Items where School / Department / Research Groups is "Medway School of Pharmacy"
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2008
Oha, Sawyin, Selleck, Paul, Temperton, Nigel J., Chan, Paul K.S., Capecchi, Barbara, Manavis, Jim, Higgins, Geoff, Burrell, Christopher J. and Kok, Tuckweng (2009) Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses. Journal of Virological Methods, 57 (2). pp. 161-167. ISSN 0166-0934 (doi:10.1016/j.jviromet.2008.12.016)
[1] These data were presented at the 3rd ESWI conference
Oha, Sawyin, Selleck, Paul, Temperton, Nigel J., Chan, Paul K.S., Capecchi, Barbara, Manavis, Jim, Higgins, Geoff, Burrell, Christopher J. and Kok, Tuckweng (2009) Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses. Journal of Virological Methods, 57 (2). pp. 161-167. ISSN 0166-0934 (doi:10.1016/j.jviromet.2008.12.016)
adenovirus
Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)
Muthana, Munitta, Giannoudis, Athina, Scott, Simon D., Fang, Hsin-Yu, Coffelt, Seth B., Morrow, Fiona J., Murdoch, Craig, Burton, Julian, Cross, Neil, Burke, Bernard, Mistry, Roshna, Hamdy, Freddie, Brown, Nicola J., Georgopoulos, Lindsay, Hoskin, Peter, Essand, Magnus, Lewis, Claire E. and Maitland, Norman J. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71 (5). pp. 1805-1815. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-10-2349)
adjuvant
Temperton, Nigel J., Quenelle, Debra C., Lawson, Keirissa M., Zuckerman, Jane M., Kern, Earl R., Griffiths, Paul D. and Emery, Vincent C. (2003) Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. Journal of Medical Virology, 70 (1). pp. 86-90. ISSN 1096-9071 (on-line) (doi:10.1002/jmv.10357)
adriamycin
Greco, Olga, Powell, Tanya M., Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2005) Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12 (7). pp. 655-662. ISSN 0929-1903 (print), 1476-5500 (on-line) (doi:10.1038/sj.cgt.7700834)
Africa
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
anti-bacterial agents biosynthesis
Temperton, Nigel (2009) Society of general microbiology - 2009 spring meeting. Idrugs: The Investigational Drugs Journal, 12 (5). pp. 294-296. ISSN 1369-7056 (print), 2040-3410 (online)
anti-bacterial agents chemistry
Temperton, Nigel (2009) Society of general microbiology - 2009 spring meeting. Idrugs: The Investigational Drugs Journal, 12 (5). pp. 294-296. ISSN 1369-7056 (print), 2040-3410 (online)
anti-bacterial agents pharmacology
Temperton, Nigel (2009) Society of general microbiology - 2009 spring meeting. Idrugs: The Investigational Drugs Journal, 12 (5). pp. 294-296. ISSN 1369-7056 (print), 2040-3410 (online)
antibodies
Corti, Davide, Suguitan Jr., Amorsolo L., Pinna, Debora, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Vanzetta, Fabrizia, Santos, Celia, Luke, Catherine J., Torres-Velez, Fernando J., Temperton, Nigel J., Weiss, Robin A., Sallusto, Federica, Subbarao, Kanta and Lanzavecchia, Antonio (2010) Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. The Journal of Clinical Investigation, 120 (5). pp. 1663-1673. ISSN 0021-9738 (print), 1558-8238 (on-line) (doi:10.1172/JCI41902)
antibody
Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
antibody fragments
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
antibody response
Ferrara, Francesca, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Corti, Davide, Scott, Simon D. and Temperton, Nigel J. (2013) The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7. pp. 309-314. ISSN 1747-0862
antigenic drift
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
antiviral
Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)
autoimmune disease
Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)
avian H5N1 virus
Mahallawi, Waleed H., Kasbekar, Anand V., McCormick, Maxwell S., Hoschler, Katja, Temperton, Nigel, Leong, Samuel C., Beer, Helen, Ferrara, Francesca, McNamara, Paul S. and Zhang, Qibo (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. ISSN 0022-538X (Print), 1098-5514 (Online) (In Press) (doi:10.1128/JVI.03547-12)
avian influenza
Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)
avian influenza virus
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
bat
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
bioreductive drugs
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
birds
Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)
breast cancer
