Article

Coakley-Youngs, Emma, Ranatunga, Medhavi, Richardson, Simon ORCID: 0000-0002-7927-0649 , Getti, Giulia ORCID: 0000-0003-1402-8496 , Shorter, Susan and Fivaz, Marc ORCID: 0000-0003-1003-7934 (2022) Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle. Biology Open, 11 (9):bio058941. pp. 1-11. ISSN 2046-6390 (Online) (doi:https://doi.org/10.1242/bio.058941)

Feron, Benedita and Richardson, Simon ORCID: 0000-0002-7927-0649 (2022) Engineering protein toxins to modulate the intracellular trafficking of biologics into exosomes for third order drug targeting. European Journal of Extracellular Vesicles, 2. pp. 1-14. ISSN 2001-3078

Ranatunga, Medhavi, Rai, Rajeev, Richardson, Simon C. W. ORCID: 0000-0002-7927-0649 , Dyer, Paul, Harbige, Laurence, Deacon, Andrew ORCID: 0000-0001-7630-4973 , Pecorino, Lauren and Getti, Giulia T. M. ORCID: 0000-0003-1402-8496 (2019) Leishmania aethiopica cell-to-cell spreading involves caspase-3, AkT and NF-jB but not PKC-d activation and involves uptake of LAMP-1 positive bodies containing parasites. The FEBS Journal (Federation of European Biochemical Societies), 287 (9). pp. 1777-1797. ISSN 1742-464X (Print), 1742-4658 (Online) (doi:https://doi.org/10.1111/febs.15166)

Feron, Benedita Kaç Labbé and Richardson, Simon Clifford Wainwright ORCID: 0000-0002-7927-0649 (2018) The delivery of personalised, precision medicines via synthetic proteins. Drug Delivery Letters, 9 (1). pp. 79-88. ISSN 2210-3031 (Print), 2210-304X (Online) (doi:https://doi.org/10.2174/2210303109666181224115722)

Satchi-Fainaro, Ronit, Vicent, Maria and Richardson, Simon ORCID: 0000-0002-7927-0649 (2017) Professor Ruth Duncan: a pioneer in the field of polymer therapeutics. Journal of Drug Targeting, 25 (9-10). pp. 757-758. ISSN 1061-186X (Print), 1029-2330 (Online) (doi:https://doi.org/10.1080/1061186X.2017.1371722)

Ghosh, Saptarshi, Bouvaine, Sophie ORCID: 0000-0002-0788-3243 , Richardson, Simon C. W. ORCID: 0000-0002-7927-0649 , Ghanim, Murad and Maruthi, M.N. ORCID: 0000-0002-8060-866X (2017) Fitness costs associated with infections of secondary endosymbionts in the cassava whitefly species Bemisia tabaci. Journal of Pest Science, 91. pp. 17-28. ISSN 1612-4758 (Print), 1612-4766 (Online) (doi:https://doi.org/10.1007/s10340-017-0910-8)

Shorter, Susan, Pettit, Marie W., Dyer, Paul D.R., Coakley-Youngs, J. Emma, Gorringe-Pattrick, Monique A. M., El-Daher, Samer and Richardson, Simon ORCID: 0000-0002-7927-0649 (2017) Green Fluorescent Protein (GFP): is seeing believing and is that enough? Journal of Drug Targeting, 25 (9-10). pp. 809-817. ISSN 1061-186X (Print), 1029-2330 (Online) (doi:https://doi.org/10.1080/1061186X.2017.1358725)

Rai, Rajeev, Dyer, Paul, Richardson, Simon ORCID: 0000-0002-7927-0649 , Harbige, Laurence and Getti, Giulia ORCID: 0000-0003-1402-8496 (2017) Apoptotic induction induces Leishmania aethiopica and L. mexicana spreading in terminally differentiated THP-1 cells. Parasitology, 144 (14). pp. 1912-1921. ISSN 0031-1820 (Print), 1469-8161 (Online) (doi:https://doi.org/10.1017/S0031182017001366)

