Brightwell, Dominic F. ORCID: https://orcid.org/0000-0001-7699-9795, Samanta, Kushal ORCID: https://orcid.org/0000-0002-7414-4475, Muldoon, Jimmy ORCID: https://orcid.org/0000-0002-2187-9478, Fleming, Patricia C. ORCID: https://orcid.org/0009-0004-4449-0109, Ortin, Yannick ORCID: https://orcid.org/0000-0001-7685-2558, Mardiana, Lina ORCID: https://orcid.org/0000-0002-6639-4634, Waddell, Paul G. ORCID: https://orcid.org/0000-0002-7851-7347, Hall, Michael J. ORCID: https://orcid.org/0000-0001-6475-9161, Clark, Ewan R. ORCID: https://orcid.org/0000-0001-7287-2631, Fantuzzi, Felipe ORCID: https://orcid.org/0000-0002-8200-8262 and Palma, Aniello ORCID: https://orcid.org/0000-0001-9626-4390 (2024) Applying metallo‐organic ligand design principles to the stereoselective synthesis of a peptide‐based Pd2L4X4 cage. ChemistryEurope:e202400050. ISSN 2751-4765 (Online) (doi:10.1002/ceur.202400050)

Preview

PDF (Open Access Article) 48686 CLARK_Applying_Metallo‐Organic_Ligand_Design_Principles_To_The_Stereoselective_Synthesis_Of_A_Peptide‐Based_Pd2L4X4_Cage_(OA)_2024.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

The rational and controlled synthesis of metallo-organic cages using polyaromatic ligands is well established in the literature. There is a strong interest to advance this field towards the use of chiral ligands capable of yielding cages in a stereoselective manner. Herein, we demonstrate that the classical approach for designing metallo-organic cages can be translated to polyproline peptides, a biocompatible class of chiral ligands. We have successfully designed a series of polyprolines, which mimic the topology of ditopic polyaromatic ligands, to achieve the stereoselective synthesis of a novel Pd lantern cage. This cage exhibits excellent stability in water and demonstrates the stabilization of a highly reactive species in solution. This work will pave the way towards the stereospecific synthesis of more complex, functionalized peptide-based metallo-cages.

Item Type:	Article
Uncontrolled Keywords:	peptide-based metallo-cages, supramolecular chemistry, polyproline, peptide-based supramolecular chemistry, host-guest systems
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry T Technology > TP Chemical technology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	25 Nov 2024 14:41
URI:	http://gala.gre.ac.uk/id/eprint/48686

Actions (login required)

View Item

Downloads