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
breast cancer xenografts
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
breast cell-specific expression targeting
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
bystander effect
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
cancer
Greco, O., Scott, S.D., Marples, B. and Dachs, D.U. (2002) Cancer gene therapy: 'delivery, delivery, delivery'. Frontiers in Bioscience, 7. d1516-d1524. ISSN 1093-9946 (print), 1093-4715 (on-line) (doi:10.2741/greco)
Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
cancer gene therapy
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302552)
CArG
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
CArG element
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
CArG elements
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301116)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302552)
cell-based
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.57)
cellular receptor
Dye, Charlotte, Temperton, Nigel and Siddell, Stuart G. (2007) Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. Journal of General Virology, 88 (6). pp. 1753-1760. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.82666-0)
chemotherapy
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
circular dichroism
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
CMV promoter
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
conformation
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
coronaviru
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
CoV
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
CpG ODN
Temperton, Nigel J., Quenelle, Debra C., Lawson, Keirissa M., Zuckerman, Jane M., Kern, Earl R., Griffiths, Paul D. and Emery, Vincent C. (2003) Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. Journal of Medical Virology, 70 (1). pp. 86-90. ISSN 1096-9071 (on-line) (doi:10.1002/jmv.10357)
CRE recombinase
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
Cre/lox recombination
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
Cre/loxP
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
cross-clade neutralization
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
cross-reactive immunity
Mahallawi, Waleed H., Kasbekar, Anand V., McCormick, Maxwell S., Hoschler, Katja, Temperton, Nigel, Leong, Samuel C., Beer, Helen, Ferrara, Francesca, McNamara, Paul S. and Zhang, Qibo (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. ISSN 0022-538X (Print), 1098-5514 (Online) (In Press) (doi:10.1128/JVI.03547-12)
CTL
Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)
cytomegalovirus
Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)
Temperton, Nigel J., Quenelle, Debra C., Lawson, Keirissa M., Zuckerman, Jane M., Kern, Earl R., Griffiths, Paul D. and Emery, Vincent C. (2003) Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. Journal of Medical Virology, 70 (1). pp. 86-90. ISSN 1096-9071 (on-line) (doi:10.1002/jmv.10357)
cytoplasmic peroxiredoxin
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
dipeptide isosteres
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
disease outbreaks
Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)
disordered
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
DNA
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
DNA repair
Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)
DNA vaccine
Temperton, Nigel J., Quenelle, Debra C., Lawson, Keirissa M., Zuckerman, Jane M., Kern, Earl R., Griffiths, Paul D. and Emery, Vincent C. (2003) Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. Journal of Medical Virology, 70 (1). pp. 86-90. ISSN 1096-9071 (on-line) (doi:10.1002/jmv.10357)
DNA vaccines
Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)
double-strand breaks
Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)
drug design
Temperton, Nigel (2009) Society of general microbiology - 2009 spring meeting. Idrugs: The Investigational Drugs Journal, 12 (5). pp. 294-296. ISSN 1369-7056 (print), 2040-3410 (online)
drug resistance
Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)
Egr1
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301116)
endogenous retrovirus
Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)
enhancer
Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)
enzyme activity
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
