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HK1170726 (A1)2017-06-02 Cyclic triazo sodium channel blockers

HK1170726 (A1)2017-06-02 Cyclic triazo sodium channel blockers

University of Greenwich (2017) HK1170726 (A1)2017-06-02 Cyclic triazo sodium channel blockers. HK1179726 (A1).

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A compound of formula ():wherein z is a single bond or an optionally substituted linking group; R1 is a halo-alkyl group; and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system; or a salt thereof. Preferred compounds include those where z is a single bond; A is selected from 2,3-dichlorophenyl, 2,3,5-trichlorophenyl, 3,5-bis(trifluoromethyl)phenyl, 3,4,5-trichlorothienyl and diphenylmethyl; R1 is selected from CH2CC13, CF2CF3, CH2CHC12and CH2CBr3. The compounds are useful as sodium channel blockers and as antimalarials.

Item Type: Patent
Additional Information: In Mandarin.
Uncontrolled Keywords: Cyclic Triazo Sodium channel blockers
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified: 09 Oct 2021 04:45

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