Peña Fernández, Marta, Kao, Alexander P., Bonithon, Roxane, Howells, David, Bodey, Andrew J., Wanelik, Kazimir, Witte, Frank, Johnston, Richard, Arora, Hari and Tozzi, Gianluca (2021) Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation. Acta Biomaterialia, 131. pp. 424-439. ISSN 1742-7061 (Print), 1878-7568 (Online) (doi:https://doi.org/10.1016/j.actbio.2021.06.014)

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Abstract

Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions.

Item Type:	Article
Uncontrolled Keywords:	bone; time-resolved SR-microCT; continuous in situ mechanics; digital volume correlation; time-dependent behaviour
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Last Modified:	22 May 2023 10:39
URI:	http://gala.gre.ac.uk/id/eprint/42578

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