Osman, Muhammad ORCID: https://orcid.org/0000-0003-3818-9729, du Preez, Karen, Seddon, James A., Claassens, Mareli M., Dunbar, Rory, Dlamini, Sicelo S., Welte, Alex, Naidoo, Pren and Hesseling, Anneke C. (2021) Mortality in South African children and adolescents routinely treated for tuberculosis. Pediatrics, 147 (4):e2020032490. ISSN 0031-4005 (Print), 1098-4275 (Online) (doi:10.1542/peds.2020-032490)

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Abstract

BACKGROUND: In South Africa, tuberculosis (TB) is a leading cause of death among those abstract, 20 years of age. We describe changes in TB mortality among children and adolescents in South Africa over a 13-year period, identify risk factors for mortality, and estimate excess TBrelated mortality.
METHODS: Retrospective analysis of all patients ,20 years of age routinely recorded in the national electronic drug-susceptible TB treatment register (2004–2016). We developed a multivariable Cox regression model for predictors of mortality and used estimates of mortality among the general population to calculate standardized mortality ratios (SMRs).
RESULTS: Between 2004 and 2016, 729 463 children and adolescents were recorded on TB treatment; 84.0% had treatment outcomes and 2.5% (18 539) died during TB treatment. The case fatality ratio decreased from 3.3% in 2007 to 1.9% in 2016. In the multivariable Cox regression model, ages 0 to 4, 10 to 14, and 15 to 19 years (compared with ages 5 to 9 years) were associated with increased risk of mortality, as was HIV infection, previous TB treatment, and extrapulmonary involvement. The SMR of 15 to 19-year-old female patients was more than double that of male patients the same age (55.3 vs 26.2). Among 10 to 14-year-olds and those who were HIV-positive,

Item Type:	Article
Uncontrolled Keywords:	paediatric tuberculosis; tuberculosis outcomes; mortality
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > RB Pathology R Medicine > RJ Pediatrics
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	02 May 2023 10:08
URI:	http://gala.gre.ac.uk/id/eprint/35554

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