Osman, Muhammad ORCID: 0000-0003-3818-9729, Harausz, Elizabeth P., Garcia-Prats, Anthony J., Schaaf, H. Simon, Moore, Brittany K., Hicks, Robert M., Achar, Jay, Amanullah, Farhana, Barry, Pennan, Becerra, Mercedes, Chiotan, Domnica I., Drobac, Peter C., Flood, Jennifer, Furin, Jennifer, Gegia, Medea, Isaakidis, Petros, Mariandyshev, Andrei, Ozere, Iveta, Shah, N. Sarita, Skrahina, Alena, Yablokova, Elena, Seddon, James A. and Hesseling, Anneke C. (2019) Treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis. Emerging Infectious Diseases, 25 (3). pp. 441-450. ISSN 1080-6040 (Print), 1080-6059 (Online) (doi:https://doi.org/10.3201/eid2503.180852)

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Abstract

Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required.

Item Type:	Article
Uncontrolled Keywords:	paediatric tuberculosis; drug-resistant tuberculosis; tuberculosis outcomes
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > RJ Pediatrics
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	22 Mar 2022 18:06
URI:	http://gala.gre.ac.uk/id/eprint/35553

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