Everett, Jeremy ORCID: 0000-0003-1550-4482 (2019) Pharmacometabonomics: the prediction of drug effects using metabolic profiling. In: Barrett, James E., Page, Clive P. and Michel, Martin C., (eds.) Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology, 260 . Springer, Cham, Switzerland, pp. 263-300. ISBN 978-3030353612 (doi:https://doi.org/10.1007/164_2019_316)

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PDF (Author's Accepted Chapter) 26955 EVERETT_Pharmacometabonomics_Prediction_Of_Drug_Effects_Using_Metabolic_Profiling_(AAM)_2019.pdf - Accepted Version Download (2MB) | Preview

Abstract

Metabonomics, also known as metabolomics, is concerned with the study of metabolite profiles in humans, animals, plants and other systems in order to assess their health or other status and their responses to experimental interventions. Metabonomics is thus widely used in disease diagnosis and in understanding responses to therapies such as drug administration. Pharmacometabonomics, also known as pharmacometabolomics, is a related methodology but with a prognostic as opposed to diagnostic thrust. Pharmacometabonomics aims to predict drug effects including efficacy, safety, metabolism and pharmacokinetics, prior to drug administration, via an analysis of pre-dose metabolite profiles. This article will review the development of pharmacometabonomics as a new field of science that has much promise in helping to deliver more effective personalised medicine, a major goal of 21st century healthcare.

Item Type:	Book Section
Uncontrolled Keywords:	pharmacometabonomics, pharmacometabolomics, precision medicine, personalised medicine, metabonomics, metabolomics, metabotypes, metabolic phenotyping, systems medicine, NMR spectroscopy
Subjects:	R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	11 Dec 2021 01:38
URI:	http://gala.gre.ac.uk/id/eprint/26955

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