Selmi-Higashi, Elias, Zhang, Jinlei, Cambeiro, Xacobe C. ORCID: https://orcid.org/0000-0002-7365-7201 and Arseniyadis, Stellios ORCID: https://orcid.org/0000-0001-6831-2631 (2021) Synthesis of α-Difluoromethyl aryl ketones through a photoredox difluoromethylation of enol silanes. Organic Letters, 23 (11). pp. 4239-4243. ISSN 1523-7060 (Print), 1523-7052 (Online) (doi:10.1021/acs.orglett.1c01177)

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Abstract

We report here an efficient and highly straightforward access to α-difluoromethylated ketones through a visible light-mediated difluoromethylation of readily available enol silanes. The method, which takes advantage of the polyvalence of Hu’s reagent, N-tosyl-S-difluoromethyl-S-phenylsulfoximine, used here as a CHF2 radical precursor under catalytic photoredox conditions, is practical, scalable, and provides the corresponding α-CHF2 ketones in good to excellent yields.

Item Type:	Article
Uncontrolled Keywords:	Ethers, Transfer reactions, Catalysts, Aromatic compounds, Ketones
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	24 May 2022 01:38
URI:	http://gala.gre.ac.uk/id/eprint/33096

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