extended
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
feline aminopeptidase N
Dye, Charlotte, Temperton, Nigel and Siddell, Stuart G. (2007) Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. Journal of General Virology, 88 (6). pp. 1753-1760. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.82666-0)
fusion proteins
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
ganciclovir
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
GCV
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
GDEPT
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)
gene expression
Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)
gene therapy
Greco, O., Marples, B., Wilson, G.D., Joiner, M.C. and Scott, S.D. (2005) Radiation-induced gene therapy. Radiation Research, 163 (6). pp. 707-708. ISSN 0033-7587 (print), 1938-5404 (online) (doi:10.1667/RR3300)
Greco, O., Scott, S.D., Marples, B. and Dachs, D.U. (2002) Cancer gene therapy: 'delivery, delivery, delivery'. Frontiers in Bioscience, 7. d1516-d1524. ISSN 1093-9946 (print), 1093-4715 (on-line) (doi:10.2741/greco)
Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301116)
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.57)
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
Scott, Simon D. and Marples, Brian (2004) Radiation-activated antitumor vectors. In: Suicide Gene Therapy: methods and reviews. Methods in Molecular Medicine (90). Humana Press Inc., New Jersey, USA, pp. 389-402. ISBN 978-0-89603-971-1 (Print), 978-1-59259-429-0 (Online) ISSN 1543-1894 (doi:10.1385/1-59259-429-8:389)
gene vector
Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)
gene-to-vaccine
Loureiro, Silvia, Ren, Junyuan, Phapugrangkul, Pongsathon, Colaco, Camilo A., Bailey, Christopher R., Shelton, Holly, Molesti, Eleonora, Temperton, Nigel J., Barclay, Wendy S. and Jones, Ian M. (2011) Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. Journal of Virology, 85 (6). pp. 3010-3014. ISSN 0022-538X (Print), 1098-5514 (Online) (doi:10.1128/JVI.01241-10)
genetic radiotherapy
Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)
GFP
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
Greco, Olga, Powell, Tanya M., Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2005) Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12 (7). pp. 655-662. ISSN 0929-1903 (print), 1476-5500 (on-line) (doi:10.1038/sj.cgt.7700834)
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301116)
Ghana
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
glioma
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
group 1
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
group 2
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
H1N1 infection
Mahallawi, Waleed H., Kasbekar, Anand V., McCormick, Maxwell S., Hoschler, Katja, Temperton, Nigel, Leong, Samuel C., Beer, Helen, Ferrara, Francesca, McNamara, Paul S. and Zhang, Qibo (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. ISSN 0022-538X (Print), 1098-5514 (Online) (In Press) (doi:10.1128/JVI.03547-12)
H3N8
Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862
H5N1
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
Ibanez, Lorena Itati, De Filette, Marina, Hultberg, Anna, Verrips, Theo, Temperton, Nigel, Weiss, Robin A., Vandevelde, Wesley, Schepens, Bert, Vanlandschoot, Peter and Saelens, Xavier (2011) Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. The Journal of Infectious Diseases, 203 (8). pp. 1063-1072. ISSN 0022-1899 (print), 1537-6613 (on-line) (doi:10.1093/infdis/jiq168)
Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)
H5N1 Influenza
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
H5N1 virus
Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)
H7 lentiviral pseudotype
Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862
Haemagglutinin
Ferrara, Francesca, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Corti, Davide, Scott, Simon D. and Temperton, Nigel J. (2013) The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7. pp. 309-314. ISSN 1747-0862
hemagglutinin
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)
hemagglutinins
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
HERV
Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)
HIF
Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
HPAI
Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862
HRE
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
