Brucoli, Federico, Hawkins, Rachel M., James, Colin H., Wells, Geoff, Jenkins, Terrence C., Ellis, Tom, Hartley, John A., Howard, Philip W. and Thurston, David E. (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters, 21. pp. 3780-3783. ISSN 0960-894X (online) (doi:https://doi.org/10.1016/j.bmcl.2011.04.054)

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Abstract

A series of novel DNA-interactive C8-linked pyrrolobenzodiazepine (PBD)–heterocycle polyamide conjugates has been synthesised to explore structure/sequence-selectivity relationships. One conjugate (2d) has a greater selectivity and DNA binding affinity for inverted CCAAT sequences within the Topoisomerase IIa promoter than the known C8-bis-pyrrole PBD conjugate GWL-78 (1b).

Item Type:	Article
Uncontrolled Keywords:	pyrrolobenzodiazepine (PBD)-conjugate, inverted CCAAT box, nuclear factor Y, topoisomerase IIa, nticancer agents
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	07 Dec 2016 10:12
URI:	http://gala.gre.ac.uk/id/eprint/7503

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