)

Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)

Temperton, Nigel (2009) Society of general microbiology - 2009 spring meeting. Idrugs: The Investigational Drugs Journal, 12 (5). pp. 294-296. ISSN 1369-7056 (print), 2040-3410 (online)

2008

Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.7)

Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)

Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)

Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)

Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.57)

Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)

Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)

2007

Dye, Charlotte, Temperton, Nigel and Siddell, Stuart G. (2007) Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. Journal of General Virology, 88 (6). pp. 1753-1760. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.82666-0)

Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)

Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)

2006

Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)

Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)

2005

Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)

Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)

Greco, O., Marples, B., Wilson, G.D., Joiner, M.C. and Scott, S.D. (2005) Radiation-induced gene therapy. Radiation Research, 163 (6). pp. 707-708. ISSN 0033-7587 (print), 1938-5404 (online) (doi:10.1667/RR3300)

Greco, Olga, Powell, Tanya M., Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2005) Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12 (7). pp. 655-662. ISSN 0929-1903 (print), 1476-5500 (on-line) (doi:10.1038/sj.cgt.7700834)

Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)

Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)

Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302552)

2004

Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)

Scott, Simon D. and Marples, Brian (2004) Radiation-activated antitumor vectors. In: Suicide Gene Therapy: methods and reviews. Methods in Molecular Medicine (90). Humana Press Inc., New Jersey, USA, pp. 389-402. ISBN 978-0-89603-971-1 (Print), 978-1-59259-429-0 (Online) ISSN 1543-1894 (doi:10.1385/1-59259-429-8:389)

2003

Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)

Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)

Temperton, Nigel J., Quenelle, Debra C., Lawson, Keirissa M., Zuckerman, Jane M., Kern, Earl R., Griffiths, Paul D. and Emery, Vincent C. (2003) Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. Journal of Medical Virology, 70 (1). pp. 86-90. ISSN 1096-9071 (on-line) (doi:10.1002/jmv.10357)

2002

Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)

Greco, O., Scott, S.D., Marples, B. and Dachs, D.U. (2002) Cancer gene therapy: 'delivery, delivery, delivery'. Frontiers in Bioscience, 7. d1516-d1524. ISSN 1093-9946 (print), 1093-4715 (on-line) (doi:10.2741/greco)

Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)

Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)

Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)

2001

Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)

Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)

2000

Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301116)

Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)

Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)

Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)

1998

Temperton, Nigel J., Wilkinson, Shane R., Meyer, David J. and Kelly, John M. (1998) Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Molecular and Biochemical Parasitology, 96 (1-2). pp. 167-176. ISSN 0166-6851 (doi:10.1016/S0166-6851(98)00127-3)

1996

Temperton, Nigel J., Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)