Flam-Ross, Juliet Miko and Zampini, Giulia Federica ORCID: https://orcid.org/0000-0002-9456-4792 (2025) Reported patient experiences of extended-release buprenorphine for opioid dependence: a qualitative systematic review and thematic analysis. Drugs: Education, Prevention, and Policy. ISSN 0968-7637 (Print), 1465-3370 (Online) (doi:10.1080/09687637.2025.2487446)

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Abstract

Background and Aims
There is a growing opioid overdose crisis internationally. One evidence-based solution is a newly available form of opioid substitution treatment: extended-release buprenorphine (XR-BUP). The following study aims to systematically review the qualitative evidence of reported patient experiences of XR-BUP.

Methods
We conducted a systematic review to synthesize qualitative literature on patient experiences of XR-BUP. In June 2023, we searched five databases. Articles were screened using clearly defined inclusion and exclusion criteria. Critical appraisal and thematic analysis using stigma as an organizing concept were carried out.

Results
We screened 581 titles and abstracts and selected 13 articles. We identified six key themes: 1) living a normal life 2) Being perceived as a “drug user”; 3) physiological effects of the drug; 4) investments (time and money); 5) life goals; and 6) the luxury of time.

Conclusions
Our review elevates XR-BUP as a powerful technology for the reduction of stigma. However, patient agency and autonomy should be at the forefront of decision-making around treatment options. Providers of treatment for opioid dependence can use this study alongside local context to consider the introduction or expansion of treatment with XR-BUP.

Item Type:	Article
Uncontrolled Keywords:	XR BUP, extended release buprenorphine, patient experiences
Subjects:	H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Liberal Arts & Sciences Faculty of Liberal Arts & Sciences > School of Law & Criminology (LAC)
Last Modified:	23 Apr 2025 11:33
URI:	http://gala.gre.ac.uk/id/eprint/50235

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