Maniruzzaman, Mohammed, Morgan, David J., Mendham, Andrew P., Pang, Jiayun ORCID: https://orcid.org/0000-0003-0689-8440, Snowden, Martin J. ORCID: https://orcid.org/0000-0002-1087-2692 and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2012) Drug–polymer intermolecular interactions in hot-melt extruded solid dispersions. International Journal of Pharmaceutics, 443 (1-2). pp. 199-208. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.11.048)

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Abstract

The purpose of the study was to investigate and identify the interactions within solid dispersions of cationic drugs and anionic polymers processed by hot-melt extrusion (HME) technique. Propranolol HCl (PRP) and diphenhydramine HCl (DPD) were used as model cationic active substances while pH sensitive anionic methacrylic acid based methyl methacrylate copolymers Eudragit L100® (L100) and ethyl acrylate copolymer Eudragit L100-55 (Acryl EZE) (L100-55) were used as polymeric carriers. The extrudates were further characterised using various physicochemical characterisation techniques to determine the morphology, the drug state within the polymer matrices and the type of drug–polymer interactions. Molecular modelling predicted the existence of two possible H-bonding types while the X-ray photon spectroscopy (XPS) advanced surface analysis of the extrudates revealed intermolecular ionic interactions between the API amino functional groups and the polymer carboxylic groups through the formation of hydrogen bonding. The magnitude of the intermolecular interactions varied according to the drug–polymer miscibility.

Item Type:	Article
Additional Information:	[1] Available online 20 December 2012. [2] Published in International Journal of Pharmaceutics, Volume 443, Issues 1–2, 25 February 2013.
Uncontrolled Keywords:	solid dispersions, cationic drugs, anionic polymers, hot-melt extrusion (HME) technique
Subjects:	Q Science > QC Physics Q Science > QD Chemistry
Pre-2014 Departments:	School of Science
Related URLs:	Publisher
Last Modified:	21 Oct 2020 22:09
URI:	http://gala.gre.ac.uk/id/eprint/9983

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