Eliasy, Ashkan, Chen, Kai-Jung, Vinciguerra, Riccardo, Maklad, Osama ORCID: 0000-0001-6893-2654, Vinciguerra, Paolo, Ambrósio, Renato Jr., Roberts, Cynthia J. and Elsheikh, Ahmed (2018) Ex-vivo experimental validation of biomechanically-corrected intraocular pressure measurements on human eyes using the CorVis ST. Experimental eye research, 175. pp. 98-102. ISSN 0014-4835 (doi:https://doi.org/10.1016/j.exer.2018.06.013)

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Abstract

The purpose of this study was to assess the validity of the Corvis ST (Oculus; Wetzlar, Germany) biomechanical correction algorithm (bIOP) in determining intraocular pressure (IOP) using experiments on ex-vivo human eyes. Five ex-vivo human ocular globes (age 69 ± 3 years) were obtained and tested within 3–5 days post mortem. Using a custom-built inflation rig, the internal pressure of the eyes was controlled mechanically and measured using the CorVis ST (CVS-IOP). The CVS-IOP measurements were then corrected to produce bIOP, which was developed for being less affected by variations in corneal biomechanical parameters, including tissue thickness and material properties. True IOP (IOPt) was defined as the pressure inside of the globe as monitored using a fixed pressure transducer. Statistical analyses were performed to assess the accuracy of both CVS-IOP and bIOP, and their correlation with corneal thickness. While no significant differences were found between bIOP and IOPt (0.3 ± 1.6 mmHg, P = 0.989) using ANOVA and Bonferroni Post-Hoc test, the differences between CVS-IOP and IOPt were significant (7.5 ± 3.2 mmHg, P < 0.001). Similarly, bIOP exhibited no significant correlation with central corneal thickness (p = 0.756), whereas CVS-IOP was significantly correlated with the thickness (p < 0.001). The bIOP correction has been successful in providing close estimates of true IOP in ex-vivo tests conducted on human donor eye globes, and in reducing association with the cornea's thickness.

Item Type:	Article
Uncontrolled Keywords:	intraocular pressure; tonometry; corneal biomechanics
Subjects:	R Medicine > RE Ophthalmology T Technology > TJ Mechanical engineering and machinery
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Last Modified:	16 May 2022 12:45
URI:	http://gala.gre.ac.uk/id/eprint/35515

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