Liu, Lu, Huang, Xiaochen, Xu, Jingjing, Wang, Xixiang, Liu, Yu ORCID: https://orcid.org/0000-0001-5214-2973, Ren, Xiuwen, Zhang, Chi, Wang, Ying, Wang, Yueyong, Zhou, Shaobo ORCID: https://orcid.org/0000-0001-5214-2973 and Yuan, Linhong (2025) Impact of fish oil supplement on brain lipids profile in ApoE-/- mice and C57BL/6J mice treated with diets containing different dosage of vitamin E. The Journal of Nutritional Biochemistry (JNB):109964. ISSN 0955-2863 (Print), 1873-4847 (Online) (doi:10.1016/j.jnutbio.2025.109964)

PDF (Author's Accepted Manuscript) 50621 ZHOU_Impact_Of_Fish_Oil_Supplement_On_Brain_Lipids_Profile_In_ApoE-_-_Mice_And_C57BL_6J_Mice_(AAM)_2025.pdf - Accepted Version Restricted to Repository staff only until 22 May 2026. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (936kB) | Request a copy

Abstract

The study was designed to explore the impact of fish oil supplement on the brain lipids profile in ApoE-deficient (ApoE^-/-) mice and wild-type C57BL/6J (C57 wt) mice treated with diets containing varying dosage of vitamin E (VE). Compared to C57 wt mice, ApoE^-/- mice exhibited increased cortical TC and LDL-C levels, but decreased HDL-C level (P < 0.05). The fish oil intervention, combined with low dietary VE intake, resulted in increased cortical protein expression of CD36 and PPARγ in C57 wt mice. PI (36:5) was identified as a significantly different metabolite when compared to the control group in both C57 wt and ApoE^-/- mice. The combination of fish oil and varying doses of VE had different effects on the expression of brain lipids and fatty acid transporters in ApoE^-/- and C57 wt mice, indicating that ApoE status and dietary VE intake influence the responses of the cerebral lipids profile to fish oil supplementation.

Item Type:	Article
Uncontrolled Keywords:	ApoE-/-, fish oil, dosage of VE, lipid metabolism
Subjects:	Q Science > Q Science (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	02 Jun 2025 09:45
URI:	http://gala.gre.ac.uk/id/eprint/50621

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