Nie, Yinyue, Huang, Luyue ORCID: 0000-0001-5214-2973 , Wang, Luchuan, Zeng, Pei, Gong, Chao ORCID: 0000-0001-5214-2973 , Song, Lin, Guo, Jin and Zhou, Shaobo ORCID: 0000-0001-5214-2973 (2024) Vitamin D3 treatment reduced epileptic neuronal damage by inhibiting apoptosis and increasing vitamin D receptor expression in an in vivo epileptic model. Journal of Integrative Neuroscience. ISSN 0219-6352 (Print), 1757-448X (Online) (In Press)

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Abstract

Background: Vitamin D (VitD) deficiency is prevalent in more than half of patients treated with antiepileptic drugs. The number of seizures decreased by more than 40% after vitamin D3 supplementation. This study aimed to investigate the antiepileptic effects of vitamin D3 by using an in vivo epileptic model. Method: Sprague–Dawley rats received pentylenetetrazole (i.p.) treatment to induce epilepsy and then treated with sodium valproate, VitD or a combination of VitD and paricalcitol. Results: Vitamin D3 treatment improved epileptic behavior, as evidenced by increased latency time and a significant reduction in epileptic scores on the seventh day after pentylenetetrazole challenge. Improvements in cell morphology and reduced neuronal damage were observed as well as decreased apoptosis rates caused by epilepsy. Although no significant changes in the calcium-sensing receptor (CaSR) were observed among all groups, the level of VitD receptor (VDR) significantly increased in groups treated with vitamin D3 alone, w

Item Type:	Article
Uncontrolled Keywords:	epilepsy, vitamin D3, apoptosis, vitamin D receptor, rats
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	https://www.imrpress.com/journal/JIN/
Last Modified:	15 Nov 2024 12:24
URI:	http://gala.gre.ac.uk/id/eprint/48625

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