Ghanizadeh Tabriz, Atabak, Gonot-Munck, Quentin, Baudoux, Arnaud, Garg, Vivek ORCID: 0000-0002-8515-4759, Farnish, Richard, L.Katsamenis, Orestis, Hui, Ho-Wah, Boersen, Nathan, Roberts, Sandra, Jones, John and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2023) 3D printing of personalised Carvedilol tablets using selective laser sintering. Pharmaceutics, 15 (9):2230. pp. 1-19. ISSN 1999-4923 (Online) (doi:https://doi.org/10.3390/pharmaceutics15092230)

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Abstract

Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.

Item Type:	Article
Additional Information:	This article belongs to the Special Issue Recent Non-oral Dosage Form Development: Focus on 3D-Printed Formulations.
Uncontrolled Keywords:	3D printing; selective laser sintering; personalised medicines; oral; carvedilol
Subjects:	R Medicine > RS Pharmacy and materia medica T Technology > T Technology (General) T Technology > TP Chemical technology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Medway School of Pharmacy Faculty of Engineering & Science > School of Engineering (ENG) Faculty of Engineering & Science > School of Science (SCI) Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Last Modified:	30 Aug 2023 11:25
URI:	http://gala.gre.ac.uk/id/eprint/43822

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