Li, Pengfei, Xu, Jingjing, Guo, Yujie, Ma, Xiaojun, Wang, Xixiang, Liu, Lu, Yu, Liu, Ren, Xiuwen, Li, Jiahao, Wang, Ying, Meng, Liping, Zhou, Shaobo ORCID: https://orcid.org/0000-0001-5214-2973 and Yuan, Linhong (2025) Impact of vitamin A on aged people’s cognition and Alzheimer’s disease progression in an animal model. npj Science of Food, 9 (67). pp. 1-15. ISSN 2396-8370 (Online) (doi:10.1038/s41538-025-00402-1)

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Abstract

The relation between vitamin A (VA) level and cognitive function and the underlying mechanisms havenot been thoroughly investigated. Population-based cross-sectional and animal diet interventionstudies were conducted to analyze the association between VA nutritional status and cognitivefunction and the underlying mechanisms. In the population-based study, information from 1817 adultsaged 50 years and above was used for data analysis, and we found that subjects with plasma VA levelgreater than 0.539 μg/ml displayed a lower risk of mild cognitive impairment (MCI). In the animalexperiment, VA metabolism was disrupted in Alzheimer’s disease (AD) model mice, indicated byincreased hepatic VA level and reduced retinol binding protein 4 (RBP4) level. AD model mice fed withlow-VA diet showed worse nesting behavior, and cerebral pathologies, including increased Aβgeneration, exacerbated neuroinflammation, and impaired brain glucose uptake and insulin signalingpathway. In conclusion, higher plasma VA level (≥ 0.539 μg/ml) might decrease the risk of MCI in themiddle-aged and elderly individuals. Low VA nutritional status might disrupt brain glucose metabolismthrough regulating the insulin signaling pathway, promoting the senile plaque deposit and aggregatingcerebral neuroinflammation, finally exacerbating the pathology of AD.

Item Type:	Article
Uncontrolled Keywords:	vitamin A, cognition, Alzheimer’s disease, aged people, animal model
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	https://www.nature.com/articles/s41538-0...
Last Modified:	09 May 2025 07:52
URI:	http://gala.gre.ac.uk/id/eprint/50351

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