Shorter, Susan, Gollings, Alexander, Gorringe-Pattrick, Monique, Coakley, Emma, Dyer, Paul D.R. and Richardson, Simon ORCID: 0000-0002-7927-0649 (2016) The potential of toxin-based drug delivery systems for enhanced nucleic acid therapeutic delivery. Expert Opinion on Drug Delivery, 14 (5). pp. 685-696. ISSN 1742-5247 (Print), 1744-7593 (Online) (doi:https://doi.org/10.1080/17425247.2016.1227781)

Mohsen, R., Alexander, B. D., Richardson, S. C. W. ORCID: 0000-0002-7927-0649 , Mitchell, J. C. ORCID: 0000-0003-2945-3292 , Diab, A. A. and Snowden, M. J. ORCID: 0000-0002-1087-2692 (2016) Design, synthesis, characterization and toxicity studies of Poly (N-Iso-Propylacrylamide-co-Lucifer Yellow) particles for drug delivery applications. Journal of Nanomedicine and Nanotechnology, 7 (2):1000363. pp. 363-372. ISSN 2157-7439 (doi:https://doi.org/10.4172/2157-7439.1000363)

Dyer, Paul D. R., Kotha, Arun K., Gollings, Alex S., Shorter, Susan A., Shepherd, Thomas R., Pettit, Marie W., Alexander, Bruce D., Getti, Giulia T. M. ORCID: 0000-0003-1402-8496 , El-Daher, Samer, Baillie, Les and Richardson, Simon C. W. ORCID: 0000-0002-7927-0649 (2016) An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin toxin. Biochimica et Biophysica Acta (BBA) - General Subjects, 1860 (7). pp. 1541-1550. ISSN 0304-4165 (doi:https://doi.org/10.1016/j.bbagen.2016.03.024)

Dyer, Paul D.R., Shepherd, Thomas R., Gollings, Alexander S., Shorter, Susan A., Gorringe-Pattrick, Monique A. M., Tang, Chun-Kit, Cattoz, Beatrice N., Baillie, Les, Griffiths, Peter C. ORCID: 0000-0002-6686-1271 and Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2015) Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Journal of Controlled Release, 220 (A). pp. 316-328. ISSN 0168-3659 (doi:https://doi.org/10.1016/j.jconrel.2015.10.054)

Boateng, Joshua ORCID: 0000-0002-6310-729X , Momoh, Frederick, Richardson, Simon ORCID: 0000-0002-7927-0649 , Chowdhry, Babur and Mitchell, John ORCID: 0000-0003-2945-3292 (2015) Development functional characterization of alginate dressing as potential protein delivery system for wound healing. International Journal of Biological Macromolecules, 81. pp. 137-150. ISSN 0141-8130 (Print), 1879-0003 (Online) (doi:https://doi.org/10.1016/j.ijbiomac.2015.07.037)

Pettit, Marie, Dyer, Paul D.R., Mitchell, John C. ORCID: 0000-0003-2945-3292 , Griffiths, Peter C. ORCID: 0000-0002-6686-1271 , Alexander, Bruce, Cattoz, Beatrice, Heenan, Richard K., King, Stephen M., Schweins, Ralf, Pullen, Frank, Wicks, Stephen R. and Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2014) Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). International Journal of Pharmaceutics, 468 (1-2). pp. 264-271. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2014.03.046)

Griffiths, Peter C. ORCID: 0000-0002-6686-1271 , Mauro, Nicolo, Murphy, Damien M., Carter, Emma, Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Dyer, Paul and Ferruti, Paolo (2013) Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromolecular Bioscience, 13 (5). pp. 641-649. ISSN 1616-5187 (Print), 1616-5195 (Online) (doi:https://doi.org/10.1002/mabi.201200462)

Duncan, Ruth and Richardson, Simon ORCID: 0000-0002-7927-0649 (2012) Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges. Molecular Pharmaceutics, 9 (9). pp. 2380-2402. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/mp300293n)

Pettit, Marie W., Griffiths, Peter ORCID: 0000-0002-6686-1271 , Ferruti, Paolo and Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2011) Poly(amidoamine) polymers: soluble linear amphiphilic drug-delivery systems for genes, proteins and oligonucleotides. Therapeutic Delivery, 2 (7). pp. 907-917. ISSN 2041-5990 (doi:https://doi.org/10.4155/tde.11.55)

