Kokrasvili, Anna, Harizopoulou, Vikentia, Bolou, Angeliki ORCID: https://orcid.org/0000-0002-8606-2805 and Gourounti, Kleanthi (2024) Pathophysiology of preeclampsia. Pharmakon Press, 41 (3):1. pp. 135-140. ISSN 1011-6575 (Print), 2945-1914 (Online) (doi:10.61873/CQZB7130)

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Abstract

Preeclampsia is a hypertensive disease that occurs during pregnancy in 3 to 8% of pregnancies worldwide. This disease causes significant maternal and perinatal morbidity and mortality. This article attempts to understand the pathophysiological mechanism of preeclampsia, which appears to result from a complex interaction between maternal and fetal factors and affects multiple organ systems. A central role in pre-eclampsia appears to be abnormal placentation with subsequent excess of anti-angiogenic factors and malabsorption. Further studies are needed to elucidate the pathophysiology of preeclampsia to better understand the disease, more appropriate treatment, and reduce maternal and neonatal morbidity and mortality.

Item Type:	Article
Uncontrolled Keywords:	preeclampsia; pathophysiological mechanism of preeclampsia; uteroplacental insufficiency; placental vasculopathy
Subjects:	R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing Faculty of Education, Health & Human Sciences > School of Health Sciences (HEA)
Last Modified:	14 Feb 2024 16:28
URI:	http://gala.gre.ac.uk/id/eprint/45879

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