Angulo Pinzon, O.A., Berry, R.J., Bradley, M.S., Farnish, R.J. and Antonijevic, M.D. ORCID: 0000-0002-5847-7886 (2009) The impact of powder flowing properties on dosator filling system operation. In: 2009 AAPS Annual Meeting and Exposition, 8-12 Nov 2009, Los Angeles, USA.

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Abstract

Purpose: To study the impact of powder flow properties on dosator filling systems, with particular focus on improvements in dose weight accuracy and repeatability.

Method: This study evaluates a range of critical powder flow properties such as: flow function, cohesion, wall friction, adhesion to wall surfaces, density/compressibility data, stress ratio “K” and gas permeability. The characterisations of the powders considered in this study were undertaken using an annular shear cell using a sample size of 0.5 litres. This tester also incorporated the facility to measure bed expansion during shear in addition to contraction under consolidation forces. A modified Jenike type linear wall friction tester was used to develop the failure loci for the powder sample in conjunction with multiple wall samples (representing a variety of material types and surface finishes). Measurements of the ratio of applied normal stress versus lateral stress were determined using a piece of test equipment specifically designed for the purpose.

Results: The correct characterisation of powders and the incorporation of this data into the design of process equipment are recognised as critical for reliable and accurate operation. An example of one aspect of this work is the stress ratio “K”. This characteristic is not well understood or correctly interpreted in many cases – despite its importance. Fig 1 [Omitted] (illustrates a sample of test data. The slope of the line gives the stress ratio in a uniaxial compaction system – indicating the behaviour of the material under compaction during dosing processes.

Conclusions: A correct assessment of the bulk powder properties for a given formulation can allow prediction of: cavity filling behaviour (and hence dosage), efficiency of release from dosator, and strength and stability of extruded dose en route to capsule filling Influences over the effectiveness of dosator systems have been shown to be impacted upon by: bed pre-compaction history, gas permeability in the bed (with respect to local density effects), and friction effects for materials of construction for dosators

Item Type:	Conference or Conference Paper (Poster)
Additional Information:	[1] This item was a poster presentation at the 2009 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition held from 8-12 November 2009 in Los Angeles, USA. [2] The abstract for the poster presentation is located at: http://abstracts.aaps.org/published/ContentInfo.aspx?conID=18646 [3] AAPS Poster Number: W5392.
Uncontrolled Keywords:	dosator, powder flow
Subjects:	T Technology > TP Chemical technology R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI) Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Related URLs:	Publisher Publisher Publisher Organisation Organisation
Last Modified:	07 Feb 2020 15:53
URI:	http://gala.gre.ac.uk/id/eprint/2090

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