El-Mahrouky, Yomna ORCID: 0009-0005-2633-6164 (2022) New Nano Selenium model for cancer management. In: 3rd PUA International Conference, 14th May 2022, Alexandria, Egypt. (Unpublished)

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Abstract

This study aims to develop a simple method for synthesis of novel form vitamin c-coated selenium nanoparticles labeled with technetium-99m as a potential protective agent against breast cancer and a radiopharmaceutical for imaging of solid tumors. SeNPs are considered as a novel form of selenium that possesses strong antioxidant properties that increase the bioavailability and effects of selenium in addition to decreasing its toxicity. Also, owing to the Nano-size, SeNPs can cross intracellular and extracellular barriers of cancer tissues, so, increasing their sensitivity and selectivity to the cancer cells avoiding the surrounding healthy tissues. Vitamin C inhibits tumor growth by disrupting Phase G1 in the cell cycle and inducing apoptosis in abnormal cells. Technetium-99m radioactive isotopes emit gamma rays, which are picked up by a gamma camera and used for imaging. [99mTc-Vit-C (SeNPs)] complex is considered as strong antioxidant which makes it an excellent candidate for protection against cancer.

Item Type:	Conference or Conference Paper (Poster)
Uncontrolled Keywords:	nano-medicine; Nano Selenium; antioxidant; anticancer; technetium-99m
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Last Modified:	10 Jul 2023 08:48
URI:	http://gala.gre.ac.uk/id/eprint/42710

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