Pulikotil, Feba, Saiter, Jeremy, Burnett, John, Goodall, Iain C.A., Claringbold, Bini and Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212 (2024) eFluorination for the rapid synthesis of Carbamoyl fluorides from oxamic acids. Organic Letters. ISSN 1523-7060 (Print), 1523-7052 (Online) (doi:10.1021/acs.orglett.4c01605)

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Abstract

In this letter, we disclose the anodic oxidation of oxamic acids in the presence of Et3N·3HF as a practical, scalable, and robust method to rapidly access carbamoyl fluorides from readily available and stable precursors. The simplicity of this method also led us to develop the first flow electrochemical preparation of carbamoyl fluorides, demonstrating scale-up feasibility as a proof of concept.

Item Type:	Article
Uncontrolled Keywords:	fluorination; carbamoyl fluoride; electrosynthesis; anodic oxidation
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	17 Jul 2024 13:38
URI:	http://gala.gre.ac.uk/id/eprint/47620

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