Pinilla, Marta Suárez, Stoner, Charlotte R. ORCID: https://orcid.org/0000-0002-1536-4347, Knapp, Martin, Nachev, Parashkev and Rossor, Martin ORCID: https://orcid.org/0000-0001-8215-3120 (2025) The cognitive footprint of medication use. Brain and Behavior, 15 (1):e70200. ISSN 2162-3279 (Print), 2157-9032 (Online) (doi:10.1002/brb3.70200)

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Abstract

Introduction: The cognitive side‐effects of medication are common, but often overlooked in practice, and not routinely considered in interventional trials or post‐market surveillance. The cognitive footprint of a medication seeks to quantify the impact of its cognitive effects based on magnitude, duration, and interaction with other factors, evaluated across the exposed population.
Methods: Bayesian multivariable regression analysis of retrospective population‐based cross‐sectional cohorts.
Results: We replicate positive and negative cognitive effects of commonly used medications in UK Biobank, and extend observed associations to two additional cohorts, the EPIC Norfolk, and the Caerphilly Prospective Cohort. We quantify the resultant cumulative impact at the population level given known patterns of prescribing and compare it with exemplar common diseases.
Conclusion: The cognitive side‐effects of commonly used drugs may have significant impact at the population level. Consideration should be given to a routine structured assessment of cognition in interventional trials and post‐market surveillance.

Item Type:	Article
Uncontrolled Keywords:	medications; cognitive footprint; large-scale cohorts; medication side effects; cognition
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	22 Jan 2025 12:34
URI:	http://gala.gre.ac.uk/id/eprint/49510

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