Allwood, B. W., Stolbrink, M., Baines, N., Louw, E., Wademan, D. T., Lupton-Smith, A., Nel, S., Maree, D., Mpagama, S., Osman, Muhammad ORCID: https://orcid.org/0000-0003-3818-9729, Marx, F. M., Hoddinott, G., Lesosky, M., Rylance, J. and Mortimer, K. (2021) Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function. The International Journal of Tuberculosis and Lung Disease, 25 (4):9. pp. 262-270. ISSN 1027-3719 (Print), 1815-7920 (Online) (doi:10.5588/ijtld.20.0906)

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Abstract

BACKGROUND: Persistent respiratory symptoms and lung function deficits are common after patients with TB. We aimed to define the burden of post-TB lung disease (PTLD) and assess associations between symptoms and impairment in two high TB incidence communities.
METHODS: This was a cross-sectional survey of adults in Cape Town, South Africa who completed TB treatment 1–5 years previously. Questionnaires, spirometry and 6-minute walking distance (6MWD) were used to assess relationships between outcome measures and associated factors.
RESULTS: Of the 145 participants recruited (mean age: 42 years, range: 18–75; 55 [38%] women), 55 (38%) had airflow obstruction and 84 (58%) had low forced vital capacity (FVC); the mean 6MWD was 463 m (range: 240–723). Respiratory symptoms were common: chronic cough (n = 27, 19%), wheeze (n = 61, 42%) and dyspnoea (modified MRC dyspnoea score 3 or 4: n = 36, 25%). There was poor correlation between FVC or obstruction and 6MWD. Only low body mass index showed consistent association with outcomes on multivariable analyses. Only 19 (13%) participants had a diagnosis of respiratory disease, and 16 (11%) currently received inhalers.
CONCLUSION: There was substantial burden of symptoms and physiological impairment in this “cured” population, but poor correlation between objective outcome measures, highlighting deficits in our understanding of PTLD.

Item Type:	Article
Uncontrolled Keywords:	post-tuberculosis; obstruction; physiology; post-TB; restriction; spirometry
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > RB Pathology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	23 Mar 2022 15:18
URI:	http://gala.gre.ac.uk/id/eprint/35550

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