Salehzadeh, Hamid, Bigdelia, Zahra Rostami and Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212 (2025) Electrochemically assisted Friedlander reaction: a highly efficient and sustainable method for quinoline synthesis. Green Chemistry. ISSN 1463-9262 (Print), 1463-9270 (Online) (doi:10.1039/D5GC00330J)

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Abstract

The Friedländer reaction is a well-established method for quinoline synthesis. However, it has significant limitations, including long reaction times, the use of environmentally harmful solvents and reagents, and significant waste generation. In this study, we present a simple, sustainable, efficient and one-step electrosynthetic strategy for the synthesis of quinolines from readily available nitro compounds using electric current. This reagent-free method operates under mild conditions with a constant-current electrolysis setup and achieves high conversion rates with excellent atom economy. Various substituted quinolines were successfully synthesised in good to excellent yields. In addition, cyclic voltammetry and controlled potential electrolysis studies were carried out to investigate the reaction mechanism of quinoline formation.

Item Type:	Article
Additional Information:	Confirmation Received from author via email communication that "This is also the accepted manuscript (the one we sent to the editor and which got accepted before any proofs were sent back to us for corrections)." - MP
Uncontrolled Keywords:	quinoline, electrosynthesis, reduction, nitro
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry T Technology > TP Chemical technology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	13 Mar 2025 13:55
URI:	http://gala.gre.ac.uk/id/eprint/49979

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