Bonithon, Roxane ORCID: https://orcid.org/0000-0002-4252-0894, Lupton, Colin ORCID: https://orcid.org/0000-0001-8054-2712, Roldo, Marta ORCID: https://orcid.org/0000-0003-2242-7761, Dunlop, Joseph Nicholas, Blunn, Gordon William, Witte, Frank ORCID: https://orcid.org/0000-0001-9154-6217 and Tozzi, Gianluca (2022) Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading: a mechanistic study. Bioactive Materials, 19. pp. 406-417. ISSN 2452-199X (Online) (doi:10.1016/j.bioactmat.2022.04.012)

Preview

PDF (Publisher VoR) 42583_TOZZI_Open_porous_magnesium_based_scaffolds_withstand_in_vitro_corrosion.pdf - Published Version Available under License Creative Commons Attribution. Download (10MB) | Preview

Abstract

The successful application of magnesium (Mg) alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity. This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks' Balanced Salt Solution (HBSS) with and without in situ cyclic compression (30 N/1 Hz). The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation. Although in situ cyclic compression induced acceleration of the corrosion rate, probably due to local disruption of the coating layer where fatigue microcracks were formed, no critical failures in the overall scaffold were observed, indicating that the mechanical integrity of the Mg scaffolds was preserved. Structural changes, due to the accumulation of corrosion debris between the scaffold fibres, resulted in a significant increase (p < 0.05) in the material volume fraction from 0.52 ± 0.07 to 0.47 ± 0.03 after 14 days of corrosion. However, despite an increase in fibre material loss, the accumulated corrosion products appear to have led to an increase in Young's modulus after 14 days as well as lower third principal strain (εp3) accumulation (−91000 ± 6361 με and −60093 ± 2414 με after 2 and 14 days, respectively). Therefore, this innovative Mg scaffold design and composition provide a bone replacement, capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs.

Item Type:	Article
Uncontrolled Keywords:	magnesium alloys; bone regeneration; in vitro corrosion; X-ray computed tomography (XCT); digital volume correlation (DVC)
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Last Modified:	16 May 2023 09:04
URI:	http://gala.gre.ac.uk/id/eprint/42583

Actions (login required)

View Item

Downloads