Dyer, Paul D.R. and Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2011) Delivery of biologics to select organelles – the role of biologically active polymers. Expert Opinion on Drug Delivery, 8 (4). pp. 403-407. ISSN 1742-5247 (doi:https://doi.org/10.1517/17425247.2011.558080)

Liu, Xi, Hein, Jennifer, Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Basse, Per H., Toptan, Tuna, Moore, Patrick S., Gjoerup, Ole V. and Chang, Yuan (2011) Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. The Journal of Biological Chemistry, 286 (19). pp. 17079-17090. ISSN 0021-9258 (Print), 1083-351X (Online) (doi:https://doi.org/10.1074/jbc.M110.192856)

Ferguson, Elaine L., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 and Duncan, Ruth (2010) Studies on the mechanism of action of dextrin−phospholipase A₂and its suitability for use in combination therapy. Molecular Pharmaceutics, 7 (2). pp. 510-521. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/mp900232a)

Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Pattrick, Nicola G., Lavignac, Nathalie, Ferruti, Paolo and Duncan, Ruth (2009) Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo. Journal of Controlled Release, 142 (1). pp. 78-88. ISSN 0168-3659 (doi:https://doi.org/10.1016/j.jconrel.2009.09.025)

Spencer, John, Rathnam, Rajendra P., Montukuri, Mahesh, Kotha, Arun K., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Hazrati, Ali, Hartley, John A., Male, Louise and Hursthouse, Michael B. (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions (22). pp. 4299-4303. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/b819061e)

Spencer, John, Mendham, Andrew P., Kotha, Arun K., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Hillard, Elizabeth A., Jaouen, Gérard, Male, Louise and Hursthouse, Michael B. (2008) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 2009 (6). pp. 918-921. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/B816249B)

Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Wallom, Kerri-Lee, Ferguson, Elaine L., Deacon, Samuel P.E., Davies, Matthew W., Powell, Alison J., Piper, Robert C. and Duncan, Ruth (2008) The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery. Journal of Controlled Release, 127 (1). pp. 1-11. ISSN 0168-3659 (doi:https://doi.org/10.1016/j.jconrel.2007.12.015)

Zhang, Yanling, Zolov, Sergey N., Chow, Clement Y., Slutsky, Shalom G., Richardson, Simon C. ORCID: 0000-0002-7927-0649 , Piper, Robert C., Yang, Baoli, Nau, Johnathan J., Westrick, Randal J., Morrison, Sean J., Meisler, Miriam H. and Weisman, Lois S. (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. PNAS, 104 (44). pp. 17518-17523. ISSN 1091-6490 (doi:https://doi.org/10.1073/pnas.0702275104)

Book Section

Dyer, Paul D.R., Kotha, Arun K., Pettit, Marie W. and Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2013) Imaging select mammalian organelles using fluorescent microscopy: application to drug delivery. In: Weissig, Volkmar, Elbayoumi, Tamer and Olsen, Mark, (eds.) Methods in Molecular Biology: Cellular and subcellular nanotechnology. Methods in Molecular Biology, 991 . Humana Press, New York, USA, pp. 195-210. ISBN 9781627033350 (doi:https://doi.org/10.1007/978-1-62703-336-7)

Fenili, Fabio, Ferrari, Elena, Manfredi, Amedea, Cavalli, Roberta, Richardson, Simon ORCID: 0000-0002-7927-0649 , Ranucci, Elisabetta and Ferruti, Paolo (2012) Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins. In: Sebastian, Mathew, Ninan, Neetha and Haghi, A.K., (eds.) Nanomedicine and Drug Delivery. Advances in Nanoscience and Nanotechnology (v.1). Apple Academic Press Inc., Toronto, Canada & New Jersey, USA., pp. 51-64. ISBN 978-1-926895-17-8 (hardback), 978-1-46-656007-9 (e-book)

Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 (2010) Tracking intracellular polymer localization via fluorescence microscopy. In: Weissig, Volkmar and D'Souza, Gerard G.M., (eds.) Organelle-Specific Pharmaceutical Nanotechnology. John Wiley & Sons, Inc., pp. 177-192. ISBN 9780470631652

Patent

Richardson, Dyer, Mitchell (2014) WO 2014203008 A1 Antisense oligonucleotide compositions. WO2014203008 A1.