Temperton, Nigel ORCID: https://orcid.org/0000-0002-7978-3815, Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)

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Abstract

Development of new chemotherapeutic agents against Chagas’ disease is a major WHO objective [I]. Drugs currently in use, such as nifurtimox, often have serious side effects and can fail to eradicate parasitemia [2]. The trypanocidal effects of nifurtimox are thought to be mediated through the generation of nitro-radicals which promote the formation of toxic oxygen metabolites within the parasite [3,4]. Oxidative stress resulting from the generation of the superoxide radical has also been implicated as a mechanism of action of gentian violet, an agent employed to prevent transmission of Chagas’ disease by blood transfusion [5,6]. Thus, identification and functional analysis of Trypanosoma cruzi enzymes involved in antioxidant defence could be of importance in the context of improved chemotherapeutic approaches.

Item Type:	Article
Additional Information:	[1] Nucleotide sequence data reported in this paper are available in the GenBank database with accession number U39401.
Uncontrolled Keywords:	Trypanosoma cruzi; Iron superoxide dismutase; Oxidative stress
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Medway School of Pharmacy
Related URLs:	Publisher Organisation
Last Modified:	03 Jan 2017 14:26
URI:	http://gala.gre.ac.uk/id/eprint/8572

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