Spencer, John (2010) Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:10.4155/fmc.09.114)

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Abstract

Microwave-mediated chemistry, involving the reduction of nitroarenes with molybdenum hexacarbonyl as a stoichiometric reducing agent, has been employed in the synthesis of a range of anilines. Many of these reactions exhibit high levels of chemoselectivity, tolerating unsaturation, steric hindrance and halide substituents (I, Br, Cl or F), although the latter, under certain circumstances, can be displaced in concomitant SNAr/reduction processes. The reduction chemistry has been combined with palladium-catalyzed coupling and also used in the synthesis of important intermediates to kinase inhibitors or molecules with submicromolar antitrypanosomal activity. In selected cases, microwave-mediated routes have been compared with thermal (traditional oil bath) and flow reactor-mediated chemistries.

Item Type:	Article
Additional Information:	[1] Future Medicinal Chemistry - Special Focus: Microwaves in Medicinal Chemistry - News & Analysis.
Uncontrolled Keywords:	microwave-mediated chemistry, stoichiometric reducing agent, anilines, chemoselectivity, steric hindrance, halide substituents (I, Br, Cl or F), SNAr/reduction processes, palladium-catalyzed coupling, submicromolar antitrypanosomal activity
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	17 Oct 2016 09:11
URI:	http://gala.gre.ac.uk/id/eprint/7762

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