HRP/IAA
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)
HSVtk
Greco, O., Joiner, M.C., Doleh , A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302482)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
HSVtk/GCV
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302640)
Greco, Olga, Powell, Tanya M., Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2005) Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12 (7). pp. 655-662. ISSN 0929-1903 (print), 1476-5500 (on-line) (doi:10.1038/sj.cgt.7700834)
human
Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)
human influenza virus
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
human prostate tumors
Muthana, Munitta, Giannoudis, Athina, Scott, Simon D., Fang, Hsin-Yu, Coffelt, Seth B., Morrow, Fiona J., Murdoch, Craig, Burton, Julian, Cross, Neil, Burke, Bernard, Mistry, Roshna, Hamdy, Freddie, Brown, Nicola J., Georgopoulos, Lindsay, Hoskin, Peter, Essand, Magnus, Lewis, Claire E. and Maitland, Norman J. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71 (5). pp. 1805-1815. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-10-2349)
hypoxia
Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)
Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
hypoxia responsive element
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
ICS
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
immunity
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)
immunization
Corti, Davide, Suguitan Jr., Amorsolo L., Pinna, Debora, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Vanzetta, Fabrizia, Santos, Celia, Luke, Catherine J., Torres-Velez, Fernando J., Temperton, Nigel J., Weiss, Robin A., Sallusto, Federica, Subbarao, Kanta and Lanzavecchia, Antonio (2010) Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. The Journal of Clinical Investigation, 120 (5). pp. 1663-1673. ISSN 0021-9738 (print), 1558-8238 (on-line) (doi:10.1172/JCI41902)
immunological memory
Mahallawi, Waleed H., Kasbekar, Anand V., McCormick, Maxwell S., Hoschler, Katja, Temperton, Nigel, Leong, Samuel C., Beer, Helen, Ferrara, Francesca, McNamara, Paul S. and Zhang, Qibo (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. ISSN 0022-538X (Print), 1098-5514 (Online) (In Press) (doi:10.1128/JVI.03547-12)
immunoprophylaxis
Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)
inducible nitric oxide synthase
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3302552)
infection
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
influenza
Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)
Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)
influenza A virus
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
influenza vaccination
Loureiro, Silvia, Ren, Junyuan, Phapugrangkul, Pongsathon, Colaco, Camilo A., Bailey, Christopher R., Shelton, Holly, Molesti, Eleonora, Temperton, Nigel J., Barclay, Wendy S. and Jones, Ian M. (2011) Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. Journal of Virology, 85 (6). pp. 3010-3014. ISSN 0022-538X (Print), 1098-5514 (Online) (doi:10.1128/JVI.01241-10)
influenza vaccine
Corti, Davide, Suguitan Jr., Amorsolo L., Pinna, Debora, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Vanzetta, Fabrizia, Santos, Celia, Luke, Catherine J., Torres-Velez, Fernando J., Temperton, Nigel J., Weiss, Robin A., Sallusto, Federica, Subbarao, Kanta and Lanzavecchia, Antonio (2010) Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. The Journal of Clinical Investigation, 120 (5). pp. 1663-1673. ISSN 0021-9738 (print), 1558-8238 (on-line) (doi:10.1172/JCI41902)
influenza virus
Ibanez, Lorena Itati, De Filette, Marina, Hultberg, Anna, Verrips, Theo, Temperton, Nigel, Weiss, Robin A., Vandevelde, Wesley, Schepens, Bert, Vanlandschoot, Peter and Saelens, Xavier (2011) Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. The Journal of Infectious Diseases, 203 (8). pp. 1063-1072. ISSN 0022-1899 (print), 1537-6613 (on-line) (doi:10.1093/infdis/jiq168)
intracellular cytokine staining
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
iron superoxide dismutase
Temperton, Nigel J., Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)
lagos bat virus
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
live SARS virus
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
Llama
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
LPAI
Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862
lyssavirus
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
lyssaviruses
Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)
macrophages
Muthana, Munitta, Giannoudis, Athina, Scott, Simon D., Fang, Hsin-Yu, Coffelt, Seth B., Morrow, Fiona J., Murdoch, Craig, Burton, Julian, Cross, Neil, Burke, Bernard, Mistry, Roshna, Hamdy, Freddie, Brown, Nicola J., Georgopoulos, Lindsay, Hoskin, Peter, Essand, Magnus, Lewis, Claire E. and Maitland, Norman J. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71 (5). pp. 1805-1815. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-10-2349)
magnetic
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.57)
MAP kinase
Hingorani, Mohan, White, Christine L., Merron, Andrew, Peerlinck, Inge, Gore, Martin E., Slade, Andrew, Scott, Simon D., Nutting, Christopher M., Pandha, Hardev S., Melcher, Alan A., Vile, Richard G., Vassaux, Georges and Harrington, Kevin J. (2008) Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors. Cancer Research, 68. pp. 9771-9778. ISSN 0008-5472 (print), 1538-7445 (online) (doi:10.1158/0008-5472.CAN-08-1911)
micro-neutralization
Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862
microassay
Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)
mitochondrial peroxiredoxin
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
molecular switch
Scott, S.D. and Marples, B (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301305)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
mouse model
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
multiple sclerosis
Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)
mutation
Cattoli, Giovanni, Milani, Adelaide, Temperton, Nigel, Zecchin, Bianca, Buratin, Alessandra, Molesti, Eleonora, Meherez Aly, Mona, Arafa, Abdel and Capua, Ilaria (2011) Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus. Journal of Virology, 85 (17). pp. 8718-8724. ISSN 0022-538X (print), 1098-5514 (online) (doi:10.1128/JVI.02403-10)
mutations
Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)
Nab
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
nanobodies
Ibanez, Lorena Itati, De Filette, Marina, Hultberg, Anna, Verrips, Theo, Temperton, Nigel, Weiss, Robin A., Vandevelde, Wesley, Schepens, Bert, Vanlandschoot, Peter and Saelens, Xavier (2011) Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. The Journal of Infectious Diseases, 203 (8). pp. 1063-1072. ISSN 0022-1899 (print), 1537-6613 (on-line) (doi:10.1093/infdis/jiq168)
neuraminidase inhibitor
Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)
neutralisation
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
neutralizing Ab
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
neutralizing antibody
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862
neutralizing mAbs
Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)
neutralizing titers
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
oncology
Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)
ordered
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
overexpression
Temperton, Nigel J., Wilkinson, Shane R., Meyer, David J. and Kelly, John M. (1998) Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Molecular and Biochemical Parasitology, 96 (1-2). pp. 167-176. ISSN 0166-6851 (doi:10.1016/S0166-6851(98)00127-3)
oxidative stress
Temperton, Nigel J., Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)
pandemic potential
Molesti, Eleonora, Cattoli, Giovanni, Ferrara, Francesca, Böttcher-Frieberthäuser, Eva, Terregino , Calogero and Temperton, Nigel (2013) The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7. pp. 315-320. ISSN 1747-0862
pandemic vaccine
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
PBMC
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
pE9/iNOS gene therapy
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.7)
peptidomimetics
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
peripheral blood mononuclear cell
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
peroxide-mediated damage
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
pH stability
Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)
plasma cells
