Khizer, Zara, Akram, Muhammad R., Sarfraz, Rai M., Nirwan, Jorabar Singh, Farhaj, Samia, Yousaf, Maria, Hussain, Tariq, Lou, Shan ORCID: 0000-0002-8426-5596 , Timmins, Peter ORCID: 0000-0002-5840-0678 , Conway, Barbara R. ORCID: 0000-0001-5570-3318 and Ghori, Muhammad Usman (2019) Plasticiser-free 3D printed hydrophilic matrices: Quantitative 3D surface texture, mechanical, swelling, erosion, drug release and pharmacokinetic studies. Polymers, 11 (7):1095. ISSN 2073-4360 (Online) (doi:https://doi.org/10.3390/polym11071095)

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Abstract

Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices.

Item Type:	Article
Additional Information:	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords:	3D printing; hot melt extrusion; hydroxypropyl methyl cellulose (HPMC); swelling; erosion; drug release; pharmacokinetics; Young’s modulus; 3D surface texture
Subjects:	T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Last Modified:	02 Jul 2019 16:38
URI:	http://gala.gre.ac.uk/id/eprint/24722

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