2023

Leach, Michael, and Williams, Paul, University of Greenwich (2023) Diazine and triazine compounds to treat cytokine storm syndrome US 2023/0165869 A1. US2023/0165869A1.

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as Interleukin Inhibitors (JP2023522436A). .

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as inhibitors of cytokine storm and cytokine storm syndrome (JP2023522444A). .

2022

Zhou, Jiabao, Down, Jennifer M, George, Christopher N, Murphy, Jessica, Lefley, Diane V, Tulotta, Claudia, Alsharif, Marwa A, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325 and Ottewell, Penelope D (2022) Novel methods of targeting IL-1 signalling for the treatment of breast cancer bone metastasis. Cancers, 14 (19):4816. ISSN 2072-6694 (Online) (doi:10.3390/cancers14194816)

2021

Leach, Michael, and Williams, Paul, University of Greenwich (2021) Diazine and triazine compounds to treat cytokine storm syndrome. WO2016198878A1.

University of Greenwich (2021) Interleukin Inhibitors. WO2021/214494 A1.

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

2018

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. US2018169105.

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. EP 3307273 (A1).

2017

University of Greenwich (2017) HK1170726 (A1)2017-06-02 Cyclic triazo sodium channel blockers. HK1179726 (A1).

2016

University of Greenwich (2016) Triazine derivatives as interferon gamma inhibitors. WO 2016/109978 A1.

University of Greenwich (2016) Cyclic triazo and diazo sodium channel blockers US divisional. US2016/0311784A1.

2015

University of Greenwich (2015) Medical uses of triazines. .

University of Greenwich, UK (2015) US9000155: Cyclic triazo sodium channel blockers. .

University of Greenwich, UK (2015) AU2014280981: Cyclic Triazo and Diazo channel blockers. .

2014

University of Greenwich, London UK (2014) HK1129206 (A1): New medical use of triazine derivatives. .

Michael Leach (2014) US2014243343 (A1)Cyclic triazo sodium channel blockers. .

University of Greenwich, London, UK (2014) US2014155403 Cyclic triazo and diazo sodium channel blockers. .

University of Greenwich, London UK (2014) ES24629727 (T3): New medical use of triazines. .

2012

University of Greenwich, UK (2012) KR20120048593 Cyclic triazo sodium channel blockers. KR20120048593 (A).

2011

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. JP2011144195.

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. EP2324828 (A1).

2010

University of Greenwich (2010) Cyclic triazo sodium channel blockers. 12801937.

BTG International Limited (2010) Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids. PT1853254 (E).

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

Xiang, M., Pinto, E., Rahman, M.A., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2010) Decreased monocyte chemoattractant protein 1 and relationship with 15-deoxy-delta 12,14- prostaglandin J2 in gamma-linolenic acid supplemented healthy subjects. Proceedings of the Nutrition Society, 69 (OCE3). E325-E325. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S002966511000114X)

BTG International Ltd (2010) Treatment of neurodegenerative conditions. US2010/0113810 A1.

2009

University of Greenwich, Old Royal Naval College Park Row, Greenwich London SE10 9LS (2009) Cyclic triazo and diazo sodium channel blockers. WO/2009/090431.

BTG International Ltd (2009) Structured phospholipids. US2009/0036410 A1.

2008

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

BTG International Limited (2008) Treatment of neurodegenerative conditions. GB2442161/B.

Xiang, M., Pinto, E., Rahman, M.A., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2008) Borage (Borago officinalis) oil supplementation in relation to monocyte chemoattractant protein 1 expression in healthy subjects. Proceedings of the Nutrition Society, 67 (OCE1). E44-E44. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006538)

Harbige, L.S., Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Sharief, M. K. (2008) PUFA in the pathogenesis and treatment of patients with multiple sclerosis. Proceedings of the Nutrition Society, 67 (OCE1). E21. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006307)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

University of Greenwich, Old Royal Naval College Park Row, Greenwich, London SE10 9LS (2008) New medical use of triazine derivatives. WO/2008/007149.

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

2007

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

2006

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. PCT/GB2006/000778.

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. WO2006/092622A1.

Harbige, L. S., Hollifield, R. D., Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Sharief, M. K. (2006) Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 July 2006, Cairns Convention Centre, Cairns, Queensland, Australia. (Unpublished)

Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2006) Effects of ω-6 fatty acid supplementation on chemokine production by peripheral blood mononuclear cells from healthy volunteers. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 Jul 2006, Cairns, Queensland, Australia. (Unpublished)

BTG International Limited (2006) Structured phospholipids. WO2006/056783 A2.

Riddall, Dieter R., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325 and Garthwaite, John (2006) A novel drug binding site on voltage-gated sodium channels in rat brain. Molecular Pharmacology, 69 (1). pp. 278-287. ISSN 1521-0111 (Online) (doi:10.1124/mol.105.015966)

2005

BTG International Limited (2005) Treatment of neurodegenerative conditions. WO2005/018632/A1.

2004

BTG International Limited (2004) Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease. WO2004/100943 A1.

BTG International Limited (2004) Treatment of neurodegenerative conditions. US 2004/0229873 Al.