Corti, Davide, Voss, Jarrod, Gamblin, Steven J., Codoni, Giosiana, Macagno, Annalisa, Jarrossay, David, Vachieri, Sebastien G., Pinna, Debora, Minola, Andrea, Vanzetta, Fabrizia, Silacci, Chiara, Fernandez-Rodriguez, Blanca M., Agatic, Gloria, Bianchi, Siro, Giacchetto-Sasselli, Isabella, Calder, Lesley, Sallusto, Federica, Collins, Patrick, Haire, Lesley F., Temperton, Nigel, Langedijk, Johannes P.M., Skehel, John J. and Lanzavecchia, Antonio (2011) A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science, 333 (6044). pp. 850-856. ISSN 0036-8075 (print), 1095-9203 (online) (doi:10.1126/science.1205669)
Portugal in September
Oha, Sawyin, Selleck, Paul, Temperton, Nigel J., Chan, Paul K.S., Capecchi, Barbara, Manavis, Jim, Higgins, Geoff, Burrell, Christopher J. and Kok, Tuckweng (2009) Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses. Journal of Virological Methods, 57 (2). pp. 161-167. ISSN 0166-0934 (doi:10.1016/j.jviromet.2008.12.016)
PR8 influenza virus
Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)
prevention & control
Temperton, N. (2009) BirdFlu2009: Avian Influenza and Human Health. 9-10 September 2009, Oxford, UK. Idrugs: The Investigational Drugs Journal, 12 (11). pp. 686-688. ISSN 1369-7056 (print), 2040-3410 (on-line)
promoter conversion
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
promoters
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
prostate
Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)
protease cleavage
Ferrara, Francesca, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Corti, Davide, Scott, Simon D. and Temperton, Nigel J. (2013) The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7. pp. 309-314. ISSN 1747-0862
protection
Temperton, Nigel J. (2001) DNA vaccines against cytomegalovirus: current progress. International Journal of Antimicrobial Agents, 19 (3). pp. 169-172. ISSN 0924-8579 (doi:10.1016/S0924-8579(01)00492-7)
proteins
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
pseudoparticle neutralization assay
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
pseudotype
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
pseudotype assay
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
pseudotype serology
Ferrara, Francesca, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Corti, Davide, Scott, Simon D. and Temperton, Nigel J. (2013) The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7. pp. 309-314. ISSN 1747-0862
pseudotype virus
Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862
Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)
pseudotypes
Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)
rabies
Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)
rabies vaccines
Wright, Edward, Temperton, Nigel J., Marston, Denise A., McElhinney, Lorraine M., Fooks, Anthiny R. and Weiss, Robin A. (2008) Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology, 89 (9). pp. 2204-2213. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.2008/000349-0)
rabies virus
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
RAD51
Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)
radiation
Chadderton, Naomi, Cowen, Rachel L., Sheppard, Freda C.D, Robinson, Suzanne, Greco, Olga, Scott, Simon D., Stratford, Ian J., Patterson, Adam V. and Williams, Kaye J. (2005) Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumour cells. International Journal of Radiation Oncology*Biology*Physics, 62 (1). pp. 213-222. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2005.01.031)
Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/gt.2008.7)
Greco, O., Marples, B., Wilson, G.D., Joiner, M.C. and Scott, S.D. (2005) Radiation-induced gene therapy. Radiation Research, 163 (6). pp. 707-708. ISSN 0033-7587 (print), 1938-5404 (online) (doi:10.1667/RR3300)
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
Greco, Olga, Powell, Tanya M., Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2005) Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12 (7). pp. 655-662. ISSN 0929-1903 (print), 1476-5500 (on-line) (doi:10.1038/sj.cgt.7700834)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2002) Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38 (2). pp. 231-239. ISSN 0959-8049 (doi:10.1016/S0959-8049(01)00367-7)
Marples, B., Greco, O., Joiner, M.C. and Scott, S.D. (2003) Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9 (26). pp. 2105-2112. ISSN 1381-6128 (print), 1873-4286 (on-line) (doi:10.2174/1381612033454090)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
radiation-responsive elements
