Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

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Abstract

A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.

Item Type:	Article
Uncontrolled Keywords:	microwave-assisted synthesis, oxazoles, parallel synthesis, flow chemistry
Subjects:	Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	06 Dec 2016 16:07
URI:	http://gala.gre.ac.uk/id/eprint/7695

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