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The delivery of personalised, precision medicines via synthetic proteins

The delivery of personalised, precision medicines via synthetic proteins

Feron, Benedita Kaç Labbé and Richardson, Simon Clifford Wainwright (2018) The delivery of personalised, precision medicines via synthetic proteins. Drug Delivery Letters, 9 (1). pp. 79-88. ISSN 2210-3031 (Print), 2210-304X (Online) (doi:https://doi.org/10.2174/2210303109666181224115722)

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Abstract

Introduction:
The design of advanced drug delivery systems based on synthetic and su-pramolecular chemistry has been very successful. Liposomal doxorubicin (Caelyx®), and liposomal daunorubicin (DaunoXome®), estradiol topical emulsion (EstrasorbTM) as well as soluble or erodible polymer systems such as pegaspargase (Oncaspar®) or goserelin acetate (Zoladex®) represent considerable achievements.

The Problem:
As deliverables have evolved from low molecular weight drugs to biologics (currently representing approximately 30% of the market), so too have the demands made of advanced drug delivery technology. In parallel, the field of membrane trafficking (and endocytosis) has also matured. The trafficking of specific receptors i.e. material to be recycled or destroyed, as well as the trafficking of protein toxins has been well characterized. This, in conjunction with an ability to engineer synthetic, recombinant proteins provides several possibilities.

The Solution:
The first is using recombinant proteins as drugs i.e. denileukin diftitox (Ontak®) or agalsidase beta (Fabrazyme®). The second is the opportunity to use protein toxin architecture to reach targets that are not normally accessible. This may be achieved by grafting regulatory domains from multiple species to form synthetic proteins, engineered to do multiple jobs. Examples include access to the nucleocytosolic compartment. Herein the use of synthetic proteins for drug delivery has been reviewed.

Item Type: Article
Uncontrolled Keywords: siRNA, toxins, antisense, endocytosis, membraine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Biomedical Science Research Group
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 29 May 2019 15:26
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/22856

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