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
radiotherapy
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301823)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:10.1038/sj.gt.3301223)
Scott, Simon D. and Marples, Brian (2004) Radiation-activated antitumor vectors. In: Suicide Gene Therapy: methods and reviews. Methods in Molecular Medicine (90). Humana Press Inc., New Jersey, USA, pp. 389-402. ISBN 978-0-89603-971-1 (Print), 978-1-59259-429-0 (Online) ISSN 1543-1894 (doi:10.1385/1-59259-429-8:389)
receptor binding
Shelton, Holly, Roberts, Kim L., Molesti, Eleonora, Temperton, Nigel and Barclay, Wendy S. (2013) Mutations in hemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. Journal of General Virology. ISSN 0022-1317 (Print), 1465-2099 (Online) (In Press) (doi:10.1099/vir.0.050526-0)
respiratory syncytial virus
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
retroviral pseudotypes
Dye, Charlotte, Temperton, Nigel and Siddell, Stuart G. (2007) Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. Journal of General Virology, 88 (6). pp. 1753-1760. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.82666-0)
retroviral vector
Lipnik, Karoline, Greco, Olga, Scott, Simon, Knapp, Elzbieta, Mayrhofer, Elisabeth, Rosenfellner, Doris, Günzburg, Walter H., Salmons, Brian and Hohenadl, Christine (2006) Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology, 349 (1). pp. 121-133. ISSN 0042-6822 (doi:10.1016/j.virol.2005.12.038)
SARS
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
scFv
Ascione, Alessandro, Capecchi, Barbara, Campitelli, Laura, Imperiale, Valentina, Flegoa, Michela, Zamboni, Silvia, Gellini, Mara, Alberini, Isabella, Pittiglio, Eliana, Donatelli, Isabella, Temperton, Nigel J. and Cianfriglia, Maurizio (2009) Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1. Antiviral Research, 83 (3). pp. 238-244. ISSN 0166-3542 (doi:10.1016/j.antiviral.2009.05.005)
serological methods
Alberini, Isabella, Del Tordello, Elena, Fasolo, Alba, Temperton, Nigel J., Galli, Grazia, Gentile, Chiara, Montomoli, Emanuele, Hilbert, Anne K., Banzhoff, Angelika, Del Giudice, Giuseppe, Donnelly, John J., Rappuoli, Rino and Capecchi, Barbara (2009) Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine, 27 (43). pp. 5998-6003. ISSN 0264-410X (doi:10.1016/j.vaccine.2009.07.079)
serology
Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)
Wright, Edward, Hayman, David T.S., Vaughan, Aisling, Temperton, Nigel J., Wood, James L.N., Cunningham, Andrew A., Suu-Ire, Richard, Weiss, Robin A. and Fooks, Anthony R. (2010) Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology, 408 (2). pp. 183-189. ISSN 0042-6822 (doi:10.1016/j.virol.2010.09.014)
severe acute respiratory syndrome
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
SFC
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
Sjogren’s syndrome
Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)
spot forming cell
Li, Chris Ka-fai, Wu, Hao, Yan, Huiping, Ma, Shiwu, Wang, Lili, Zhang, Mingxia, Tang, Xiaoping, Temperton, Nigel J., Weiss, Robin A., Brenchley, Jason M., Douek, Daniel C., Mongkolsapaya, Juthathip, Tran, Bac-Hai, Lin, Chen-lung Steve, Screaton, Gavin R., Hou, Jin-lin, McMichael, Andrew J. and Xu, Xiao-Ning (2008) T Cell responses to whole SARS Coronavirus in humans. The Journal of Immunology, 181 (8). pp. 5490-5500. ISSN 0022-1767 (print), 1550-6606 (on-line)
SRF
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (print), 1476-5462 (electronic) (doi:10.1038/sj.gt.3301822)
SRH
Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862
sugar amino acids
Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)
suicide gene
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
suicide gene therapy
Greco, Olga and Scott, Simon (2007) Tumor hypoxia and targeted gene therapy. International Review of Cytology, 257. pp. 181-212. ISSN 0074-7696 (doi:10.1016/S0074-7696(07)57005-1)
superoxide dismutase
Temperton, Nigel J., Wilkinson, Shane R., Meyer, David J. and Kelly, John M. (1998) Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Molecular and Biochemical Parasitology, 96 (1-2). pp. 167-176. ISSN 0166-6851 (doi:10.1016/S0166-6851(98)00127-3)
T. cruzi
Wilkinson, Shane R., Temperton, Nigel J., Mondragon, Angeles and Kelly, John M. (2000) Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. The Journal of Biological Chemistry, 275 (11). pp. 8220-8225. ISSN 0021-9258 (print), 1083-351X (on-line) (doi:10.1074/jbc.275.11.8220)
