Kibugu, James ORCID: https://orcid.org/0000-0002-5764-5083, Munga, Leonard ORCID: https://orcid.org/0000-0003-2724-4868, Mburu, David ORCID: https://orcid.org/0000-0002-0102-6291, Maloba, Fredrick, Auma, Joanna E. ORCID: https://orcid.org/0000-0002-0717-5554, Grace, Delia ORCID: https://orcid.org/0000-0002-0195-9489 and Lindahl, Johanna F. ORCID: https://orcid.org/0000-0002-1175-0398 (2024) Dietary mycotoxins: an overview on toxicokinetics, toxicodynamics, toxicity, epidemiology, detection, and their mitigation with special emphasis on aflatoxicosis in humans and animals. Toxins, 16 (11):483. ISSN 2072-6651 (Online) (doi:10.3390/toxins16110483)

Preview

PDF (Open Access Article) 49607 GRACE_Dietary_Mycotoxins_An_Overview_On_Toxicokinetics_Toxicodynamics_Toxicity_Epidemiology_Detection_And_Their_Mitigation_(OA)_2024.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Mycotoxins are secondary metabolites of filamentous fungi and ubiquitous dietary contaminants. Aflatoxins, a group of mycotoxins with high prevalence and toxicity, have raised a high level of public health concern, the most prevalent and toxic being aflatoxin B1 (AFB1). Many aspects appertaining to AFB1 poisoning are not well understood. Yet this information is necessary to devise appropriate surveillance and mitigation strategies against human and animal aflatoxicosis. This review provides an in-depth update of work carried out on mycotoxin poisoning, particularly aflatoxicosis in humans and animals, to identify gaps in knowledge. Hypotheses explaining the functional significance of mycotoxins in fungal biology and their dietary epidemiological data are presented and briefly discussed. The toxicology of aflatoxins and the challenges of their mitigation are discussed in depth. It was concluded that the identification of potential mycotoxin-hazard-prone food items and quantification of the associated risk of cancer ailments in humans is a prime priority. There is a dearth of reliable sampling methodologies for estimating AFB1 in animal feed. Data update on AFB1 in animal feed and its implication in animal production, mitigation strategies, and elucidation of risk factors to this hazard is required. To reduce the burden of aflatoxins, surveillance employing predictive technology, and biocontrol strategies seem promising approaches.

Item Type:	Article
Additional Information:	This article belongs to the Special Issue Occurrence, Toxicity, Metabolism, Analysis and Control of Mycotoxins.
Uncontrolled Keywords:	mycotoxins, epidemiology, aflatoxin, toxicology, toxicity, detection, control strategies
Subjects:	Q Science > Q Science (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine S Agriculture > S Agriculture (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Centre for Food Systems Research Faculty of Engineering & Science > Natural Resources Institute > Centre for Food Systems Research > Food Safety and Quality
Last Modified:	31 Jan 2025 12:04
URI:	http://gala.gre.ac.uk/id/eprint/49607

Actions (login required)

View Item

Downloads