targeting
Scott, Simon D. and Greco, Olga (2004) Radiation and hypoxia inducible gene therapy systems. Cancer and Metastasis Reviews, 23 (3-4). pp. 269-276. ISSN 0167-7659 (print), 1573-7233 (online) (doi:10.1023/B:CANC.0000031766.58614.f1)
TMPRSS2
Scott, Simon, Molesti, Eleonora, Temperton, Nigel, Ferrara, Francesca, Böttcher-Friebertshäuser, Eva and Daly, Janet (2012) The use of equine influenza pseudotypes for serological screening. Journal of Molecular and Genetic Medicine, 6. pp. 304-308. ISSN 1747-0862
transfection
Temperton, Nigel J., Wilkinson, Shane R., Meyer, David J. and Kelly, John M. (1998) Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Molecular and Biochemical Parasitology, 96 (1-2). pp. 167-176. ISSN 0166-6851 (doi:10.1016/S0166-6851(98)00127-3)
Trypanosoma cruzi
Temperton, Nigel J., Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)
Temperton, Nigel J., Wilkinson, Shane R., Meyer, David J. and Kelly, John M. (1998) Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Molecular and Biochemical Parasitology, 96 (1-2). pp. 167-176. ISSN 0166-6851 (doi:10.1016/S0166-6851(98)00127-3)
tumor
Greco, Olga, Marples, Brian, Joiner, Michael C. and Scott, Simon D. (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197 (3). pp. 312-325. ISSN 0021-9541 (print), 1097-4652 (on-line) (doi:10.1002/jcp.10374)
Scott, Simon D. and Marples, Brian (2004) Radiation-activated antitumor vectors. In: Suicide Gene Therapy: methods and reviews. Methods in Molecular Medicine (90). Humana Press Inc., New Jersey, USA, pp. 389-402. ISBN 978-0-89603-971-1 (Print), 978-1-59259-429-0 (Online) ISSN 1543-1894 (doi:10.1385/1-59259-429-8:389)
tumour
Collis, S.J., Tighe, A., Scott, S.D., Roberts, S.A., Hendry, J.H. and Margison, G.P. (2001) Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells. Nucleic Acids Research, 29 (7). pp. 1534-1538. ISSN 0305-1048 (print), 1362-4962 (on-line) (doi:10.1093/nar/29.7.1534)
type I feline coronaviruses
Dye, Charlotte, Temperton, Nigel and Siddell, Stuart G. (2007) Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. Journal of General Virology, 88 (6). pp. 1753-1760. ISSN 0022-1317 (print), 1465-2099 (on-line) (doi:10.1099/vir.0.82666-0)
vaccines
Temperton, Nigel J., Chan, Paul K., Simmons, Graham, Zambon, Maria C., Tedder, Richard S., Takeuchi, Yasuhiro and Weiss, Robin A. (2005) Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerging Infectious Diseases, 11 (3). pp. 411-416. ISSN 1080-6059 (doi:10.3201/eid1103.040906)
Vilamoura
Oha, Sawyin, Selleck, Paul, Temperton, Nigel J., Chan, Paul K.S., Capecchi, Barbara, Manavis, Jim, Higgins, Geoff, Burrell, Christopher J. and Kok, Tuckweng (2009) Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses. Journal of Virological Methods, 57 (2). pp. 161-167. ISSN 0166-0934 (doi:10.1016/j.jviromet.2008.12.016)
viral epitope
Hultberg, Anna, Temperton, Nigel J., Rosseels, Valerie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibanez, Lorena Itatı, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A., Saelens, Xavier, Melero, Jose A., Verrips, C. Theo, Van Gucht, Steven and de Haard, Hans J. (2011) Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS ONE, 6 (4). pp. 1-12. ISSN 1932-6203 (on-line) (doi:10.1371/journal.pone.0017665)
viral neutralization
Temperton, Nigel J., Hoschler, Katja, Major, Diane, Nicolson, Carolyn, Manvell, Ruth, Hien, Vo Minh, Ha, Do Quang, de Jong, Menno, Zambon, Maria, Takeuchi, Yasuhiro and Weiss, Robin A. (2007) A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies. Influenza and other respiratory viruses, 1 (3). pp. 105-112. ISSN 1750-2659 (online) (doi:10.1111/j.1750-2659.2007.00016.x)
viral release assay
Su, Ching-Yao, Wang, Shi-Yun, Shie, Jiun-Jie, Jeng, King-Song, Temperton, Nigel J., Fang, Jim-Min, Wong, Chi-Huey and Cheng, Yih-Shyun E. (2008) In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Research, 79 (3). pp. 199-205. ISSN 0166-3542 (doi:10.1016/j.antiviral.2008.03.002)
virus infection
Loureiro, Silvia, Ren, Junyuan, Phapugrangkul, Pongsathon, Colaco, Camilo A., Bailey, Christopher R., Shelton, Holly, Molesti, Eleonora, Temperton, Nigel J., Barclay, Wendy S. and Jones, Ian M. (2011) Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. Journal of Virology, 85 (6). pp. 3010-3014. ISSN 0022-538X (Print), 1098-5514 (Online) (doi:10.1128/JVI.01241-10)